[1]努尔比亚·热西提,崔迎雪,贺 曼,等.SERPINC1和MTHFR基因多态性与新疆地区恶性肿瘤患者静脉血栓栓塞症相关性研究[J].陕西医学杂志,2024,(8):1051-1054,1059.[doi:DOI:10.3969/j.issn.1000-7377.2024.08.009]
　REXITI Nuerbiya,CUI Yingxue,HE Man,et al.Correlation between SERPINC1 and MTHFR gene polymorphisms and venous thromboembolism in patients with malignant tumors in Xinjiang[J].,2024,(8):1051-1054,1059.[doi:DOI:10.3969/j.issn.1000-7377.2024.08.009]
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SERPINC1和MTHFR基因多态性与新疆地区恶性肿瘤患者静脉血栓栓塞症相关性研究
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《陕西医学杂志》[ISSN:1000-7377/CN:61-1281/TN]

卷:
期数:
2024年8期
页码:
1051-1054,1059
栏目:
临床研究
出版日期:
2024-08-05

文章信息/Info

Title:
Correlation between SERPINC1 and MTHFR gene polymorphisms and venous thromboembolism in patients with malignant tumors in Xinjiang
作者:
努尔比亚·热西提; 崔迎雪; 贺 曼; 朱子辉; 侯雪萍; 王玉莹; 蒋威华
(新疆医科大学第三临床医学院,新疆 乌鲁木齐 830011)
Author(s):
REXITI Nuerbiya; CUI Yingxue; HE Man; ZHU Zihui; HOU Xueping; WANG Yuying; JIANG Weihua
(Third Clinical Medical College of Xinjiang Medical University,Urumqi 830011,China)
关键词:
静脉血栓栓塞症;  MTHFR基因;  SERPINC1基因;  恶性肿瘤;  相关性;  新疆地区
Keywords:
Venous thromboembolism;  MTHFR gene;  SERPINC1 gene;  Malignant tumor;  Correlation;  Xinjiang
分类号:
R 543.6
DOI:
DOI:10.3969/j.issn.1000-7377.2024.08.009
文献标志码:
A
摘要:
目的:探讨SERPINC1和亚甲基四氢叶酸还原酶(MTHFR)基因多态性与新疆地区恶性肿瘤患者静脉血栓栓塞症(VTE)的相关性。方法:选取恶性肿瘤患者227例,根据是否发生VTE将患者分为VTE组(47例)和对照组(180例)。比较两组患者一般资料。观察并比较两组患者SERPINC1基因rs2227589位点和MTHFR基因rs1801133位点的基因多态性,分析与VTE的相关性。结果:VTE组有糖尿病史患者占比高于对照组(P<0.05)。在两组患者SERPINC1 T/C基因型分布频率中,C等位基因频率高于T等位基因频率。在两组患者MTHFR A/G基因分布频率中,G等位基因频率高于A等位基因频率。MTHFR基因A/G基因型和SERPINC1基因T/C基因型的理论例数与实际例数比较差异无统计学意义(均P>0.05),符合Hardy-Weinberg遗传平衡。VTE组和对照组SERPINC1基因rs2227589位点基因型及T基因频率比较差异无统计学意义(均P>0.05)。VTE组和对照组MTHFR基因rs1801133位点基因型比较差异有统计学意义,且VTE组A等位基因频率高于对照组(均P<0.05)。结论:新疆地区恶性肿瘤患者MTHFR基因rs1801133位点基因多态性与VTE有关,等位基因A携带者VTE发生风险较高,且糖尿病史也与VTE有关。
Abstract:
Objective:To investigate the correlation between SERPINC1 and 5,10-methylenetetrahydrofolate reductase(MTHFR)gene polymorphisms and venous thromboembolism(VTE)in patients with malignant tumors in Xinjiang.Methods:A total of 227 patients with malignant tumors were selected,and the patients were divided into VTE group(47 cases)and control group(180 cases)according to whether VTE occurred.The general data of the two groups were compared.The polymorphisms of rs2227589 in SERPINC1 gene and rs1801133 in MTHFR gene were observed and compared between the two groups,and the correlation with VTE was analyzed.Results:The proportion of patients with diabetes mellitus in the VTE group was higher than that in the control group(P<0.05).Among the distribution frequencies of SERPINC1 T/C genotype in the two groups,the frequency of C allele was higher than that of T allele.Among the distribution frequencies of MTHFR A/G genes in the two groups,the frequency of G allele was higher than that of A allele.There was no significant difference between the theoretical and actual cases of A/G genotype of MTHFR gene and T/C genotype of SERPINC1 gene(all P>0.05),which was consistent with Hardy-Weinberg genetic balance.There were no significant differences in genotype of rs2227589 in SERPINC1 gene and T gene frequencies between VTE group and control group(all P>0.05).There was a statistically significant difference in genotype of rs1801133 in MTHFR gene between VTE group and control group,and the frequency of allele A in VTE group was higher than that in control group(all P<0.05).Conclusion:The polymorphism of rs1801133 in MTHFR gene is associated with VTE in malignant tumor patients in Xinjiang.Allele A carriers have a higher risk of VTE,and the history of diabetes is also associated with VTE.

参考文献/References:

[1] 马军,秦叔逵,吴一龙,等.肿瘤相关静脉血栓栓塞症预防与治疗指南(2019版)[J].中国肿瘤临床,2019,46(13):653-660.
[2] CROUS-BOU M,HARRINGTON L,KABRHEL C.Environmental and genetic risk factors associated with venous thromboembolism[J].Seminars in Thrombosis & Hemostasis,2016,42(8):808-820.
[3] BAKHSH E.The benefits and imperative of venous thromboembolism risk screening for hospitalized patients:A systematic review[J].Journal of Clinical Medicine,2023,12(22):709-712.
[4] 熊明秀,张静.肿瘤驱动基因与静脉血栓栓塞关系研究进展[J].实用心脑肺血管病杂志,2024,32(3):123-127.
[5] 王学智,张斌,赖全友,等.肝癌切除术后检测D-二聚体及纤维蛋白原降解产物变化对深静脉血栓形成预防意义研究[J].陕西医学杂志,2018,47(8):980-983.
[6] DANIELE P,MARIA V C,SILVIA M,et al.A comprehensive review of risk factors for venous thromboembolism:From epidemiology to pathophysiology[J].International Journal of Molecular Sciences,2023,24(4):169-173.
[7] 黄玲,傅德杰,邓姝.全膝关节置换术后深静脉血栓形成机制、危险因素及预防研究进展[J].陕西医学杂志,2024,53(3):428-432.
[8] LU Z,WANG F,LIANG M.SerpinC1/antithrombin Ⅲ in kidney-related diseases[J].Clinical Science(Lond),2017,131(9):823-831.
[9] XU D,WU J,DONG L,et al.Serpinc1 acts as a tumor suppressor in hepatocellular carcinoma through inducing apoptosis and blocking macrophage polarization in an ubiquitin-proteasome manner[J].Frontiers in Oncology,2021,11:738607.
[10] ZHOU K,ZHANG J,ZHENG Z R,et al.Diagnostic and prognostic value of TAT,PIC,TM,and t-PAIC in malignant tumor patients with venous thrombosis[J].Clinical and Applied Thrombosis/Hemostasis,2020,26:1076029620971041.
[11] KIM S,LEE W J,MOON J,et al.Utility of the SERPINC1 gene test in ischemic stroke patients with antithrombin deficiency[J].Front Neurol,2022,13:841934.
[12] WANG Y W,HUO L L,HUANG Z Y,et al.Research progress on MTHFR C677T and A1298C gene polymorphisms and gastrointestinal tumors[J].Journal of Biosciences and Medicines,2023,11(6):148-160.
[13] PETRONE I,BERNARDO P S,DOS-SANTOS E C,et al.MTHFR C677T and A1298C polymorphisms in breast cancer,gliomas and gastric cancer:A review[J].Genes(Basel),2021,12(4):587-590.
[14] SAMII A,ASLANI S,IMANI D,et al.MTHFR gene polymorphisms and susceptibility to myocardial infarction:Evidence from meta-analysis and trial sequential analysis[J].IJC Heart & Vasculature,2023,49:101293.
[15] 余晴,方宝枝,吕明恩.遗传性易栓症基因诊断的研究进展[J].实用临床医药杂志,2022,26(21):140-143.
[16] 杨旭虎,徐伍,刘建成,等.易栓症分子遗传学研究进展[J].陕西医学杂志,2023,52(10):1442-1445.
[17] 唐仪,骆珍玉,方主亭,等.MTHFR基因多态性与深静脉血栓形成及血瘀积分的相关性分析[J].中西医结合心脑血管病杂志,2019,17(12):1775-1780.
[18] 潘秀锋,李付广,李敏婷,等.MTHFR(C677T)基因多态性和同型半胱氨酸与急性脑梗死患者静脉血栓形成的相关性研究[J].检验医学与临床,2023,20(23):3480-3484.
[19] LUPI-HERRERA E,SOTO-LÓPEZ M E,LUGO-DIMAS A J,et al.Polymorphisms C677T and A1298C of MTHFR gene:Homocysteine levels and prothrombotic biomarkers in coronary and pulmonary thromboembolic disease[J].Clinical and Applied Thrombosis/Hemostasis,2019,25:1076029618780344.
[20] OSADNIK T,PAWLAS N,LEJAWA M,et al.Genetic and environmental factors associated with homocysteine concentrations in a population of healthy young adults.Analysis of the MAGNETIC study[J].Nutrition Metabolism and Cardiovascular Diseases,2020,30(6):939-947.
[21] ZENG J,ZENG Q.Correlations between methylenetetrahydrofolate reductase gene polymorphisms and venous thromboembolism:A meta-analysis of 99 genetic association studies[J].European Journal of Preventive Cardiology,2019,26(2):120-134.
[22] GAO M,FENG N,ZHANG M,et al.Meta analysis of the relationship between methylenetetrahydrofolate reductase C677T and A1298C polymorphism and venous thromboembolism in the Caucasian and Asian[J].Bioscience Reports,2020,40(7):202-206.
[23] ZHANG P,GAO X,ZHANG Y,et al.Association between MTHFR C677T polymorphism and venous thromboembolism risk in the Chinese population:A meta-analysis of 24 case-controlled studies[J].Angiology,2015,66(5):422-432.
[24] KEY N S,KHORANA A A,KUDERER N M,et al.Venous thromboembolism prophylaxis and treatment in patients with cancer:ASCO clinical practice guideline update[J].Clinical Oncology,2020,38(5):496-520.
[25] 周伟君,霍少川,蔡迎峰,等.益气活血通络汤联合阿司匹林预防人工髋关节置换术后深静脉血栓形成临床研究[J].陕西中医,2020,41(8):1070-1073.
[26] 蒋守涛,吴永刚,叶少强,等.通阳宽胸方联合PCI治疗急性心肌梗死疗效及对患者血管内皮功能的影响[J].陕西中医,2020,41(7):871-874.

备注/Memo

备注/Memo:
基金项目:国家自然科学基金资助项目(82360468)
更新日期/Last Update: 2024-08-08