[1]施嘉华,陈真珍,黄龙坚,等.铁死亡在脑缺血再灌注中的作用研究进展[J].陕西医学杂志,2024,(1):132-135.[doi:DOI:10.3969/j.issn.1000-7377.2024.01.029]
 SHI Jiahua,CHEN Zhenzhen,HUANG Longjian,et al.Research progress on ferroptosis in cerebral ischemia-reperfusion injuries[J].,2024,(1):132-135.[doi:DOI:10.3969/j.issn.1000-7377.2024.01.029]
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铁死亡在脑缺血再灌注中的作用研究进展
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《陕西医学杂志》[ISSN:1000-7377/CN:61-1281/TN]

卷:
期数:
2024年1期
页码:
132-135
栏目:
综 述
出版日期:
2024-01-31

文章信息/Info

Title:
Research progress on ferroptosis in cerebral ischemia-reperfusion injuries
作者:
施嘉华1陈真珍1黄龙坚2王凯华3
(1.广西中医药大学,广西 南宁 530200; 2.右江民族医学院,广西 南宁533000; 3.广西中医药大学附属国际壮医医院,广西 南宁 530201)
Author(s):
SHI JiahuaCHEN ZhenzhenHUANG LongjianWANG Kaihua
(Guangxi University of Chinese Medicine,Nanning 530200,China)
关键词:
铁死亡 缺血性脑卒中 细胞通路 铁代谢 脂质过氧化
Keywords:
Ferroptosis Cerebral ischemia-reperfusion injury Cell pathway Iron metabolism Lipid peroxidation
分类号:
R 743.3
DOI:
DOI:10.3969/j.issn.1000-7377.2024.01.029
文献标志码:
A
摘要:
铁死亡是依赖于铁的,由脂质过氧化和活性氧大量积累而引起的受到调节的细胞死亡形式,研究表明铁死亡与脑缺血再灌注(CIRI)的进展和预后密切相关。可以靶向作用于CIRI的细胞铁死亡的环节主要是铁代谢和消耗脂质过氧化物。目前关于铁死亡的调控机制如System Xc-/GPX4,FSP1/CoQ10,DHODH/CoQ10,GCH1/BH4等已有许多研究,亦可以从中找出许多治疗各种疾病的可防御靶点。本文通过综述这些铁死亡的关键环节、细胞通路以及在缓解CIRI损伤方面的应用,以为CIRI的后续研究提供新的作用靶点和思路。
Abstract:
Ferroptosis is an iron-dependent,regulated form of cell death caused by lipid peroxidation and massive accumulation of reactive oxygen species.Numbers of studies showed that ferroptosis is intimately related to the progression and prognosis of cerebral ischemia-reperfusion injuries(CIRI).For now,the targets of ferroptosis in CIRI are still iron metabolism and consumption of lipid peroxides.At present,there have been massive studies on the regulatory mechanism of ferroptosis,such as System Xc-/GPX4,FSP1/CoQ10,DHODH/CoQ10,and GCH1/BH4,from which we can also find out lots of targets for clinical treatment.This article is going to provide some new targets and ideas for subsequent researches through reviewing the key components of ferroptosis,pathways and the applications in mitigating CIRI damage.

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备注/Memo

备注/Memo:
基金项目:国家自然科学基金资助项目(82360870); 广西中医药大学校级科研项目(2021MS011); 广西壮族自治区中医药管理局自筹经费科研课题(GXZYZ20210103); 广西中医药大学第二批“岐黄工程”高层次人才团队培育项目(2021008); 广西壮族自治区南宁市良庆区科技基地专项课题(202211); 广西壮医火路病临床研究中心广西中医脑病重点学科建设项目(GZXK-Z-20-14)
更新日期/Last Update: 2024-01-05