[1]张庆子,朱 博,姚 玲,等.脑微出血与脑出血患者卒中复发危险因素相关性研究[J].陕西医学杂志,2024,(10):1352-1355,1361.[doi:DOI:10.3969/j.issn.1000-7377.2024.10.012]
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脑微出血与脑出血患者卒中复发危险因素相关性研究
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《陕西医学杂志》[ISSN:1000-7377/CN:61-1281/TN]

卷:
期数:
2024年10期
页码:
1352-1355,1361
栏目:
临床研究
出版日期:
2024-10-05

文章信息/Info

作者:
张庆子1朱 博2姚 玲1陈婉儿3苗 建1魏雅馨2牛金慧12马 蕊2郑欣悦2王少君1
(1.延安大学咸阳医院神经内科,陕西 咸阳,712000; 2.延安大学医学院,陕西 延安,716000; 3.咸阳市中心医院神经内科,陕西 咸阳,712000)
关键词:
脑出血 脑微出血 卒中复发 死亡风险 二级预防
分类号:
R 743
DOI:
DOI:10.3969/j.issn.1000-7377.2024.10.012
文献标志码:
A
摘要:
目的:探究脑微出血(CMBs)等危险因素在脑出血后生存患者卒中复发及死亡风险的临床意义及应用价值。方法:选择收治的首次原发性急性脑出血患者186例,采用磁共振磁敏加权成像检出CMBs,将入组患者按照CMBs负荷及部位分布进行分组。出院后进行电话随访,随访期为12个月,随访终止事件为卒中复发(缺血性和出血性)和全因死亡。采用Cox比例风险模型评价CMBs存在、负荷以及部位分布等因素对脑出血后生存患者卒中复发(缺血性及出血性)及死亡风险的影响。结果:共统计分析患者为171例,其中CMBs组121例,无CMBs组50例,CMBs检出率约为70.76%。多因素Logistic回归分析结果显示年龄和高血压病史是影响CMBs发生的危险因素(均P<0.05)。入组患者共发生终点事件16例(9.36%): 其中发生缺血性卒中5例( 2.92%),复发脑出血5 例( 2.92%),全因死亡6例( 3.51%)。多因素Cox回归分析结果显示既往脑梗死病史(RR=3.160,95%CI:1.148~8.698,P=0.026)是影响脑出血患者发生卒中复发或死亡等复合终点事件的独立危险因素,而CMBs的存在、负荷以及部位分布未发现统计学差异(均P>0.05)。结论:CMBs在脑出血患者中有很高的患病率,年龄、高血压病史是脑出血患者发生CMBs的危险因素; 合并既往脑梗死病史是脑出血患者发生卒中复发或死亡等复合终点事件的独立危险因素; CMBs的存在、负荷及部位分布与脑出血患者卒中复发及死亡风险无统计学差异。

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备注/Memo

备注/Memo:
基金项目:陕西省重点研发计划项目(2024SF-YBXM-039)
更新日期/Last Update: 2024-10-08