[1]吴秀娟,韩 娜,菅辉玲,等.血清可溶性髓系细胞触发受体1、磷脂酶A2及国家早期预警评分对重症肺炎所致呼吸窘迫综合征患者预后的评估价值[J].陕西医学杂志,2025,54(4):550-554.[doi:DOI:10.3969/j.issn.1000-7377.2025.04.023]
　WU Xiujuan,HAN Na,KAN Huiling,et al.Prognostic value of serum soluble myeloid cell trigger receptor 1,phospholipase A2 and NEWS score in ARDS patients with severe pneumonia[J].,2025,54(4):550-554.[doi:DOI:10.3969/j.issn.1000-7377.2025.04.023]
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血清可溶性髓系细胞触发受体1、磷脂酶A2及国家早期预警评分对重症肺炎所致呼吸窘迫综合征患者预后的评估价值
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《陕西医学杂志》[ISSN:1000-7377/CN:61-1281/TN]

卷:
54
期数:
2025年4期
页码:
550-554
栏目:
临床检验
出版日期:
2025-04-05

文章信息/Info

Title:
Prognostic value of serum soluble myeloid cell trigger receptor 1,phospholipase A2 and NEWS score in ARDS patients with severe pneumonia
作者:
吴秀娟1; 韩 娜1; 菅辉玲1; 马宏鹰1; 张大军2
(1.克拉玛依市中心医院检验科,新疆 克拉玛依 834000; 2.克拉玛依市中心医院健康管理中心,新疆 克拉玛依 834000)
Author(s):
WU Xiujuan1; HAN Na1; KAN Huiling1; MA Hongying1; ZHANG Dajun2
(1.Department of Clinical Laboratory,Karamay Central Hospital,Karamay 834000,China; 2.Health Management Center,Karamay Central Hospital,Karamay 834000,China)
关键词:
重症肺炎;  急性呼吸窘迫综合征;  可溶性髓系细胞触发受体1;  磷脂酶A2;  国家早期预警评分;  预后
Keywords:
Severe pneumonia;  Acute respiratory distress syndrome;  Triggering receptor expressed on myeloid cells-1;  Phospholipase A2;  National early warning score;  Prognosis
分类号:
R 563.1
DOI:
DOI:10.3969/j.issn.1000-7377.2025.04.023
文献标志码:
A
摘要:
目的:探讨血清可溶性髓系细胞触发受体1(sTREM-1)、磷脂酶A2(PLA2)及国家早期预警评分(NEWS)对重症肺炎(SP)所致急性呼吸窘迫综合征(ARDS)患者预后的评估价值。方法:选取SP所致ARDS患者143例为ARDS组,另选64例同期健康体检者为对照组。比较对照组和ARDS组患者的血清sTREM-1、PLA2水平和NEWS评分,对SP所致ARDS患者预后不良的危险因素进行多因素Logistic回归分析。结果:与对照组比较,ARDS组患者血清sTREM-1、PLA2水平、NEWS评分出现显著升高(均P<0.05)。两组年龄、性别、吸烟史、饮酒史、高血压史、冠心病史、糖尿病史、高脂血症、舒张压、收缩压之间比较无统计学差异(均P>0.05),预后不良组患者机械通气时间明显较长(P<0.05),血清sTREM-1、PLA2水平、NEWS评分明显升高(均P<0.05)。机械通气时间长、高血清sTREM-1、PLA2水平、高NEWS评分是PSUI发生的危险因素(均P<0.05)。血清sTREM-1、PLA2联合NEWS评分对SP所致ARDS患者预后的评估价值明显高于三者独立检测(均P<0.05)。结论:SP所致ARDS患者预后不良的危险因素包括机械通气时间长、高血清sTREM-1、PLA2水平、高NEWS评分。血清sTREM-1、PLA2联合NEWS评分对SP所致ARDS患者预后具有较高的评估价值。
Abstract:
Objective:Objective To evaluate the prognostic value of serum soluble myeloid cell trigger receptor 1(sTREM-1),phospholipase A2(PLA2)and national early warning(NEWS)scores in patients with acute respiratory distress syndrome(ARDS)caused by severe pneumonia(SP).Methods:A total of 143 patients with ARDS caused by SP were selected as ARDS group and 64 healthy subjects were selected as control group.The levels of serum sTREM-1,PLA2 and NEWS scores of ARDS patients in control group and ARDS group were compared,and the risk factors of poor prognosis of ARDS patients with SP were analyzed by multivariate Logistic regression.Results:Compared with control group,serum levels of sTREM-1,PLA2 and NEWS score in ARDS group were significantly increased(all P<0.05).There were no significant differences between the two groups in age,gender,smoking history,drinking history,hypertension history,coronary heart disease history,diabetes history,hyperlipidemia,diastolic blood pressure and systolic blood pressure(all P>0.05),and the mechanical ventilation time of patients with poor prognosis was significantly longer(P<0.05).Serum levels of sTREM-1,PLA2 and NEWS scores were significantly increased(all P<0.05).Long mechanical ventilation time,high serum sTREM-1,PLA2 levels and high NEWS score were the risk factors for PSUI(all P<0.05).Serum sTREM-1 and PLA2 combined NEWS scores were significantly higher in evaluating the prognosis of ARDS patients with SP than the three independent tests(all P<0.05).Conclusion:Serum sTREM-1 and PLA2 combined NEWS scores have high prognostic value in ARDS patients with SP,and are worthy of clinical promotion and use.

参考文献/References:

[1] LI G,CHEN D,GAO F,et al.Efficacy of corticosteroids in patients with acute respiratory distress syndrome:A meta-analysis[J].Ann Med,2024,56(1):2381086.
[2] LI N N,KANG K,ZHOU Y,et al.Throat microbiota drives alterations in pulmonary alveolar microbiota in patients with septic ARDS[J].Virulence,2024,15(1):2350775.
[3] 王小芳,张利军.可溶性人髓系细胞触发受体1、可溶性血红蛋白清道夫受体、降钙素原表达水平对肝硬化合并自发性细菌性腹膜炎的诊断价值[J].陕西医学杂志,2021,50(12):1525-1527.
[4] 谢波,高颖.经鼻高流量湿化氧疗联合肺泡灌洗治疗重症肺炎合并呼吸衰竭患者疗效观察[J].陕西医学杂志,2023,52(1):49-52.
[5] 杨玉嘉,董宝军,屈金辉,等.血清Lp-PLA2对肺炎相关急性呼吸窘迫综合征诊断分级和预后评估的价值[J].临床检验杂志,2024,42(8):580-585.
[6] 季燕,朱锋,宋建华.高迁移率族蛋白B1、脂蛋白相关磷脂酶A2、中性粒细胞与淋巴细胞比值诊断高血压患者合并急性脑梗死的价值及其与病情严重程度的关系研究[J].实用心脑肺血管病杂志,2023,31(12):75-79.
[7] 王萌,刘利欣,杨旭芬,等.国家预警评分系统联合白蛋白预测急性心力衰竭患者不良预后的价值[J].心肺血管病杂志,2024,43(7):695-699,730.
[8] 段均.急性呼吸窘迫综合征患者机械通气指南(试行)解读[J].重庆医科大学学报,2017,42(1):76-78.
[9] 谢丽莹,麦彤,周耿标,等.中医药治疗脓毒症性急性肺损伤/急性呼吸窘迫综合征临床试验结局指标分析与思考[J].中国全科医学,2024,27(27):3418-3427.
[10] ZHAO Y,YAO Z,XU S,et al.Glucocorticoid therapy for acute respiratory distress syndrome:Current concepts[J].J Intensive Med,2024,4(4):417-432.
[11] HALTER S,ROSENZWAJG M,KLATZMANN D,et al.Regulatory T cells in acute respiratory distress syndrome:Current status and potential for future immunotherapies[J].Anesthesiology,2024,141(4):755-764.
[12] 邓爱兵,李绚梅,宋健,等.成人重症肺炎患者血清降钙素原、IL-17、sTREM-1水平的变化及临床意义[J].临床和实验医学杂志,2024,23(14):1498-1501.
[13] 付靖瑜,柯俊,陈伟,等.阿米卡星联合哌拉西林钠/他唑巴坦钠治疗重症肺炎的疗效及对血清HMGB1、sTREM-1、miR-233的影响[J].临床和实验医学杂志,2024,23(13):1376-1381.
[14] 田静,袁浩.成年重症肺炎合并呼吸衰竭患者血清中sTREM-1、TLR4、VCAM-1的表达及对预后的评估价值[J].中国医师杂志,2024,26(5):707-711.
[15] 王彩霞,田玉晶,未会朵,等.血清sTREM-1、NT-BNP与LTB4水平在慢性阻塞性肺疾病急性加重期并发心力衰竭中的诊断价值[J].临床和实验医学杂志,2023,22(24):2585-2589.
[16] 胡苏衡,张浩,谢东升,等.肺CT联合血清Copeptin、sTREM-1检测对COPD合并Ⅱ型呼吸衰竭患者疗效评估及预后价值[J].中国CT和MRI杂志,2023,21(11):70-73.
[17] 王文法,杨泳,王莉,等.七氟醚下调TRPV4/C-PLA2信号通路活性减轻呼吸机诱导的大鼠肺损伤[J].南方医科大学学报,2023,43(11):1886-1891.
[18] 沈建华,程储记.血清磷脂酶A2、降钙素原和白细胞介素6、10因子对重症肺炎患者预后的预测价值[J].中国医药导报,2023,20(8):119-123.
[19] 龙超,叶广勤.前白蛋白联合脂蛋白相关磷脂酶A2预测老年社区获得性肺炎临床分析[J].中华肺部疾病杂志:电子版,2020,13(6):800-802.
[20] 徐琳,路苹,姚红梅,等.支气管扩张症合并感染患者血清人分泌型磷脂酶A2-X表达情况及其与炎性指标的相关性研究[J].中国全科医学,2020,23(24):3034-3039.
[21] 胡玉婷,温成平,江婷婷,等.血清磷脂酶A2组ⅡA和凝血因子Ⅸ筛查耐多药肺结核病气阴两虚证的应用研究[J].浙江中医药大学学报,2019,43(5):440-446.
[22] 郭青,沈照波,孙晓敏,等.胞浆型磷脂酶A2多态性与儿童支气管哮喘发生及孟鲁司特疗效的相关性[J].中国当代儿科杂志,2019,21(2):155-160.
[23] YILDIRIM O,SAHIN A,TATAR S D,et al.Comparison of Manchester,qSOFA,emergency severity index,and national early warning scores for prognostic estimation and effective triage system in geriatric patients[J].Ir J Med Sci,2024,193(4):2051-2059.
[24] 王威,张灯亮,夏岩,等.不同评分系统对老年社区获得性肺炎患者转入ICU和死亡率的预测效能比较[J].临床肺科杂志,2024,29(8):1178-1182.
[25] 张鸥,周峰,周祥林,等.血清sICAM-1水平联合国家早期预警评分对重症肺炎所致ARDS患者预后的评估价值[J].山东医药,2023,63(22):13-16.

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备注/Memo

备注/Memo:
[基金项目]新疆维吾尔自治区重点研发项目(2023GHD-1058)
更新日期/Last Update: 2025-04-07