[1]庄 薇,姚荣华,周俊平.血清FGF21、LCN2和凝血功能与妊娠期亚临床甲状腺功能减退症患者妊娠结局关系研究[J].陕西医学杂志,2025,54(5):635-639.[doi:DOI:10.3969/j.issn.1000-7377.2025.05.012]
　ZHUANG Wei,YAO Ronghua,ZHOU Junping.Relationship between serum FGF21, LCN2, coagulation function and pregnancy outcomes in patients with subclinical hypothyroidism during pregnancy[J].,2025,54(5):635-639.[doi:DOI:10.3969/j.issn.1000-7377.2025.05.012]
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血清FGF21、LCN2和凝血功能与妊娠期亚临床甲状腺功能减退症患者妊娠结局关系研究
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《陕西医学杂志》[ISSN:1000-7377/CN:61-1281/TN]

卷:
54
期数:
2025年5期
页码:
635-639
栏目:
临床研究
出版日期:
2025-05-05

文章信息/Info

Title:
Relationship between serum FGF21, LCN2, coagulation function and pregnancy outcomes in patients with subclinical hypothyroidism during pregnancy
作者:
庄 薇1; 姚荣华1; 周俊平2
(1.解放军联勤保障部队第九〇一医院产科,安徽 合肥 230031; 2.解放军联勤保障部队第九〇一医院内科,安徽 合肥 230031)
Author(s):
ZHUANG Wei1; YAO Ronghua1; ZHOU Junping2
(1.Department of Obstetrics,901st Hospital,the PLA Joint Logistic Support Force,Hefei 230031,China; 2.Department of Internal Medicine,901st Hospital,the PLA Joint Logistic Support Force,Hefei 230031,China)
关键词:
妊娠期亚临床甲状腺功能减退症;  成纤维细胞生长因子21;  脂质运载蛋白-2;  凝血功能;  妊娠结局
Keywords:
Subclinical hypothyroidism during pregnancy;  Fibroblast growth factor 21;  Lipocalin-2;  Coagulation function;  Pregnancy outcomes
分类号:
R 714.256
DOI:
DOI:10.3969/j.issn.1000-7377.2025.05.012
文献标志码:
A
摘要:
目的:探讨血清成纤维细胞生长因子21(FGF21)、脂质运载蛋白-2(LCN2)和凝血功能与妊娠期亚临床甲状腺功能减退症(SCH)患者妊娠结局的关系。方法:选取142例妊娠期SCH患者为SCH组,并依据妊娠结局将其分为正常妊娠结局组(43例)和不良妊娠结局组(99例),另选取102例同期健康产妇为对照组。比较各组血清FGF21、LCN2水平及凝血功能指标。比较对照组和SCH组糖脂代谢指标。妊娠期SCH患者妊娠结局的影响因素采用多因素Logistic回归进行分析。Pearson法分析妊娠期SCH患者血清FGF21、LCN2、纤维蛋白原(FIB)与甲状腺过氧化物酶抗体(TPOAb)、甲状腺球蛋白抗体(TgAb)水平的相关性。结果:SCH组血清FGF21、LCN2、FIB水平高于对照组(均P<0.05)。SCH组空腹血糖(FPG)、2 h餐后血糖(PBG)、胰岛素抵抗指数(HOMA-IR)、胆固醇(TC)、低密度脂蛋白(LDL-C)水平高于对照组(均P<0.05)。与正常妊娠结局组比较,不良妊娠结局组血清FGF21、LCN2、FIB、TPOAb、TgAb水平升高(均P<0.05)。血清FGF21、LCN2、FIB、TPOAb、TgAb是SCH孕妇妊娠结局的独立影响因素(均P<0.05)。血清FGF21、LCN2、FIB与TPOAb、TgAb水平呈正相关(均P<0.05)。结论:妊娠期SCH患者血清FGF21、LCN2、FIB水平升高,且三者是SCH孕妇妊娠结局的影响因素。
Abstract:
Objective:To investigate the relationship between serum fibroblast growth factor 21(FGF21),lipocalin-2(LCN2),coagulation function and pregnancy outcomes in patients with subclinical hypothyroidism(SCH)during pregnancy.Methods:A total of 142 pregnant women with SCH were enrolled in the SCH group,which was further divided into normal pregnancy outcome group(43 cases)and adverse pregnancy outcome group(99 cases).Another 102 healthy pregnant women from the same period were selected as the control group.Serum levels of FGF21,LCN2 and coagulation function indicators were compared among the groups.Metabolic indicators of glucose and lipid metabolism were compared between the control and SCH groups.Factors influencing pregnancy outcomes in pregnant women with SCH were analyzed using multivariate logistic regression.Pearson correlation analysis was used to assess the correlation between serum FGF21,LCN2,fibrinogen(FIB)and thyroid peroxidase antibody(TPOAb)and thyroglobulin antibody(TgAb)levels in pregnant women with SCH.Results:Serum levels of FGF21,LCN2 and FIB were higher in the SCH group than in the control group(all P<0.05).The SCH group also had higher levels of fasting plasma glucose(FPG),2-hour postprandial glucose(PBG),homeostasis model assessment of insulin resistance(HOMA-IR),total cholesterol(TC)and low-density lipoprotein cholesterol(LDL-C)compared with the control group(all P<0.05).Compared with the normal pregnancy outcome group,the adverse pregnancy outcome group had higher levels of serum FGF21,LCN2,FIB,TPOAb and TgAb(all P<0.05).Serum FGF21,LCN2,FIB,TPOAb and TgAb were identified as independent influencing factors for pregnancy outcomes in SCH pregnant women(all P<0.05).Serum FGF21,LCN2 and FIB levels were positively correlated with TPOAb and TgAb levels(all P<0.05).Conclusion:Elevated serum levels of FGF21,LCN2 and FIB are observed in pregnant women with SCH,and these three factors are associated with pregnancy outcomes in SCH patients.

参考文献/References:

[1] SHI D,DU J,KANG H,et al.The effect of subclinical hypothyroidism on hormonal and metabolic profiles and ovarian morphology in patients with polycystic ovary syndrome:A cross-sectional study[J].Gynecol Endocrinol,2024,40(1):2358219.
[2] PRIYANKA R,SAGILI H,SAHOO J,et al.Pregnancy outcome in subclinical hypothyroidism with and without thyroid peroxidase antibodies-a prospective cohort study[J].Arch Gynecol Obstet,2024,310(4):1935-1944.
[3] 房秋霞,舒展,杨金铭,等.妊娠期亚临床甲状腺功能减退症对妊娠结局和胎儿不良影响研究[J].陕西医学杂志,2018,47(3):338-340,343.
[4] 赵云虹,侯临平,李盛华,等.血清成纤维细胞生长因子-21、亚甲基四氢叶酸还原酶基因多态性与妊娠期亚临床甲状腺功能减退症的相关性[J].中国医药导报,2024,21(15):88-91.
[5] 吕飞娟,王佑民.亚临床甲状腺功能减退合并妊娠期糖尿病的临床研究[J].中国临床药理学杂志,2018,34(12):1404-1406.
[6] 彭锦.促甲状腺素、25-羟基维生素D水平、TPOAb、HCG在妊娠期糖尿病合并亚临床甲减患者中的表达及临床意义[J].中外女性健康研究,2024(9):71-73.
[7] 章远谋,韩康,夏瑞,等.亚临床甲状腺功能减退症对多囊卵巢综合征患者内分泌代谢特征的影响[J].基础医学与临床,2023,43(4):641-646.
[8] 何逸俊,魏华.甲状腺功能亢进患者的中医症型分布特点及与甲功、血脂相关性分析[J].陕西中医,2024,45(9):1190-1194.
[9] 中华医学会内分泌学分会,中华医学会围产医学分会.妊娠和产后甲状腺疾病诊治指南[J].中华内分泌代谢杂志,2012,28(5):354-371.
[10] 田小红,方华英,陈慧君,等.农村山区生育二孩或三孩孕妇亚临床甲状腺功能减退症的发生情况及影响因素分析[J].生殖医学杂志,2024,33(7):961-964.
[11] HANDER S,LEE S Y.Risk of progression of gestational subclinical hypothyroidism and hypothyroxinemia to overt hypothyroidism after pregnancy is associated with underlying thyroid autoimmunity[J].Thyroid,2024,34(9):1066-1067.
[12] 韩曦,康佳,何小荣,等.不同诊断标准下妊娠早期亚临床甲状腺功能减退及甲状腺过氧化物酶抗体表达对妊娠结局的影响[J].陕西医学杂志,2022,51(7):843-847.
[13] 张瑞倩,李洲婷.成纤维细胞生长因子-21甲状腺过氧化物酶抗体及25-羟维生素D在妊娠期甲状腺功能减退症中的表达及意义[J].中国妇幼保健,2024,39(10):1866-1869.
[14] 张瑞倩.血清甲状腺激素成纤维细胞生长因子-21环氧化酶-2在妊娠合并亚临床甲状腺功能减退中的水平及相关性研究[J].中国妇幼保健,2024,39(1):18-22.
[15] 汤春梦,曹辉,鲁佳,等.妊娠合并甲状腺功能减退孕妇FGF-21、Hcy水平及与甲状腺激素水平关系[J].中国计划生育学杂志,2023,31(7):1732-1736.
[16] 韩正芳.妊娠合并亚临床甲状腺功能减退症患者血清甲状腺激素、血脂、成纤维细胞生长因子-21水平及临床意义[J].中国妇幼保健,2022,37(19):3542-3545.
[17] 杨菊梅,李永莉.FGF-21、Apelin在妊娠合并甲减患者血清中的水平表达及其与血脂水平、低体重新生儿发生率的相关性分析[J].医学临床研究,2021,38(5):724-726,730.
[18] 康乐,孙安琪.妊娠期SCH患者血脂、RE及lipocalin-2水平变化及临床意义分析[J].保健医学研究与实践,2022,19(10):90-93.
[19] 任国华,陈维萍,李静,等.脂质运载蛋白2及其受体表达与妊娠期糖尿病孕妇胰岛素抵抗的关系[J].中华妇产科杂志,2012,47(11):851-854.
[20] 付文君,李珂,于晶晶.妊娠合并甲状腺功能减退患者血清apelin、lipocalin-2表达及与血脂关系分析[J].宁夏医学杂志,2021,43(12):1164-1166.
[21] 于燕,张锐,卫焱星,等.妊娠期糖尿病孕妇血清脂质运载蛋白-2水平变化及临床意义初探[J].现代生物医学进展,2012,12(24):4735-4737,4751.
[22] 张素芹,姜萍,赵明瑜,等.妊娠期糖尿病并发子痫前期患者胎盘组织抵抗素、人脂质运载蛋白及血糖脂代谢检测价值[J].中华内分泌外科杂志,2022,16(5):627-632.
[23] 褚雪莲,毕芬燕,王益凤,等.妊娠糖尿病合并甲状腺功能减退孕妇的凝血功能指标表达及价值研究[J].中国卫生检验杂志,2021,31(6):719-722.
[24] DE-LUCA M,D'ASSANTE R,IACOVIELLO M,et al.Correction:Subclinical hypothyroidism predicts outcome in heart failure:Insights from the T.O.S.CA.registry[J].Intern Emerg Med,2024,19(6):1787-1788.
[25] 高春利,窦娟,许聃聃,等.血清IGF-1、TPOAb、TgAb水平检测在妊娠期糖尿病合并亚临床甲减患者中的意义[J].实验与检验医学,2021,39(5):1176-1178,1190.
[26] 段蓓,王敏,郑福利.妊娠期糖尿病合并甲状腺功能减退孕妇脂代谢、凝血功能指标的变化分析[J].贵州医药,2024,48(1):65-67.
[27] 尹进波,周宗爱,汤智越,等.妊娠合并甲状腺功能减退患者血清apelin、lipocalin-2表达及与血脂关系[J].中国计划生育学杂志,2019,27(3):355-358.

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备注/Memo

备注/Memo:
[基金项目]安徽省卫生健康委员会医学科学研究计划项目(2021SF-1062)
更新日期/Last Update: 2025-05-05