[1]应 龙,臧学利,李晓焱.血清β-人绒毛膜促性腺激素、视黄醇结合蛋白4在子宫内膜增生患者中的水平变化及检测意义[J].陕西医学杂志,2024,(11):1513-1516.[doi:DOI:10.3969/j.issn.1000-7377.2024.11.016]
　YING Long,ZANG Xueli,LI Xiaoyan.Changes and detection significance of serum β-human chorionic gonadotropin and retinol-binding protein 4 in patients with endometrial hyperplasia[J].,2024,(11):1513-1516.[doi:DOI:10.3969/j.issn.1000-7377.2024.11.016]
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血清β-人绒毛膜促性腺激素、视黄醇结合蛋白4在子宫内膜增生患者中的水平变化及检测意义
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《陕西医学杂志》[ISSN:1000-7377/CN:61-1281/TN]

卷:
期数:
2024年11期
页码:
1513-1516
栏目:
临床研究
出版日期:
2024-11-05

文章信息/Info

Title:
Changes and detection significance of serum β-human chorionic gonadotropin and retinol-binding protein 4 in patients with endometrial hyperplasia
作者:
应 龙; 臧学利; 李晓焱
(淮北矿工总医院妇产科,安徽 淮北 235099)
Author(s):
YING Long; ZANG Xueli; LI Xiaoyan
(Department of Obstetrics and Gynaecology,Huaibei Miners General Hospital,Huaibei 235099,China)
关键词:
子宫内膜增生;  β-人绒毛膜促性腺激素;  视黄醇结合蛋白4;  相关性;  预测价值
Keywords:
Endometrial hyperplasia;  β-human chorionic gonadotropin;  Retinol-binding protein 4;  Correlation;  Predictive value
分类号:
R 711.74
DOI:
DOI:10.3969/j.issn.1000-7377.2024.11.016
文献标志码:
A
摘要:
目的:探讨血清β-人绒毛膜促性腺激素(β-HCG)、视黄醇结合蛋白4(RBP4)在子宫内膜增生患者中的水平变化及检测意义。方法:选取105例子宫内膜增生患者为研究组,65例体检健康者为对照组。比较研究组和对照组血清β-HCG、RBP4水平。比较不同病理类型以及内膜增生程度患者血清β-HCG、RBP4水平。测量患者子宫内膜厚度,采用Pearson法分析血清β-HCG、RBP4水平与患者子宫内膜厚度的相关性。绘制受试者特征工作(ROC)曲线分析血清β-HCG、RBP4对非典型子宫内膜增生的预测价值。结果:研究组血清β-HCG、RBP4水平高于对照组(均P<0.05)。非典型子宫内膜增生患者血清β-HCG、RBP4水平高于单纯及复杂性子宫内膜增生患者(均P<0.05)。内膜增生过长患者血清β-HCG、RBP4水平高于增生及分泌期患者(均P<0.05)。血清β-HCG、RBP4水平与患者子宫内膜厚度呈正相关(均P<0.05)。血清β-HCG、RBP4单独及联合预测非典型子宫内膜增生的AUC分别为0.758、0.660、0.926,且两者联合预测的AUC高于各指标单独预测AUC(均P<0.05)。结论:子宫内膜增生患者血清RBP4、β-HCG水平升高,两者与病理类型、内膜增生程度以及子宫内膜厚度有关,联合检测对非典型子宫内膜增生的预测价值较高。
Abstract:
Objective:To explore the level changes and detection significance of serum β-human chorionic gonadotropin(β-HCG)and retinol-binding protein 4(RBP4)in patients with endometrial hyperplasia.Methods:A total of 105 patients with endometrial hyperplasia were selected as the study group,and 65 healthy individuals were included in the control group.The levels of serum β-HCG and RBP4 were compared between the study group and the control group.The levels of serum β-HCG and RBP4 were compared among patients with different pathological types and degrees of endometrial hyperplasia.The endometrial thickness of patients was measured,and the correlation between serum β-HCG and RBP4 levels and endometrial thickness was analyzed using Pearson method.The ROC curve was drawn to analyze the predictive value of serum β-HCG and RBP4 for atypical endometrial hyperplasia.Results:The levels of serum β-HCG and RBP4 in the study group were higher than those in the control group(all P<0.05).The levels of serum β-HCG and RBP4 in patients with atypical endometrial hyperplasia were higher than those in patients with simple and complex endometrial hyperplasia(all P<0.05).The levels of serum β-HCG and RBP4 in patients with excessive endometrial hyperplasia were higher than those in patients with proliferative and secretory phases(all P<0.05).The levels of serum β-HCG and RBP4 were positively correlated with the endometrial thickness of patients(all P<0.05).The AUCs of serum β-HCG and RBP4 alone and in combination for predicting atypical endometrial hyperplasia were 0.758,0.660,and 0.926 respectively,and the AUC of combined prediction was higher than that of each index alone(all P<0.05).Conclusion:The levels of serum RBP4 and β-HCG in patients with endometrial hyperplasia are increased,and they are related to pathological types,the degree of endometrial hyperplasia,and the thickness of the endometrium.The combined detection has a high predictive value for atypical endometrial hyperp-lasia.

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相似文献/References:

[1]郭 晓,郭战坤,李 静.血清胎盘蛋白-13、β-人绒毛膜促性腺激素、分泌型卷曲相关蛋白5及血清胎盘生长因子检测对妊娠期糖尿病不良妊娠结局的诊断价值[J].陕西医学杂志,2023,52(8):1085.[doi:DOI:10.3969/j.issn.1000-7377.2023.08.033]

备注/Memo

备注/Memo:
基金项目:安徽省重点研究与开发计划项目(2022E07020059)
更新日期/Last Update: 2024-11-04