[1]孟 洁,康亚丽,任更朴,等.术前外周血纤维蛋白原与前白蛋白比值、C反应蛋白与前白蛋白比值、C反应蛋白与白蛋白比值与胃癌患者预后关系研究[J].陕西医学杂志,2024,(7):987-990.[doi:DOI:10.3969/j.issn.1000-7377.2024.07.027]
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术前外周血纤维蛋白原与前白蛋白比值、C反应蛋白与前白蛋白比值、C反应蛋白与白蛋白比值与胃癌患者预后关系研究
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《陕西医学杂志》[ISSN:1000-7377/CN:61-1281/TN]

卷:
期数:
2024年7期
页码:
987-990
栏目:
临床检验
出版日期:
2024-07-05

文章信息/Info

作者:
孟 洁; 康亚丽; 任更朴; 张丽媛; 于艳艳
(聊城市第二人民医院检验科,山东 聊城 252600)
关键词:
胃癌;  纤维蛋白原与前白蛋白比值;  C反应蛋白与前白蛋白比值;  C反应蛋白/白蛋白比值;  预后;  临床病理特征
分类号:
R 735.2
DOI:
DOI:10.3969/j.issn.1000-7377.2024.07.027
文献标志码:
A
摘要:
目的: 探究术前外周血纤维蛋白原与前白蛋白比值(FPR)、C反应蛋白与前白蛋白比值(CRP/PA)、C反应蛋白/白蛋白比值(CRP/Alb)与胃癌患者预后的关系。方法:回顾性分析行根治性手术的104例胃癌患者临床资料,收集患者实验组指标并计算FPR、CRP/PA、CRP/ALB值,根据随访1年后患者生存情况将患者分为生存组(92例)和死亡组(12例),采用受试者工作特征(ROC)曲线分析三者对胃癌预后的预测价值。以最佳界值为标准,将患者分为高FPR(CRP/PA、CRP/ALB)组和低FPR(CRP/PA、CRP/ALB)组,分析两组患者FPR、CRP/PA、CRP/ALB水平与临床病理特征的关系,Kaplan-Meier生存曲线、Cox比例风险模型评估外周血FPR、CRP/PA、CRP/ALB在预测胃癌患者预后的意义。结果:FPR、CRP/PA、CRP/ALB的ROC曲线显示曲线下面积(AUC)为0.716、0.747、0.661,当FPR、CRP/PA为15.88、0.052时,AUC最大,敏感度为58.33%、98.52%,特异度为85.87%、57.61%; FPR水平与术前贫血、肿瘤直径、分化程度、TNM分期、淋巴转移有关,CRP/PA水平与术前贫血、肿瘤直径、TNM分期、淋巴转移有关(均P<0.05); 低FPR、CRP/PA组患者生存率高于高FPR、CRP/PA组(均P<0.05); 分化程度、TNM分期、淋巴转移、FPR、CRP/PA、CRP/ALB是影响胃癌患者预后的独立危险因素(均P<0.05)。结论:术前外周血FPR、CRP/PA、CRP/ALB比值可评估胃癌患者预后情况,可为预测胃癌患者长期预后提供临床依据。

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备注/Memo

备注/Memo:
基金项目:山东省医药卫生科技发展项目(202211000916)
更新日期/Last Update: 2024-07-04