[1]吴 婉,姜 苗,许婷媛,等.老年稳定期慢性阻塞性肺疾病患者血清C-反应蛋白和白细胞介素-6表达与1年内频繁发作关系研究[J].陕西医学杂志,2024,(3):352-356.[doi:DOI:10.3969/j.issn.1000-7377.2024.03.014]
　WU Wan,JIANG Miao,XU Tingyuan,et al.Relationship between serum levels of C-reactive protein,interleukin-6 and frequent exacerbations within one year in elderly patients with stable chronic obstructive pulmonary disease[J].,2024,(3):352-356.[doi:DOI:10.3969/j.issn.1000-7377.2024.03.014]
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老年稳定期慢性阻塞性肺疾病患者血清C-反应蛋白和白细胞介素-6表达与1年内频繁发作关系研究
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《陕西医学杂志》[ISSN:1000-7377/CN:61-1281/TN]

卷:
期数:
2024年3期
页码:
352-356
栏目:
临床研究
出版日期:
2024-03-05

文章信息/Info

Title:
Relationship between serum levels of C-reactive protein,interleukin-6 and frequent exacerbations within one year in elderly patients with stable chronic obstructive pulmonary disease
作者:
吴 婉1; 姜 苗2; 许婷媛1; 徐贤华1
(1.西部战区总医院干部病房,四川 成都 610083; 2.西部战区总医院干部一科,四川 成都 610083)
Author(s):
WU Wan; JIANG Miao; XU Tingyuan; XU Xianhua
(Cadre Ward,General Hospital of Western Theater Command,Chengdu 610083,China)
关键词:
慢性阻塞性肺疾病;  老年人;  血清C-反应蛋白;  白细胞介素-6;  频繁发作;  预测价值
Keywords:
Chronic obstructive pulmonary disease;  Elderly;  Serum C-reactive protein;  Interleukin-6;  Frequent exacerbations;  Predictive value
分类号:
R 563.9
DOI:
DOI:10.3969/j.issn.1000-7377.2024.03.014
文献标志码:
A
摘要:
目的:探讨老年稳定期慢性阻塞性肺疾病患者血清C-反应蛋白(CRP)、白细胞介素-6(IL-6)表达与1年内频繁发作的关系。方法:选取老年稳定期慢性阻塞性肺疾病患者123例为研究对象,进行为期1年的有效随访,依据随访期间患者发作次数分为频繁发作组(70例,发作次数≥3次)与非频繁发作组(53例,发作次数≤2次)。比较两组临床资料与血清CRP、IL-6表达情况。分析血清CRP、IL-6表达与老年稳定期慢性阻塞性肺疾病患者1年内频繁发作的关系,及其对1年内频繁发作情况的预测价值。结果:123例患者均完成有效随访,其中频繁发作70例,非频繁发作患者53例。与非频繁发作组比较,频繁发作组血清CRP、IL-6表达均较高,平均发作次数较多(均P<0.05)。多元Logistic回归分析结果显示,血清CRP、IL-6高表达可能是导致老年稳定期慢性阻塞性肺疾病患者1年内频繁发作的危险因素(均P<0.05)。受试者工作特征(ROC)曲线分析显示,血清CRP、IL-6表达预测老年稳定期慢性阻塞性肺疾病患者1年内频繁发作情况的曲线下面积(AUC)均>0.90,尤其两者联合预测的AUC最大(均P<0.05)。血清CRP、IL-6表达与老年稳定期慢性阻塞性肺疾病患者1年内平均发作次数呈正相关(均P<0.05)。结论:血清CRP、IL-6高表达是导致老年稳定期慢性阻塞性肺疾病患者1年内频繁发作的因素,对1年内发作状态具有较高的预测价值。
Abstract:
Objective:To investigate the relationship between serum levels of C-reactive protein(CRP),interleukin-6(IL-6)and frequent exacerbations within 1 year in elderly patients with stable chronic obstructive pulmonary disease.Methods:A total of 123 elderly patients with stable chronic obstructive pulmonary disease were enrolled and followed up for 1 year.According to the number of exacerbations during the follow-up period,the patients were divided into frequent exacerbation group(70 cases,the number of attacks ≥3)and non-frequent exacerbation group(53 cases,the number of attacks ≤2).The clinical data and the expressions of serum CRP and IL-6 were compared between the two groups.The relationship between serum levels of CRP,IL-6 and frequent exacerbations within 1 year in elderly patients with stable chronic obstructive pulmonary disease,and their predictive value for frequent exacerbations within 1 year were analyzed.Results:All the 123 patients completed the effective follow-up,including 70 patients with frequent exacerbation and 53 patients with non-frequent exacerbation.Compared with the non-frequent exacerbation group,the serum levels of CRP and IL-6 in the frequent exacerbation group were higher,and the average number of exacerbations was more(all P<0.05).Multiple Logistic regression analysis showed that high expressions of serum CRP and IL-6 may be the risk factors for frequent exacerbations in elderly patients with stable chronic obstructive pulmonary disease within 1 year(all P<0.05).ROC curve analysis showed that the AUC of serum CRP and IL-6 levels in predicting frequent exacerbations within 1 year in elderly patients with stable chronic obstructive pulmonary disease was >0.90,especially the AUC of the combination of CRP and IL-6 was the largest(all P<0.05).The serum levels of CRP and IL-6 were positively correlated with the average number of exacerbations within 1 year in elderly patients with stable chronic obstructive pulmonary disease(all P<0.05).Conclusion:High levels of serum CRP and IL-6 are risk factors for frequent exacerbations in elderly patients with stable chronic obstructive pulmonary disease within 1 year,and they have high predictive value for exacerbation status within 1 year.

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备注/Memo

备注/Memo:
基金项目:四川省卫生健康委员会科研课题(18PJ511)
更新日期/Last Update: 2024-03-05