[1]王 贝,姜 力,李依玲,等.单肺通气致肺损伤的机制及保护策略研究进展[J].陕西医学杂志,2025,54(1):138-141.[doi:DOI:10.3969/j.issn.1000-7377.2025.01.028]
　WANG Bei,JIANG Li,LI Yiling,et al.Research progress on the mechanism and protective strategies of lung injury caused by single-lung ventilation[J].,2025,54(1):138-141.[doi:DOI:10.3969/j.issn.1000-7377.2025.01.028]
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单肺通气致肺损伤的机制及保护策略研究进展
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《陕西医学杂志》[ISSN:1000-7377/CN:61-1281/TN]

卷:
54
期数:
2025年1期
页码:
138-141
栏目:
综 述
出版日期:
2025-01-05

文章信息/Info

Title:
Research progress on the mechanism and protective strategies of lung injury caused by single-lung ventilation
作者:
王 贝1; 2; 姜 力3; 李依玲1; 孟 杰1
(1.武汉科技大学附属孝感医院,湖北 孝感 432000; 2.武汉科技大学医学部医学院,湖北 武汉 430065; 3.武汉大学附属同仁医院普外科,湖北 武汉 430060)
Author(s):
WANG Bei; JIANG Li; LI Yiling; MENG Jie
(Wuhan University of Science and Technology Affiliated Xiaogan Hospital,Xiaogan 432000,China)
关键词:
单肺通气;  肺损伤;  机制;  保护策略;  研究进展
Keywords:
Single-lung ventilation;  Lung injury;  Mechanism;  Protection strategy;  Research progress
分类号:
R 563
DOI:
DOI:10.3969/j.issn.1000-7377.2025.01.028
文献标志码:
A
摘要:
单肺通气(OLV)是临床常见的一种通气技术,能够有效隔离患侧肺,实现对非手术侧肺通气的目的。目前,OLV广泛应用于各类大型手术中,有效提高了手术的有效性与安全性。但OLV在应用过程中易造成肺损伤,常见的肺损伤类型有肺不张损伤、灌注性肺损伤、氧化应激肺损伤、手术操作致肺损伤、高容量肺损伤,多种类型的肺损伤发病机制具有复杂性,根据肺损伤机制临床可制定吸入合适的氧浓度、选择有效的通气模式、潮气量、持续正压气道、呼气末正压等一系列肺保护策略,能够逐步提高氧合功能,减轻肺损伤,加速肺损伤组织的修复。
Abstract:
Single-lung ventilation(OLV)is a common ventilation technique in clinic,which can effectively isolate the affected lung and achieve the purpose of ventilating the non-operative lung.At present,OLV is widely used in various large-scale operations,which effectively improves the effectiveness and safety of the operation.However,OLV is easy to cause lung injury in the application process.The common types of lung injury are atelectasis,perfusion,oxidative stress,operation and high-volume lung injury.The pathogenesis of various types of lung injury is complex.According to the mechanism of lung injury,a series of lung protection strategies can be formulated in clinic,such as inhaling appropriate oxygen concentration,selecting effective ventilation mode,tidal volume,continuous positive airway pressure and positive end-expiratory pressure,which can gradually improve oxygenation function and relieve lung.

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备注/Memo

备注/Memo:
基金项目:湖北省卫生健康委员会科研项目(WJ20210169)
更新日期/Last Update: 2025-01-06