[1]侯红霞,赵 梦,陆银宝.血清乳酸脱氢酶、肌酸激酶同工酶与病毒性心肌炎患者病情严重程度及不良预后的关系[J].陕西医学杂志,2025,54(1):118-122.[doi:DOI:10.3969/j.issn.1000-7377.2025.01.024]
　HOU Hongxia,ZHAO Meng,LU Yinbao.The relationship between serum LDH,CK-MB and the severity and adverse prognosis of viral myocarditis patients[J].,2025,54(1):118-122.[doi:DOI:10.3969/j.issn.1000-7377.2025.01.024]
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血清乳酸脱氢酶、肌酸激酶同工酶与病毒性心肌炎患者病情严重程度及不良预后的关系
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《陕西医学杂志》[ISSN:1000-7377/CN:61-1281/TN]

卷:
54
期数:
2025年1期
页码:
118-122
栏目:
临床检验
出版日期:
2025-01-05

文章信息/Info

Title:
The relationship between serum LDH,CK-MB and the severity and adverse prognosis of viral myocarditis patients
作者:
侯红霞1; 2; 赵 梦1; 2; 陆银宝3
(1.徐州医科大学附属淮安医院临检中心,江苏 淮安 223002; 2.淮安市第二人民医院临检中心,江苏 淮安 223002; 3.淮安市妇幼保健院,江苏 淮安 223022)
Author(s):
HOU Hongxia; ZHAO Meng; LU Yinbao
(Clinical Inspection Center,Huai'an Hospital,Xuzhou Medical University,Huai'an 223002,China)
关键词:
乳酸脱氢酶;  肌酸激酶同工酶;  病毒性心肌炎;  病情;  预后;  影响因素
Keywords:
Lactate dehydrogenase;  Creatine kinase MB;  Viral myocarditis;  Illness;  Prognosis;  Influencing factors
分类号:
R 542.2
DOI:
DOI:10.3969/j.issn.1000-7377.2025.01.024
文献标志码:
A
摘要:
目的:探究血清乳酸脱氢酶(LDH)、肌酸激酶同工酶(CK-MB)与病毒性心肌炎患者病情严重程度及不良预后的关系。方法:选取172例病毒性心肌炎患者,根据病情严重程度分为轻症组92例和重症组80例,比较血清LDH、CK-MB水平变化,对研究对象进行12个月的随访,根据预后情况分为预后良好组100例,预后不良组72例,比较两组患者临床资料,以Cox回归分析血清LDH、CK-MB与病毒性心肌炎患者不良预后的相关性。结果:轻症组患者的血清LDH、CK-MB均低于重症组,差异具有统计学意义(均P<0.05)。预后良好组收缩压、舒张压高于预后不良组,血清肌钙蛋白I(cTnI)、肌红蛋白(MYO)、LDH、CK-MB水平及心律失常患者占比低于预后不良组,差异有统计学意义(均P<0.05)。Cox回归分析结果显示,收缩压、心率失常、cTnI、LDH≥184.93 U/L、CK-MB≥43.48 U/L是影响病毒性心肌炎患者不良预后的危险因素(均P<0.05)。结论: 病毒性心肌炎患者血清LDH、CK-MB与病情严重程度及不良预后有关,血清LDH、CK-MB越高,病情越严重,且不良预后的发生风险也随之提升。
Abstract:
Objective:To explore the relationship between serum lactate dehydrogenase(LDH)and creatine kinase isoenzyme(CK-MB)and the severity of disease and poor prognosis in patients with viral myocarditis.Methods:A total of 172 patients with viral myocarditis were selected and divided into a mild group(92 cases)and a severe group(80 cases)according to the severity of the disease.The changes of serum LDH and CK-MB levels were compared.The subjects were followed up for 12 months and divided into a good prognosis group(100 cases)and a poor prognosis group(72 cases)according to the prognosis.Cox regression was used to analyze the correlation between serum LDH,CK-MB and poor prognosis in patients with viral myocarditis.Results:Serum LDH and CK-MB in mild group were lower than those in severe group,and the differences were statistically significant(all P<0.05).The systolic blood pressure and diastolic blood pressure of the good prognosis group were higher than those of the poor prognosis group,and the levels of serum cTnI,MYO,LDH,CK-MB and the proportion of arrhythmia patients were lower than those of the poor prognosis group,with statistical significance(all P<0.05).Cox regression analysis showed that systolic blood pressure,arrhythmia,cTnI,LDH≥184.93 U/L,CK-MB≥43.48 U/L were risk factors for adverse prognosis in patients with viral myocarditis(all P<0.05).Conclusion:Serum LDH and CK-MB are related to the severity of disease and poor prognosis of patients with viral myocarditis.The higher the serum LDH and CK-MB,the more serious the disease,and the risk of poor prognosis is also increased.

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备注/Memo

备注/Memo:
基金项目:江苏省自然科学基金资助项目(HD2022FE032)
更新日期/Last Update: 2025-01-06