[1]褚 楚,王秀林,倪丹丹,等.米诺环素联合含青刺果油和酸浆提取物的屏障特护霜治疗玫瑰痤疮临床价值研究[J].陕西医学杂志,2025,54(5):665-668.[doi:DOI:10.3969/j.issn.1000-7377.2025.05.018]
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米诺环素联合含青刺果油和酸浆提取物的屏障特护霜治疗玫瑰痤疮临床价值研究
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《陕西医学杂志》[ISSN:1000-7377/CN:61-1281/TN]

卷:
54
期数:
2025年5期
页码:
665-668
栏目:
药物与临床
出版日期:
2025-05-05

文章信息/Info

作者:
褚 楚; 王秀林; 倪丹丹; 储丹凤
(海军军医大学第一附属医院皮肤性病科,上海 200433)
关键词:
玫瑰痤疮;  米诺环素;  青刺果油;  酸浆提取物;  屏障特护霜;  皮肤屏障功能;  炎症反应
分类号:
R 758.73
DOI:
DOI:10.3969/j.issn.1000-7377.2025.05.018
文献标志码:
A
摘要:
目的:探讨米诺环素联合含青刺果油和酸浆提取物的屏障特护霜治疗玫瑰痤疮的临床价值。方法:选取76例玫瑰痤疮患者,随机分为观察组(38例)和对照组(38例)。对照组给予米诺环素治疗,观察组在对照组基础上加用含青刺果油和酸浆提取物的屏障特护霜进行涂抹治疗。比较两组患者治疗后临床疗效,治疗前后皮肤屏障功能指标及血清炎症因子水平。观察治疗期间两组不良反应发生情况。治疗后随访3个月,观察玫瑰痤疮复发情况。结果:观察组临床总有效率高于对照组(P<0.05)。治疗后,两组表皮皮脂含量、角质层水含量、血清干扰素-γ(INF-γ)水平高于治疗前,且观察组高于对照组; 两组经皮失水量、pH值、皮肤红斑指数、血清肿瘤坏死因子-α(TNF-α)、白细胞介素-4(IL-4)水平低于治疗前,且观察组低于对照组(均P<0.05)。观察组治疗期间出现1例水肿瘙痒,但症状轻微,对照组未发生不良反应。两组玫瑰痤疮均未出现复发。结论:米诺环素联合含青刺果油和酸浆提取物的屏障特护霜治疗玫瑰痤疮具有较好的临床疗效,可改善患者皮肤屏障功能,减轻皮肤炎症反应。

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备注/Memo

备注/Memo:
[基金项目]上海市卫生健康委员会医学科学研究计划项目(2023SHW1069)
更新日期/Last Update: 2025-05-05