[1]张 令,敬 怡,刘 琪,等.整合DNA修复能力与核苷酸剪切修复标志物评估头颈鳞癌发病风险的初步研究[J].陕西医学杂志,2023,52(11):1502-1505.[doi:DOI:10.3969/j.issn.1000-7377.2023.11.011]
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整合DNA修复能力与核苷酸剪切修复标志物评估头颈鳞癌发病风险的初步研究
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《陕西医学杂志》[ISSN:1000-7377/CN:61-1281/TN]

卷:
52
期数:
2023年11期
页码:
1502-1505
栏目:
基础研究
出版日期:
2023-11-05

文章信息/Info

作者:
张 令1; 2; 敬 怡3; 刘 琪1; 张晓彤2; 韩 鹏1
(1.西安交通大学第一附属医院耳鼻咽喉头颈外科,陕西 西安710061; 2.西安交通大学第二附属医院耳鼻咽喉头颈外科,陕西 西安710004; 3.山阳县人民医院耳鼻喉科,陕西 山阳726400)
关键词:
头颈鳞癌;  核苷酸剪切修复基因;  DNA 修复能力;  肿瘤易感性;  肿瘤风险;  整合
分类号:
R 739.8
DOI:
DOI:10.3969/j.issn.1000-7377.2023.11.011
文献标志码:
A
摘要:
目的:探讨通过整合DNA修复能力和核苷酸剪切修复基因表达来评估头颈部鳞状细胞癌(HNSCC)的发病风险。方法:82例HNSCC患者作为研究对象,选择性别和年龄与患者匹配的81例健康人作为正常对照组,研究对象均来自中国汉族人群。使用宿主细胞再活化(HCR)实验来测定HNSCC患者和对照者的DNA修复能力(DRC); 使用qPCR实验检测HNSCC患者和对照组外周血淋巴细胞中9个核心NER基因的mRNA相对表达水平; 使用Logistic回归分析DRC和NER mRNA表达水平之间的相关性; 使用受试者工作特征曲线(ROC)评估整合DRC和NER mRNA表达水平对HNSCC风险预测的效能。结果:HNSCC患者DRC的平均水平(9.84±2.32)%明显低于对照组(10.35±2.42)%(P=0.013)。DRC水平与NER基因mRNA表达水平相关性研究发现DRC与XPA之间存在关联(P=0.031)。与单一水平相比,DRC水平曲线下面积显著提高(P=0.043)。同时,将NER mRNA表达水平整合到ROC曲线中,与仅含DRC的水平相比,含DRC和XPA mRNA的水平曲线下面积明显提高(P=0.046)。结论:整合DRC和NER mRNA表达对HNSCC发病风险的预测效能显著提高。相比于只包含一种表型的水平,整合两种标志物能更有效地评估HNSCC的发病风险。

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备注/Memo

备注/Memo:
基金项目:陕西省自然科学基础研究计划面上项目(2023-JC-YB-791); 西安交通大学第一附属医院院基金资助项目(2021ZYTS-02)
更新日期/Last Update: 2023-11-06