[1]刘 婕,陈抒鹏,章美玲,等.自然杀伤细胞家族2成员D受体-配体轴在血液瘤中的作用研究进展[J].陕西医学杂志,2024,(9):1286-1289,封3.[doi:DOI:10.3969/j.issn.1000-7377.2024.09.029]
 LIU Jie,CHEN Shupeng,ZHANG Meiling,et al.Research progress on role of NKG2D receptor-ligand axis in hematomas[J].,2024,(9):1286-1289,封3.[doi:DOI:10.3969/j.issn.1000-7377.2024.09.029]
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自然杀伤细胞家族2成员D受体-配体轴在血液瘤中的作用研究进展
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《陕西医学杂志》[ISSN:1000-7377/CN:61-1281/TN]

卷:
期数:
2024年9期
页码:
1286-1289,封3
栏目:
综 述
出版日期:
2024-09-05

文章信息/Info

Title:
Research progress on role of NKG2D receptor-ligand axis in hematomas
作者:
刘 婕1陈抒鹏1章美玲1曾英坚2
(1.江西中医药大学临床医学院,江西 南昌 330004; 2.江西中医药大学附属医院,江西 南昌 330006)
Author(s):
LIU JieCHEN ShupengZHANG MeilingWU ZhenhuiZENG Yingjian
(School of Clinical Medicine,Jiangxi University of Chinese Medicine,Nanchang 330004,China)
关键词:
血液瘤 自然杀伤2组成员D受体 自然杀伤2组成员D配体 免疫逃逸 治疗靶点 靶向药物
Keywords:
Hematoma Natural killer cell family 2 member D receptor Natural killer cell family 2 member D ligands Immune escape Therapeutic targets Targeted drugs
分类号:
R 733
DOI:
DOI:10.3969/j.issn.1000-7377.2024.09.029
文献标志码:
A
摘要:
自然杀伤细胞家族2成员D(NKG2D)受体通过表达在自然杀伤(NK)细胞和细胞毒性T淋巴(CTLs)细胞上激活这些免疫细胞对抗肿瘤。肿瘤细胞通过降低自然杀伤细胞家族2成员D配体(NKG2DLs)的表达来逃避免疫系统的监视,从而促进肿瘤的免疫逃逸。最新的研究揭示了NKG2D受体-配体轴在血液瘤的发展、免疫监视和治疗中的关键作用,尤其是在阐明免疫逃逸机制和开发新的治疗策略方面显示出巨大潜力。现从NKG2D受体-配体轴在血液瘤发病机制、免疫监测及治疗中的作用进行阐述,在加深对血液瘤病理机制理解的同时,为提升治疗效果开辟了新的策略。
Abstract:
The natural killer cell family 2 member D(NKG2D)receptor activate immune cells to fight against tumors by being expressed on natural killer(NK)cells and cytotoxic T lymphocytes(CTLs).Tumor cells evade immune system surveillance by reducing the expression of natural killer cell family 2 member D ligands(NKG2DLs),thereby promoting tumor immune escape.The latest research has revealed the crucial role of the NKG2D receptor-ligand axis in the development,immune monitoring,and treatment of hematomas,particularly in elucidating immune escape mechanisms and developing new treatment strategies,demonstrating enormous potential.This article reviews the role of NKG2D receptor-ligand axis in the pathogenesis,immune monitoring and treatment of hematomas,which will deepen the understanding of the pathological mechanism of hematomas and open up new strategies for improving the therapeutic effect.

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备注/Memo

备注/Memo:
基金项目:国家自然科学基金资助项目(82260914); 江西省自然科学基金资助面上项目(20192BAB205100); 江西省中医药管理局临床研究基地(第二批)建设项目(赣中医药科教字[2021]3号); 江西省中医药管理局中医优势病种培育项目(赣财社指[2022]56号)
更新日期/Last Update: 2024-09-04