[1]王蓓明,冯增利,刘 艳,等.腹主动脉瘤患者血清转胶蛋白、基质金属蛋白酶9和核因子-κB p65水平检测及意义[J].陕西医学杂志,2024,(6):838-841,847.[doi:DOI:10.3969/j.issn.1000-7377.2024.06.025]
　WANG Beiming,FENG Zengli,LIU Yan,et al.Detection and significance of serum TAGLN,MMP-9 and NF-κB p65 in patients with abdominal aortic aneurysm[J].,2024,(6):838-841,847.[doi:DOI:10.3969/j.issn.1000-7377.2024.06.025]
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腹主动脉瘤患者血清转胶蛋白、基质金属蛋白酶9和核因子-κB p65水平检测及意义
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《陕西医学杂志》[ISSN:1000-7377/CN:61-1281/TN]

卷:
期数:
2024年6期
页码:
838-841,847
栏目:
临床检验
出版日期:
2024-06-05

文章信息/Info

Title:
Detection and significance of serum TAGLN,MMP-9 and NF-κB p65 in patients with abdominal aortic aneurysm
作者:
王蓓明; 冯增利; 刘 艳; 贾凯宁; 张首用; 王海刚
(华北石油管理局总医院,河北 任丘 062552)
Author(s):
WANG Beiming; FENG Zengli; LIU Yan; JIA Kaining; ZHANG Shouyong; WANG Haigang
(General Hospital of North China Petroleum Administration Bureau,Renqiu 062552,China)
关键词:
腹主动脉瘤;  转胶蛋白;  基质金属蛋白酶9;  核因子-κB p65;  诊断价值
Keywords:
Abdominal aortic aneurysm;  Transgelin;  Matrix metalloproteinase 9;  Nuclear factor-κB;  Diagnostic value
分类号:
R 543.16
DOI:
DOI:10.3969/j.issn.1000-7377.2024.06.025
文献标志码:
A
摘要:
目的:检测腹主动脉瘤(AAA)患者血清转胶蛋白(TAGLN)、基质金属蛋白酶9(MMP-9)和核因子-κB(NF-κB)p65水平变化,探讨其临床意义。方法:通过酶联免疫吸附法检测肾下AAA患者80例(AAA组)及体检健康者50例(健康组)血清TAGLN、MMP-9和NF-κB p65水平并进行比较。分析三者间的相关性,分析三者对AAA的诊断价值。结果:健康组血清TAGLN水平高于AAA组,MMP-9和NF-κB p65水平低于AAA组(均P<0.05)。血清TAGLN与MMP-9和NF-κB p65呈负相关(r=-0.196、-0.364,均P<0.05),MMP-9与NF-κB p65呈正相关(r=0.213,P=0.015)。TAGLN、MMP-9和NF-κB p65联合诊断AAA的曲线下面积(AUC)高于任意单独指标,而敏感度和特异度不低于任意单独指标(均P<0.05)。结论:AAA患者血清TAGLN水平升高,MMP-9和NF-κB p65水平降低,三者联合检测对AAA的诊断具有较高价值。
Abstract:
Objective:To detect the changes of serum transgelin(TAGLN),matrix metalloproteinase 9(MMP-9)and nuclear factor kappaB(NF-κB)p65 levels in patients with abdominal aortic aneurysm(AAA),and to explore their clinical significance.Methods:The serum levels of TAGLN,MMP-9 and NF-κB p65 were detected by ELISA in 80 AAA patients(AAA group)and 50 healthy subjects(healthy group).The correlation among the three markers,and the diagnostic value of the three markers for AAA were analyzed.Results: The serum TAGLN level in the healthy group was higher than that in the AAA group,and the levels of MMP-9 and NF-κB p65 were lower than those in the AAA group(allP<0.05).Serum TAGLN was negatively correlated with MMP-9 and NF-κB p65(r=-0.196,-0.364,all P<0.05),and MMP-9 was positively correlated with NF-κB p65(r=0.213,P=0.015).The AUC of TAGLN,MMP-9 and NF-κB p65 combined in the diagnosis of AAA was higher than that of any single indicator,while the sensitivity and specificity were not lower than those of any single indicator(all P<0.05).Conclusion:The serum TAGLN level is increased,while MMP-9 and NF-κB p65 levels are decreased in AAA patients.The combined detection of the three markers has a high value in the diagnosis of AAA.

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[1]田 原,陈伟志,牛玉军.腹主动脉瘤患者D-二聚体水平及其与腹主动脉瘤最大直径、腔内血栓厚度相关性分析[J].陕西医学杂志,2022,51(3):325.[doi:DOI:10.3969/j.issn.1000-7377.2022.03.014]
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备注/Memo

备注/Memo:
基金项目:河北省卫生健康委员会医学科学研究课题(20210911)
更新日期/Last Update: 2024-06-05