[1]马 南,周冰洁,张建银.血清Toll样受体4、氨基末端脑钠肽前体、甲壳质酶蛋白40水平与慢性阻塞性肺疾病患者急性加重期治疗预后的相关性[J].陕西医学杂志,2025,54(4):502-506.[doi:DOI:10.3969/j.issn.1000-7377.2025.04.013]
　MA Nan,ZHOU Bingjie,ZHANG Jianyin.Correlation between serum TLR4,NT-proBNP,YKL-40 levels and prognosis of patients with acute COPD exacerbation[J].,2025,54(4):502-506.[doi:DOI:10.3969/j.issn.1000-7377.2025.04.013]
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血清Toll样受体4、氨基末端脑钠肽前体、甲壳质酶蛋白40水平与慢性阻塞性肺疾病患者急性加重期治疗预后的相关性
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《陕西医学杂志》[ISSN:1000-7377/CN:61-1281/TN]

卷:
54
期数:
2025年4期
页码:
502-506
栏目:
临床研究
出版日期:
2025-04-05

文章信息/Info

Title:
Correlation between serum TLR4,NT-proBNP,YKL-40 levels and prognosis of patients with acute COPD exacerbation
作者:
马 南1; 周冰洁2; 张建银3
(1.滨州市人民医院呼吸与危重症医学科,山东 滨州 256600; 2.滨州市人民医院儿科,山东 滨州 256600; 3.宁夏回族自治区人民医院呼吸与危重症医学科,宁夏 银川 750021)
Author(s):
MA Nan1; ZHOU Bingjie2; ZHANG Jianyin3
(1.Department of Respiratory and Critical Care Medicine,Binzhou People's Hospital,Binzhou 256600,China; 2.Department of Pediatrics,Binzhou People's Hospital,Binzhou 256600,China; 3.Department of Respiratory and Critical Care Medicine,Ningxia Hui Autonomous Region People's Hospital,Yinchuan 750021,China)
关键词:
慢性阻塞性肺疾病急性加重期;  Toll样受体4;  氨基末端脑钠肽前体;  甲壳质酶蛋白40;  预后;  相关性
Keywords:
Acute exacerbation chronic obstructive pulmonary disease;  Toll-like receptor 4;  N-Terminal pro-brain natriuretic peptide;  Human cartilage glycoprotein-40;  Prognosis;  Correlation
分类号:
R 563.5
DOI:
DOI:10.3969/j.issn.1000-7377.2025.04.013
文献标志码:
A
摘要:
目的:探讨血清Toll样受体4(TLR4)、氨基末端脑钠肽前体(NT-proBNP)、甲壳质酶蛋白40(YKL-40)水平与慢性阻塞性肺疾病急性加重期(AECOPD)患者治疗预后的相关性。方法:选取AECOPD患者142例为AECOPD组,另选92例同期健康体检者为对照组。比较两组受试者血清TLR4、NT-proBNP、YKL-40水平,多因素Logistic回归分析AECOPD患者预后不良的影响因素。结果:与对照组比较,AECOPD组患者血清TLR4、NT-proBNP、YKL-40水平升高(均P<0.05)。预后良好组与预后不良组比较,心力衰竭患者占比增加,血清TLR4、NT-proBNP、YKL-40水平升高(均P<0.05)。心力衰竭、高血清TLR4、NT-proBNP、YKL-40水平是AECOPD患者预后不良的危险因素(均P<0.05)。AECOPD患者血清TLR4、NT-proBNP、YKL-40水平均与患者预后不良呈正相关(均P>0.05)。结论:AECOPD患者血清TLR4、NT-proBNP、YKL-40水平显著升高,高血清TLR4、NT-proBNP、YKL-40水平是其预后不良的危险因素,且与患者预后不良呈正相关。
Abstract:
Objective:To investigate the correlation between serum levels of Toll-like receptor 4(TLR4),amino-terminal brain natriuretic peptide precursor(NT-proBNP)and chitinase protein 40(YKL-40)and the prognosis of patients with acute exacerbation of chronic obstructive pulmonary disease(AECOPD).Methods:A total of 142 patients with AECOPD were selected as AECOPD group,and 92 healthy subjects were selected as control group.Serum levels of TLR4,NT-proBNP and YKL-40 were compared between the two groups,and the influencing factors of poor prognosis in patients with AECOPD were analyzed by multivariate Logistic regression.Results:Compared with the control group,the levels of serum TLR4,NT-proBNP and YKL-40 in AECOPD group were significantly increased(P<0.05).Compared with the good prognosis group,the proportion of patients with heart failure,serum TLR4,NT-proBNP and YKL-40 levels in the poor prognosis group were significantly increased(all P<0.05).Heart failure,high serum TLR4,NT-proBNP,YKL-40 levels were the risk factors for poor prognosis in AECOPD patients(P<0.05).Serum levels of TLR4,NT-proBNP and YKL-40 in AECOPD patients were positively correlated with poor prognosis(P>0.05).Conclusion:Serum levels of TLR4,NT-proBNP and YKL-40 in AECOPD patients were significantly increased,and high serum levels of TLR4,NT-proBNP and YKL-40 were risk factors for poor prognosis,and were positively correlated with poor prognosis.

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备注/Memo

备注/Memo:
[基金项目]山东省卫生健康委员会科研项目(2021KH-1266); 山东省滨州市人民医院院级课题(LCYJZR202119)
更新日期/Last Update: 2025-04-07