[1]孟灿,郭丽,潘艳萍,等.化疗前血清Flt3L和ACLY对急性髓系白血病预后的预测价值[J].陕西医学杂志,2025,54(6):814-818.[doi:DOI:10.3969/j.issn.1000-7377.2025.06.018]
　MENG Can,GUO Li,PAN Yanping,et al.Prognostic value of serum Flt3L and ACLY before chemotherapy in acute myeloid leukemia[J].,2025,54(6):814-818.[doi:DOI:10.3969/j.issn.1000-7377.2025.06.018]
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化疗前血清Flt3L和ACLY对急性髓系白血病预后的预测价值

《陕西医学杂志》[ISSN:1000-7377/CN:61-1281/TN]

卷:
54
期数:
2025年6期
页码:
814-818
栏目:
临床检验
出版日期:
2025-06-05

文章信息/Info

Title:
Prognostic value of serum Flt3L and ACLY before chemotherapy in acute myeloid leukemia
作者:
孟灿; 郭丽; 潘艳萍; 潘一洲; 符祥俊
（海南省人民医院血液内科，海南 海口 570311）
Author(s):
MENG Can; GUO Li; PAN Yanping; PAN Yizhou; FU Xiangjun
(Department of Hematology,Hainan General Hospital,Haikou 570311,China)
关键词:
急性髓系白血病; FMS样酪氨酸激酶3配体; ATP柠檬酸裂解酶; 危险分层; 相关性; 预后
Keywords:
Acute myeloid leukemia; Fms-like tyrosine kinase-3 ligand; ATP citrate lyase; Risk stratification; Correlation; Prognosis
分类号:
R 733.71
DOI:
DOI:10.3969/j.issn.1000-7377.2025.06.018
文献标志码:
A
摘要:
目的：探究化疗前血清FMS样酪氨酸激酶3配体（Flt3L）和ATP柠檬酸裂解酶（ACLY）对急性髓系白血病（AML）预后的预测价值。方法：选取初诊AML患者120例为研究组，另选同期同年龄段体检健康者60例为对照组。比较两组基一般资料及血清Flt3L、ACLY水平；比较研究组不同临床特征患者血清Flt3L、ACLY水平；分析血清Flt3L、ACLY水平与AML患者临床特征的相关性；比较研究组化疗后1年不同预后患者化疗前临床资料及血清Flt3L、ACLY水平；分析研究组预后影响因素及化疗前血清Flt3L、ACLY水平对患者病死的预测价值。结果：研究组血清Flt3L水平低于对照组，ACLY水平高于对照组（均P＜0.05）。AML患者血清Flt3L水平与危险分层、白细胞计数、脾肿大呈负相关，ACLY水平与危险分层、白细胞计数、脾肿大呈正相关，AML患者血清Flt3L水平与ACLY水平呈负相关（均P＜0.05）。年龄、危险分层、白细胞计数、脾肿大、血清ACLY均为AML患者化疗后1年病死的危险因素，血清Flt3L为保护因素（均P＜0.05）。化疗前血清Flt3L、ACLY预测病死的曲线下面积（AUC）分别为0.752、0.788，血清Flt3L、ACLY联合预测的AUC为0.923，联合预测的AUC高于单独预测的AUC（均P＜0.05）。结论：AML患者化疗前血清Flt3L联合ACLY可为临床预测预后转归提供可靠参考依据。
Abstract:
Objective:To explore the prognostic value of serum Fms-like tyrosine kinase-3 ligand (Flt3L) and ATP citrate lyase (ACLY) before chemotherapy in acute myeloid leukemia (AML).Methods：A total of 120 newly diagnosed AML patients were selected as the study group,and 60 age-matched healthy people healthy patients in the same period were selected as the control group.The basic data,serum Flt3L and ACLY levels of the two groups were compared.The serum Flt3L and ACLY levels of patients with different clinical characteristics of the study group were compared.The correlation between the serum Flt3L and ACLY levels and the clinical characteristics of AML patients was analyzed.The clinical data,serum Flt3L and ACLY levels of patients with different prognosis 1 year after chemotherapy were compared in the study group.The prognostic factors of the study group and the predictive value of serum Flt3L and ACLY levels before chemotherapy for the death of patients were analyzed.Results:The serum Flt3L level in the study group was lower than that in the control group,while the ACLY level was higher (all P<0.05).The serum Flt3L level in AML patients was negatively correlated with risk stratification,white blood cell count and splenomegaly,while ACLY level was positively correlated with risk stratification,white blood cell count and splenomegaly,and AML patients’ serum Flt3L level was negatively correlated with ACLY level (all P<0.05).Age,risk stratification,white blood cell count,splenomegaly and serum ACLY level were risk factors for death in AML patients 1 year after chemotherapy,while serum Flt3L level was protective factor (all P<0.05).The AUC of serum Flt3L and ACLY for predicting death before chemotherapy was 0.752 and 0.788,respectively.The AUC of serum Flt3L and ACLY combined prediction was 0.923.The AUC of combined prediction was higher than that of single prediction (both P<0.05).Conclusion:The combination of serum Flt3L and ACLY levels before chemotherapy in AML patients can provide a reliable reference basis for clinical prediction of prognostic regression.

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备注/Memo

备注/Memo:
海南省自然科学基金资助面上项目（820MS137）；海南省“南海新星”医疗卫生人才平台立项课题（NHXX-WJW-2023002）
更新日期/Last Update: 2025-06-04