[1]杨淑娟,罗岳西,刘 俐,等.孕晚期孕妇产前抑郁影响因素及抑郁程度与血清促甲状腺激素、甲状腺过氧化物酶抗体相关性研究[J].陕西医学杂志,2023,52(12):1718-1722.[doi:DOI:10.3969/j.issn.1000-7377.2023.12.020]
　YANG Shujuan,LUO Yuexi,LIU Li,et al.Influencing factors of prenatal depression and correlation between depression degree and serum TSH and TPOAb in late pregnant women[J].,2023,52(12):1718-1722.[doi:DOI:10.3969/j.issn.1000-7377.2023.12.020]
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孕晚期孕妇产前抑郁影响因素及抑郁程度与血清促甲状腺激素、甲状腺过氧化物酶抗体相关性研究
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《陕西医学杂志》[ISSN:1000-7377/CN:61-1281/TN]

卷:
52
期数:
2023年12期
页码:
1718-1722
栏目:
临床研究
出版日期:
2023-12-05

文章信息/Info

Title:
Influencing factors of prenatal depression and correlation between depression degree and serum TSH and TPOAb in late pregnant women
作者:
杨淑娟; 罗岳西; 刘 俐; 周翠华
(南充市中心医院产科,四川 南充 637000)
Author(s):
YANG Shujuan; LUO Yuexi; LIU Li; ZHOU Cuihua
(Department of Obstetrics,Nanchong Central Hospital,Nanchong 637000,China)
关键词:
产前抑郁;  孕晚期;  影响因素;  促甲状腺激素;  甲状腺过氧化物酶抗体;  相关性
Keywords:
Prenatal depression;  Late pregnancy;  Influencing factors;  Thyroid-stimulating hormone;  Thyroid peroxidase antibody;  Correlation
分类号:
R 749.4
DOI:
DOI:10.3969/j.issn.1000-7377.2023.12.020
文献标志码:
A
摘要:
目的:探讨孕晚期孕妇产前抑郁的影响因素及抑郁程度与血清促甲状腺激素(TSH)、甲状腺过氧化物酶抗体(TPOAb)的相关性。方法:选取伴产前抑郁的孕晚期产妇108例为观察组,无产前抑郁的孕晚期产妇216例为对照组。采用临床自制问卷进行问卷调查并检测甲状腺功能指标[血清TSH、游离三碘甲状腺原氨酸(FT3)、游离甲状腺素(FT4)、TGAb、甲状腺过氧化物酶抗体(TPOAb)]。比较两组临床资料。采用Logistic回归分析孕妇产前抑郁的影响因素,然后构建模型并分析模型的预测价值。比较两组甲状腺功能指标。采用Pearson法分析甲状腺功能指标与抑郁自评量表(SDS)评分的相关性。结果:观察组大专以下文化程度、不良妊娠史、睡眠质量差的比例高于对照组(均P<0.05)。观察组中文版压力知觉量表(CPSS)总分高于对照组(P<0.05)。观察组和对照组家庭人均月收入、婆媳关系和夫妻关系分布情况比较,差异有统计学意义(均P<0.05)。家庭人均月收入、婆媳关系、夫妻关系、不良妊娠史、睡眠质量及CPSS总分是孕妇产前抑郁的独立影响因素(均P<0.05)。观察组TSH低于对照组,TPOAb高于对照组(均P<0.05)。TSH与SDS呈负相关(r=-0.682,P<0.05),TPO-Ab与SDS呈正相关(r=0.538,P<0.05)。 结论:不良妊娠史、家庭收入、婆媳及夫妻关系、睡眠质量、CPSS总分是孕晚期孕妇产前抑郁的因素影响。血清TSH和TPOAb水平与孕晚期孕妇产前抑郁程度相关。
Abstract:
Objective:To investigate the influence factors of prenatal depression and the correlation between the degree of depression and serum thyroid stimulating hormone(TSH)and thyroid peroxidase antibody(TPOAb)in late pregnant women.Methods:108 late pregnant women with prenatal depression were selected as the observation group and 216 without prenatal depression as the control group.A self-made clinical questionnaire was used to investigate thyroid function indexes(TSH,FT3,FT4,TGAb and TPOAb).The clinical data of the two groups were compared.Logistic regression was used to analyze the influencing factors of prenatal depression in pregnant women,and then the model was constructed and its predictive value was analyzed.Thyroid function indexes were compared between the two groups.The correlation between thyroid function indexes and SDS score was analyzed by Pearson method.Results:The proportion of under college education,adverse pregnancy history and poor sleep quality in observation group was higher than that in control group(all P<0.05).The total CPSS score of in the observation group was higher than that in the control group(P<0.05).There were significant differences between the observation group and the control group in the distribution of family per capita monthly income,the relationship between mother-in-law and daughter-in-law and the relationship between husband and wife(all P<0.05).Family per capita monthly income,relationship between mother-in-law and daughter-in-law,relationship between husband and wife,adverse pregnancy history,sleep quality and total CPSS score were independent influencing factors of prenatal depression(all P<0.05).TSH in observation group was lower than that in control group,and TPOAb was higher than that in control group(all P<0.05).TSH was negatively correlated with SDS(r=-0.682,P<0.05),and TPOAb was positively correlated with SDS(r=0.538,P<0.05).Conclusion:Adverse pregnancy history,family income,relationship between mother-in-law and daughter-in-law,relationship between husband and wife,sleep quality and CPSS score are the factors influencing prenatal depression in late pregnant women.Serum TSH and TPOAb levels in late pregnant women were correlated with the degree of prenatal depression.

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备注/Memo

备注/Memo:
基金项目:吴阶平医学基金会临床科研专项基金资助项目(320.6750.2021-25-5)
更新日期/Last Update: 2023-12-05