[1]刘冬梅,盖增鑫,王志敏,等.促性腺激素释放激素拮抗剂方案和激动剂长方案在卵巢储备功能正常不孕患者中的应用效果比较[J].陕西医学杂志,2024,(9):1232-1235.[doi:DOI:10.3969/j.issn.1000-7377.2024.09.017]
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促性腺激素释放激素拮抗剂方案和激动剂长方案在卵巢储备功能正常不孕患者中的应用效果比较
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《陕西医学杂志》[ISSN:1000-7377/CN:61-1281/TN]

卷:
期数:
2024年9期
页码:
1232-1235
栏目:
药物与临床
出版日期:
2024-09-05

文章信息/Info

作者:
刘冬梅1盖增鑫1王志敏2武传叶1
(1.临沂市妇幼保健院生殖医学科,山东 临沂 276016; 2.山东省立第三医院生殖医学科,山东 济南 250031)
关键词:
不孕 促性腺激素释放激素拮抗剂 促性腺激素释放激素激动剂 卵巢储备功能 体外授精-胚胎移植
分类号:
R 271.14
DOI:
DOI:10.3969/j.issn.1000-7377.2024.09.017
文献标志码:
A
摘要:
目的:比较促性腺激素释放激素(GnRH)拮抗剂方案和GnRH激动剂长方案在卵巢储备功能正常的不孕患者中的应用效果。方法:选取进行首次体外授精-胚胎移植的卵巢储备功能正常的不孕患者423例,根据治疗方案不同进行分组,其中234例采取GnRH拮抗剂方案(GnRH拮抗组),189例采取GnRH激动剂长方案(GnRH激动组),比较两组应用效果。结果:GnRH拮抗组促性腺激素(Gn)总剂量、应用时间、取卵数及可利用胚胎数低于GnRH激动组(均P<0.05)。两组卵胞浆内单精子注射(ICSI)率和正常受精率比较无统计学差异(均P>0.05)。两组妊娠结局比较无统计学差异(P>0.05)。结论:GnRH拮抗剂方案和GnRH激动剂长方案在卵巢储备功能正常不孕患者中具有同样理想的应用效果,可根据患者临床需求进行选择。

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备注/Memo

备注/Memo:
基金项目:山东省重点研发计划项目(2019GSF127132)
更新日期/Last Update: 2024-09-04