[1]刘 容,林 颖,崔小平,等.神经精神性系统性红斑狼疮患者血清S100A8/A9、神经丝轻链水平检测及临床意义[J].陕西医学杂志,2023,52(12):1735-1739.[doi:DOI:10.3969/j.issn.1000-7377.2023.12.024]
　LIU Rong,LIN Ying,CUI Xiaoping,et al.Detection and significance of serum S100A8/A9 and neurofilament light chain in patients with neuropsychiatric systemic lupus erythematosus[J].,2023,52(12):1735-1739.[doi:DOI:10.3969/j.issn.1000-7377.2023.12.024]
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神经精神性系统性红斑狼疮患者血清S100A8/A9、神经丝轻链水平检测及临床意义
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《陕西医学杂志》[ISSN:1000-7377/CN:61-1281/TN]

卷:
52
期数:
2023年12期
页码:
1735-1739
栏目:
临床检验
出版日期:
2023-12-05

文章信息/Info

Title:
Detection and significance of serum S100A8/A9 and neurofilament light chain in patients with neuropsychiatric systemic lupus erythematosus
作者:
刘 容; 林 颖; 崔小平; 黎上琳
(重庆大学附属黔江医院,重庆 409000)
Author(s):
LIU Rong; LIN Ying; CUI Xiaoping; LI Shanglin
(Qianjiang Hospital Affiliated to Chongqing University,Chongqing 409000,China)
关键词:
神经精神性系统性红斑狼疮;  S100A8/A9;  神经丝轻链;  疾病严重程度;  影响因素;  诊断价值
Keywords:
Neuropsychiatric systemic lupus erythematosus;  S100A8/A9;  Neurofilament light chain;  Severity of illness;  Influencing factors;  Diagnostic value
分类号:
R 593.24
DOI:
DOI:10.3969/j.issn.1000-7377.2023.12.024
文献标志码:
A
摘要:
目的:探讨神经精神性系统性红斑狼疮(NPSLE)患者血清S100A8/A9、神经丝轻链(NfL)水平检测及临床意义。方法:选取系统性红斑狼疮(SLE)患者165例,根据是否发生NPSLE分为NPSLE组(77例)和非NPSLE组(88例),再根据系统性红斑狼疮疾病活动性指数2000(SLEDAI-2000)评分将NPSLE患者分为轻度组(23例)、中度组(32例)和重度组(22例)。比较NPSLE组和非NPSLE组患者入组年龄、发病时年龄、性别、SLE病程、临床特征(发热、血管炎性皮损、高血压、蝶形红斑、雷诺现象、关节炎、蛋白尿)、实验室生化指标[S100A8/A9、NfL、抗核抗体(ANA)、抗磷脂抗体(APA)、抗双链DNA抗体(dsDNA)抗体、抗干燥综合征A(SSA)抗体、抗干燥综合征抗原B(SSB)抗体、抗史密斯(SM)抗体、血沉(ESR)、白细胞计数(WBC)、血小板计数(PLT)、谷丙转氨酶(ALT)、谷草转氨酶(AST)]以及治疗方案(糖皮质激素、糖皮质激素联合羟氯喹、糖皮质激素联合免疫抑制剂)。采用Logistic回归分析SLE患者发生NPSLE的影响因素。绘制受试者工作特征(ROC)曲线分析S100A8/A9、NfL对SLE患者发生NPSLE的诊断价值。结果:NPSLE组发病年龄小于非NPSLE组,SLE病程大于非NPSLE组(均P<0.05)。NPSLE组发热比例、血管炎性皮损比例、APA阳性比例、ESR、ALT、AST、血清S100A8/A9、NfL水平高于非NPSLE组,WBC、PLT低于非NPSLE组(均P<0.05)。重度组血清S100A8/A9、NfL水平高于中度组和轻度组,且中度组高于轻度组(均P<0.05)。血清S100A8/A9、NfL水平是SLE 患者发生NPSLE的独立影响因素(均P<0.05)。血清S100A8/A9、NfL以及两者联合检测诊断NPSLE的曲线下面积(AUC)分别为0.724、0.730、0.902,且两者联合检测诊断价值大于血清S100A8/A9和NfL单项检测(均P<0.05)。结论:NPSLE患者血清S100A8/A9、NfL水平均升高,与疾病严重程度相关,是SLE 患者发生NPSLE的独立影响因素,两者联合检测对NPSLE的诊断价值更高。
Abstract:
Objective:To investigate the detection and significance of serum S100A8/A9 and neurofilament light chain(NfL)levels in patients with neuropsychiatric systemic lupus erythematosus(NPSLE).Methods:A total of 165 patients with systemic lupus erythematosus(SLE)were selected and divided into NPSLE group(77 cases)and non-NPSLE group(88 cases)according to the presence or absence of NPSLE.According to SLEDAI-2000 score,NPSLE patients were divided into mild group(23 cases),moderate group(32 cases)and severe group(22 cases).The NPSLE group and the non-NPSLE group were compared in terms of age at enrollment,age at onset,gender,course of SLE,clinical features(fever,vasculitic lesions,hypertension,butterfly erythema,Raynaud's phenomenon,arthritis,proteinuria),and laboratory biochemical indicators(S100A8/A9,NfL,antinuclear antibody [ANA],antiphospholipid antibody [APA],and anti-double-stranded DNA [dsDNA] antibody,anti-sjogren's syndrome A [SSA] antibody,anti-sjogren's syndrome antigen B [SSB] antibody,anti-smith [SM] antibody,erythrocyte sedimentation rate [ESR],white blood cell count [WBC],platelet count [PLT],alanine aminotransferase [ALT],aspartate aminotransferase [AST])and treatment regimens(glucocorticoids,glucocorticoids combined with hydroxychloroquine,glucocorticoids combined with immunosuppressants).Logistic regression was used to analyze the influencing factors of NPSLE in SLE patients.ROC curve was drawn to analyze the diagnostic value of S100A8/A9 and NfL for NPSLE in SLE patients.Results:Compared with the non-NPSLE group,the NPSLE group had a younger age of onset and a longer duration of SLE(all P<0.05).Compared with the non-NPSLE group,the NPSLE group had a significantly higher proportion of patients with fever,vasculitic skin lesions,APA positive rate,ESR,ALT,AST,serum S100A8/A9 and NfL levels,and significantly lower WBC and PLT(all P<0.05).The serum levels of S100A8/A9 and NfL in the severe group were higher than those in the moderate and mild groups,and those in the moderate group were higher than those in the mild group(all P<0.05).Serum levels of S100A8/A9 and NfL were independent influencing factors for NPSLE in SLE patients(both P<0.05).The AUC of serum S100A8/A9,NfL and the combined detection of the two in the diagnosis of NPSLE was 0.724,0.730 and 0.902 respectively,and the diagnostic value of the combined detection of the two was greater than that of serum S100A8/A9 or NfL alone(all P<0.05).Conclusion:Serum levels of S100A8/A9 and NfL are increased in NPSLE patients,which are correlated with the severity of the disease and are independent influencing factors for NPSLE in SLE patients.The combined detection of S100A8/A9 and NfL has a higher diagnostic value for NPSLE.

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备注/Memo

备注/Memo:
基金项目:重庆市自然科学基金资助面上项目(CSTC2019JCYJ-MXMX0569)
更新日期/Last Update: 2023-12-05