[1]陈京京,陈盈玲,单浩杰,等.2型糖尿病患者连续血糖监测目标范围内时间与血清骨钙素N端中分子片段、Ⅰ型前胶原氨基端前肽相关性研究[J].陕西医学杂志,2025,54(3):319-322,327.[doi:DOI:10.3969/j.issn.1000-7377.2025.03.006]
　CHEN Jingjing,CHEN Yingling,SHAN Haojie,et al.Correlation between TIR and serum N-MID OC,PINP in patients with type 2 diabetes mellitus[J].,2025,54(3):319-322,327.[doi:DOI:10.3969/j.issn.1000-7377.2025.03.006]
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2型糖尿病患者连续血糖监测目标范围内时间与血清骨钙素N端中分子片段、Ⅰ型前胶原氨基端前肽相关性研究
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《陕西医学杂志》[ISSN:1000-7377/CN:61-1281/TN]

卷:
54
期数:
2025年3期
页码:
319-322,327
栏目:
临床研究
出版日期:
2025-03-05

文章信息/Info

Title:
Correlation between TIR and serum N-MID OC,PINP in patients with type 2 diabetes mellitus
作者:
陈京京1; 2; 陈盈玲1; 2; 单浩杰2; 蒋伏松1; 2; 于晓巍2
(1.江西中医药大学,江西 南昌 330004; 2.上海交通大学医学院附属第六人民医院,上海 200233)
Author(s):
CHEN Jingjing1; 2; CHEN Yingling1; 2; SHAN Haojie2; JIANG Fusong1; 2; YU Xiaowei2
(1.Jiangxi University of Chinese Medicine,Nanchang 330004,China; 2.The Sixth Affiliated People's Hospital of Medical School,Shanghai Jiaotong University,Shanghai 200233,China)
关键词:
2型糖尿病;  骨形成标志物;  骨钙素N端中分子片段;  Ⅰ型前胶原氨基端前肽;  连续血糖监测
Keywords:
Type 2 diabetes mellitus;  Bone formation markers;  N-terminal mid-fragment of osteocalcin;  Propeptide of type Ⅰ procollage;  Continuous glucose monitoring
分类号:
R 587.1
DOI:
DOI:10.3969/j.issn.1000-7377.2025.03.006
文献标志码:
A
摘要:
目的:探讨2型糖尿病(T2DM)患者连续血糖监测(CGM)目标范围内时间(TIR)与骨形成标志物血清骨钙素N端中分子片段(N-MID OC)和Ⅰ型前胶原氨基端前肽(PINP)之间的关系。方法:选取住院T2DM患者336例为研究对象,均接受72 h连续血糖监测,并计算TIR。根据TIR水平将患者分为TIR<70%组(154例)和TIR≥70%组(182例)。检测所有患者血清N-MID OC、PINP和其他生化指标水平。TIR与N-MID OC、PINP的相关性采用Pearson相关性分析和多元线性回归分析进行。结果:TIR<70%组N-MID OC、PINP水平低于TIR≥70%组(均P<0.05)。Pearson相关性分析结果显示,TIR与N-MID OC、PINP呈正相关(均P<0.05)。调整与骨质疏松和糖尿病发生密切相关因素后,多元线性回归分析结果显示,TIR仍与N-MID OC、PINP存在正相关关系(均P<0.05)。结论:T2DM患者TIR与骨形成指标物N-MID OC和PINP水平呈正相关。
Abstract:
Objective:To investigate the relationship between time in range(TIR)within continuous glucose monitoring(CGM)and the N-terminal mid-fragment of osteocalcin(N-MID OC)and propeptide of type Ⅰ procollage(PINP)in patients with type 2 diabetes mellitus(T2DM).Methods:A total of 336 hospitalized patients with T2DM were selected as the study subjects,all of whom received 72-hour CGM,and TIR was calculated.Patients were divided into TIR <70% group(154 cases)and TIR ≥70% group(182 cases)according to their TIR levels.Serum N-MID OC,PINP and other biochemical indexes were detected in all patients.The correlation between TIR and N-MID OC,PINP was performed by Pearson correlation analysis and multiple linear regression analysis.Results:The levels of N-MID OC and PINP in TIR <70% group were lower than those in TIR ≥70% group(all P<0.05).Pearson correlation analysis showed that TIR was positively correlated with N-MID OC and PINP(all P<0.05).After adjusting the factors closely related to osteoporosis and diabetes,the results of multiple linear regression analysis showed that TIR was still positively correlated with N-MID OC and PINP(all P<0.05).Conclusion:TIR was positively correlated with N-MID OC and PINP levels in T2DM patients.

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备注/Memo

备注/Memo:
[基金项目]国家自然科学基金资助项目(82372387); 上海交通大学医工交叉研究基金资助项目(YG2024ZD19)
更新日期/Last Update: 2025-03-05