[1]王立娟,刘志华,王东亚.CO2激光术联合复方斑蝥胶囊治疗早期声门型喉癌临床价值研究[J].陕西医学杂志,2025,54(5):674-677,682.[doi:DOI:10.3969/j.issn.1000-7377.2025.05.020]
　WANG Lijuan,LIU Zhihua,WANG Dongya.Value of CO2 laser surgery combined with compound cantharidin capsules in the treatment of early glottic laryngeal cancer[J].,2025,54(5):674-677,682.[doi:DOI:10.3969/j.issn.1000-7377.2025.05.020]
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CO2激光术联合复方斑蝥胶囊治疗早期声门型喉癌临床价值研究
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《陕西医学杂志》[ISSN:1000-7377/CN:61-1281/TN]

卷:
54
期数:
2025年5期
页码:
674-677,682
栏目:
药物与临床
出版日期:
2025-05-05

文章信息/Info

Title:
Value of CO2 laser surgery combined with compound cantharidin capsules in the treatment of early glottic laryngeal cancer
作者:
王立娟1; 刘志华1; 王东亚2
(1.保定市第二医院耳鼻咽喉科,河北 保定 073199; 2.保定市第二医院麻醉科,河北 保定 073199)
Author(s):
WANG Lijuan1; LIU Zhihua1; WANG Dongya2
(1.Department of Otolaryngology,the No.2 Hospital of Baoding,Baoding 073199,China; 2.Department of Anesthesiology,the No.2 Hospital of Baoding,Baoding 073199,China)
关键词:
早期声门型喉癌;  CO2激光术;  复方斑蝥胶囊;  嗓音功能;  免疫功能;  吞咽功能;  生活质量
Keywords:
Early glottic laryngeal cancer;  CO2 laser surgery;  Compound cantharidin capsules;  Voice function;  Immune function;  Swallowing function;  Quality of life
分类号:
R 739.65
DOI:
DOI:10.3969/j.issn.1000-7377.2025.05.020
文献标志码:
A
摘要:
目的:探究CO2激光术联合复方斑蝥胶囊治疗早期声门型喉癌的临床价值。方法:选取80例早期声门型喉癌患者,随机分为手术组(40例)和联合组(40例)。手术组给予CO2激光术联合含0.9%氯化钠溶液胶囊治疗,联合组给予CO2激光术联合复方斑蝥胶囊治疗。比较两组治疗前及治疗后1年嗓音功能、免疫功能、吞咽功能及生活质量。两组治疗后随访1年,记录患者复发情况。结果:治疗后1年,两组患者谐噪比高于治疗前,基频微扰、振幅微扰低于治疗前,且联合组谐噪比高于手术组,基频微扰、振幅微扰低于手术组(均P<0.05)。治疗后1年,手术组CD3+、CD4+、CD4+/CD8+水平低于治疗前,联合组CD3+、CD4+、CD4+/CD8+水平高于治疗前,且联合组高于手术组(均P<0.05)。治疗后1年,两组吞咽功能评估量表(GUSS)评分和功能、总体生命质量评分高于治疗前,症状评分低于治疗前,且联合组GUSS评分和功能、总体生命质量评分高于手术组,症状评分低于手术组(均P<0.05)。两组治疗后1年复发率比较差异无统计学意义(P>0.05)。结论:CO2激光术联合复方斑蝥胶囊治疗早期声门型喉癌能够促进嗓音功能恢复,改善免疫及吞咽功能,提高患者生活质量。
Abstract:
Objective:To explore the clinical value of CO2 laser surgery combined with compound cantharidin capsules in the treatment of early glottic laryngeal cancer.Methods:A total of 80 patients with early glottic laryngeal cancer were selected and randomly divided into an operation group(40 cases)and a combination group(40 cases).The operation group received CO2 laser surgery combined with capsules containing 0.9% sodium chloride solution,while the combination group received CO2 laser surgery combined with compound cantharidin capsules.Voice function,immune function,swallowing function and quality of life were compared between the two groups before and one year after treatment.Both groups were followed up for one year post-treatment,and recurrence rates were recorded.Results:One year after treatment,the harmonic-to-noise ratio was higher and the jitter and shimmer were lower in both groups compared to before treatment,and the combination group had a higher harmonic-to-noise ratio and lower jitter and shimmer than the operation group(all P<0.05).One year after treatment,the levels of CD3+,CD4+ and CD4+/CD8+ were lower in the operation group and higher in the combination group compared to before treatment,with the combination group showing higher levels than the operation group(all P<0.05).One year after treatment,the Gugging Swallowing Screen(GUSS)scores,functional and overall quality of life scores in both groups were higher than before treatment,while symptom scores were lower than before treatment.The combination group had higher GUSS scores,functional and overall quality of life scores,and lower symptom scores compared to the operation group(all P<0.05).There was no significant difference in the recurrence rate between the two groups one year after treatment(P>0.05).Conclusion:CO2 laser surgery combined with compound cantharidin capsules in the treatment of early glottic laryngeal cancer can promote the recovery of voice function,improve immune and swallowing functions,and enhance the quality of life of patients.

参考文献/References:

[1] MACNEIL S D.Non-squamous laryngeal cancers[J].Otolaryngol Clin North Am,2023,56(2):345-359.
[2] 单凤金,张义,许尧生.丝裂原活化蛋白激酶4、生存素基因在喉鳞状细胞癌组织中的表达及其意义[J].陕西医学杂志,2024,53(1):122-126.
[3] CETINAYAK O,DOGAN E,KURU A,et al.Outcome of early-stage glottic laryngeal carcinoma patients treated with radical radiotherapy using different techniques[J].J Oncol,2019,2019:8640549.
[4] LECHIEN J R,BAUDOUIN R,CIRCIU M P,et al.Transoral robotic cordectomy for glottic carcinoma:A rapid review[J].Eur Arch Otorhinolaryngol,2022,279(11):5449-5456.
[5] DE-RIDDER M,RIJKEN J A,SMITS H J G,et al.Oncological outcome of vocal cord-only radiotherapy for cT1-T2 glottic laryngeal squamous cell carcinoma[J].Eur Arch Otorhinolaryngol,2023,280(7):3345-3352.
[6] CABRERA-SARMIENTO J A,VÁZQUEZ-BARRO J C,GONZÁLEZ-BOTAS J H,et al.T1b glottic tumor and anterior commissure involvement:Is the transoral CO2 laser microsurgery a safe option?[J]Ear Nose Throat J,2021,100(1_suppl):68s-72s.
[7] VERRO B,GRECO G,CHIANETTA E,et al.Management of early glottic cancer treated by CO2 laser according to surgical-margin status:A systematic review of the literature[J].Int Arch Otorhinolaryngol,2021,25(2):e301-e308.
[8] SOLARZ P,MACKIEWICZ-NARTOWICZ H,SINKIEWICZ A,et al.Results of CO2 laser surgery in laryngeal papillomatosis[J].Oral Oncol,2024,158:107004.
[9] SONG Y,LIU X,FENG H.CO2 laser combined with low-temperature plasma radiofrequency ablation promotes recovery of swallowing function in elderly patients with early glottic carcinoma[J].Am J Transl Res,2023,15(8):5314-5322.
[10] 侯杰,时克,刘遥,等.复方斑蝥胶囊辅助治疗对原发性肝癌脾虚血瘀证患者三年生存情况影响的回顾性研究[J].中医杂志,2022,63(13):1249-1255.
[11] 汪洋.支撑喉镜下低温射频等离子手术对早期声门型喉癌患者术后并发症及发音功能的影响[J].吉林医学,2021,42(12):2997-3000.
[12] IMRAN M,AL-WASSIA R,ALKHAYYAT S S,et al.Assessment of quality of life(QoL)in breast cancer patients by using EORTC QLQ-C30 and BR-23 questionnaires:A tertiary care center survey in the western region of Saudi Arabia[J].PLoS One,2019,14(7):e0219093.
[13] LI Y,RUAN S,HONG Y,et al.Reconstruction of laryngeal function by thyroid cartilage fenestration and draw-out resection followed by internal fixation with titanium microplates for early glottic carcinoma:A novel and efficient surgical approach[J].Am J Transl Res,2024,16(6):2589-2598.
[14] ELICIN O,GIGER R.Comparison of current surgical and non-surgical treatment strategies for early and locally advanced stage glottic laryngeal cancer and their outcome[J].Cancers(Basel),2020,12(3):732-751.
[15] FERMI M,LO MANTO A,DI MASSA G,et al.Paraglottic space invasion in glottic laryngeal cancer:A clinical-pathological study[J].Laryngoscope,2023,133(5):1184-1190.
[16] ONO T,ITOH Y,ISHIHARA S,et al.Optimized radiotherapy treatment strategy for early glottic carcinoma[J].Nagoya J Med Sci,2023,85(2):241-254.
[17] YIN Y,CAI Q,ZHENG Y,et al.CO2 transoral laser microsurgery for early glottic carcinoma with anterior commissure involvement[J].Auris Nasus Larynx,2023,50(3):415-422.
[18] GANDHI S,BHATTA S,GANESUNI D,et al.High-speed videolaryngoscopy in early glottic carcinoma patients following transoral CO2 LASER cordectomy[J].Eur Arch Otorhinolaryngol,2021,278(4):1119-1127.
[19] DALLARI S,GIANNONI L,FILOSA A.Scanning super/ultrapulsed CO2 laser efficacy in laryngeal malignant lesions[J].Medicina(Kaunas),2022,58(2):200-214.
[20] CHIESA-ESTOMBA C M,SISTIAGA-SUAREZ J A,GONZÁLEZ-GARCÍA J A,et al.Intraoperative surgical complications in transoral laser CO2 microsurgery of the larynx:An observational,prospective,single-center study[J].Ear Nose Throat J,2021,100(5_suppl):456s-461s.
[21] 任淑惠,王山川.复方斑蝥胶囊联合旋转容积调强技术对头颈部放疗生存期及血清XRCC1、XRCC3mRNA水平的影响[J].中华中医药学刊,2024,42(10):40-43.
[22] 张栓宝,严宁娟,张燕平.复方斑蝥胶囊对非小细胞肺癌患者围术期血清炎症因子及免疫功能的影响[J].陕西中医,2019,40(7):890-892.
[23] 洪桂花,陈思环,黄珊.复方斑蝥胶囊对原发性肝癌患者免疫功能及临床疗效的影响[J].世界中西医结合杂志,2020,15(2):365-368,373.
[24] 郭会娟,李彦丽,王建伟.复方斑蝥胶囊联合化疗治疗三阴性乳腺癌患者的疗效及对免疫功能的影响[J].癌症进展,2024,22(2):146-149.
[25] 吴崇山,陈再平,吴贵阳,等.复方斑蝥胶囊联合化疗治疗结直肠癌患者近期疗效及对生存质量、免疫功能和肿瘤标志物的影响[J].中国老年学杂志,2020,40(2):307-310.

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备注/Memo

备注/Memo:
[基金项目]河北省医学科学研究课题(20242031)
更新日期/Last Update: 2025-05-05