[1]周立新,孙忠人,尹洪娜.热休克蛋白70促进脊髓损伤恢复研究进展[J].陕西医学杂志,2023,52(10):1434-1437.[doi:DOI:10.3969/j.issn.1000-7377.2023.10.035]
　ZHOU Lixin,SUN Zhongren,YIN Hongna.Research progress of Hsp70 promoting spinal cord injury recovery[J].,2023,52(10):1434-1437.[doi:DOI:10.3969/j.issn.1000-7377.2023.10.035]
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热休克蛋白70促进脊髓损伤恢复研究进展
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《陕西医学杂志》[ISSN:1000-7377/CN:61-1281/TN]

卷:
52
期数:
2023年10期
页码:
1434-1437
栏目:
综 述
出版日期:
2023-10-05

文章信息/Info

Title:
Research progress of Hsp70 promoting spinal cord injury recovery
作者:
周立新1; 孙忠人1; 尹洪娜2
(1.黑龙江中医药大学,黑龙江 哈尔滨150040; 2.黑龙江中医药大学附属第二医院,黑龙江 哈尔滨150006)
Author(s):
ZHOU Lixin; SUN Zhongren; YIN Hongna
(Heilongjiang University of Chinese Medicine,Harbin 150040,China)
关键词:
热休克蛋白70;  脊髓损伤;  分子伴侣作用;  抑制炎症反应;  抑制凋亡反应;  抗氧化应激
Keywords:
Spinal cord injury;  Heat shock protein 70;  Molecular chaperone;  Inhibiting inflammatory response;  Inhibiting apoptosis response;  Anti-oxidative stress
分类号:
R 744
DOI:
DOI:10.3969/j.issn.1000-7377.2023.10.035
文献标志码:
A
摘要:
脊髓损伤(SCI)是由椎骨骨折或脱位造成的一种高致残率疾病,严重降低患者生活质量。热休克蛋白(Hsps)是正常的细胞内蛋白,在细胞受到应激或损伤时大量产生。热休克蛋白70(Hsp70)是热休克蛋白家族中的重要成员,该蛋白已被证明在SCI后的继发性损伤调节中起着关键作用。故对SCI后,Hsp70的产生和作用机制进行综述,以期为后续相关研究提供参考。
Abstract:
Spinal cord injury(SCI)is a highly disabling disease caused by fracture or dislocation of vertebrae,which seriously reduces the quality of life of patients.Heat shock proteins(Hsps)are normal intracellular proteins that are produced in large quantities when cells are stressed or damaged.Hsp70 is an important member of the heat shock protein family,which has been shown to play a key role in the regulation of secondary injury after spinal cord injury(SCI).This paper mainly reviews the generation and mechanism of Hsp70 after SCI,in order to provide reference for subsequent relevant studies.

参考文献/References:

[1] Ahuja CS,Nori S,Tetreault L,et al.Traumatic spinal cord injury-repair and regeneration[J].Neurosurgery,2017,80(3S):s9-s22.
[2] Sun X,Jones ZB,Chen XM,et al.Multiple organ dysfunction and systemic inflammation after spinal cord injury:A complex relationship[J].Neuroinflammation,2016,13(1):260.
[3] Alizadeh A,Dyck SM.Traumatic spinal cord injury:An overview of pathophysiology,models and acute injury mechanisms[J].Front Neurol,2019,10:282.
[4] Bond U,Schlesinger MJ.Heat-shock proteins and development[J].Adv Genet,1987,24:1-29.
[5] Ikwegbue PC,Masamba P,Oyinloye BE,et al.Roles of heat shock proteins in apoptosis,oxidative stress,human inflammatory diseases,and cancer[J].Pharmaceuticals(Basel),2017,11(1):2.
[6] Dzaman-Serafin S,Telatyńska-Mieszek B,Ciechanowski K,et al.Heat shock proteins and their characteristics[J].Pol Merkur Lekarski,2005,19(110):215-219.
[7] Saibil H.Chaperone machines for protein folding,unfolding and disaggregation[J].Nat Rev Mol Cell Biol,2013,14(10):630-642.
[8] Faust O,Abayev-Avraham M,Wentink AS,et al.HSP40 proteins use class-specific regulation to drive HSP70 functional diversity[J].Nature,2020,587(7834):489-494.
[9] Alderson TR,Kim JH,Markley JL.Dynamical structures of Hsp70 and Hsp70-Hsp40 complexes[J].Structure,2016,24(7):1014-1030.
[10] Bracher A,Verghese J.The nucleotide exchange factors of Hsp70 molecular chaperones[J].Front Mol Biosci,2015,7(2):10.
[11] Murphy ME.The HSP70 family and cancer[J].Carcinogenesis,2013,34(6):1181-1188.
[12] Sottile ml,Nadin SB.Heat shock proteins and DNA repair mechanisms:An updated overview[J].Cell Stress Chaperones,2018,23(3):303-315.
[13] Penke B,Bogár F,Crul T,et al.Heat shock proteins and autophagy pathways in neuroprotection:From molecular bases to pharmacological interventions[J].Int J Mol Sci,2018,19(1):325.
[14] Han WS,Yoo JY,Youn SW,et al.Effects of C2-ceramide on the Malme-3M melanoma cell line[J].J Dermatol Sc,2002,30(1):10-19.
[15] Driedonks N,Xu J,Peters JL,et al.Multi-Level interactions between heat shock factors,heat shock proteins,and the redox system regulate acclimation to heat[J].Front Plant Sci,2015,6:999.
[16] Song G,Cechvala C,Resnick DK,et al.Gene chip analysis after acute spinal cord injury in rat[J].Neurochem,2001,79(4):804-815.
[17] Mogk A,Bukau B,Kampinga HH.Cellular handling of protein aggregates by disaggregation machines[J].Mol Cell,2018,69(2):214-226.
[18] Odashima M,Otaka M,Matsuhashi T,et al.Mechanical strain stress suppresses expression of HSP70 and wound restoration in gastric mucosal cells[J].Dig Dis Sci,2007,52(11):3087-3091.
[19] Wang K,Liu JQ,Zhong T,et al.Phase separation and cytotoxicity of tau are modulated by protein disulfide isomerase and s-nitrosylation of this molecular chaperone[J].J Mol Biol,2020,432(7):2141-2163.
[20] Faden AI,Wu J,Stoica BA,et al.Progressive inflammation-mediated neurodegeneration after traumatic brain or spinal cord injury[J].Br J Pharmacol,2016,173(4):681-691.
[21] 党仟仟,周宾宾,曾俊林,等.温针灸对大鼠脊髓损伤节段神经再生抑制因子RhoA、RockⅡ表达的影响[J].陕西中医,2022,43(11):1495-1500.
[22] Chamney C,Godar M,Garrigan E,et al.Effects of glutamine supplementation on muscle function and stress responses in a mouse model of spinal cord injury[J].Exp Physiol,2013,98(3):796-806.
[23] Xu B,Wang J,Liu S,et al.HSP70 alleviates spinal cord injury by activating the NF-κB pathway[J].Musculoskelet Neuronal Interact,2021,21(4):542-549.
[24] Yang YC,Li CK,Wei YL,et al.Docosahexaenoic acid inhibition of inflammation is partially via cross-talk between Nrf2/heme oxygenase 1 and IKK/NF-κB pathways[J].J Nutr Biochem,2013,24(1):204-212.
[25] De-Jong PR,Schadenberg AW,Jansen NJ,et al.Hsp70 and cardiac surgery:Molecular chaperone and inflammatory regulator with compartmentalized effects[J].Cell Stress Chaperones,2009,14(2):117-131.
[26] Wang C,Liu Y,Wang Y,et al.Lowfrequency pulsed electromagnetic field promotes functional recovery,reduces inflammation and oxidative stress,and enhances HSP70 expression following spinal cord injury[J].Mol Med Rep,2019,19(3):1687-1693.
[27] Bock FJ,Tait SWG.Mitochondria as multifaceted regulators of cell death[J].Nat Rev Mol Cell Biol,2020,21(2):85-100.
[28] 崔 佳,刘敏丽.乙酰左旋肉碱对脊髓损伤后线粒体的保护作用研究进展[J].陕西医学杂志,2021,50(3):374-376.
[29] Alizadeh A,Dyck SM,Karimi-Abdolrezaee S.Traumatic spinal cord injury:An overview of pathophysiology,models and acute injury mechanisms[J].Front Neurol,2019,10:282.
[30] Nasouti R,Khaksari M,Mirzaee M,et al.Trehalose protects against spinal cord injury through regulating heat shock proteins 27 and 70 and caspase-3 genes expression[J].J Basic Clin Physiol Pharmacol,2019,31(1):125-128.
[31] Guo F,Sigua C,Bali P,et al.Mechanistic role of heat shock protein 70 in Bcr-Abl-mediated resistance to apoptosis in human acute leukemia cells[J].Blood,2005,105(3):1246-1255.
[32] Kelly S,Yenari MA.Neuroprotection:Heat shock proteins[J].Curr Med Res Opin,2002,2:s55-s60.
[33] Gabai VL,Mabuchi K,Mosser DD,et al.Hsp72 and stress kinase c-jun N-terminal kinase regulate the bid-dependent pathway in tumor necrosis factor-induced apoptosis[J].Mol Cell Biol,2002,22(10):3415-3424.
[34] Xu L,Giffard RG.HSP70 protects murine astrocytes from glucose deprivation injury[J].Neurosci Lett,1997,224(1):9-12.
[35] 朱 兴,戴朝六,淮明生.缺血预处理对肝硬化大鼠肝脏缺血再灌注损伤保护作用的研究[J].临床和实验医学杂志,2007,33(5):5-6.
[36] Shen SQ,Zhang Y,Xiang JJ,et al.Protective effect of curcumin against liver warm ischemia/reperfusion injury in rat model is associated with regulation of heat shock protein and antioxidant enzymes[J].World J Gastroenterol,2007,13(13):1953-1961.

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备注/Memo

备注/Memo:
基金项目:国家自然科学基金资助面上项目(81873378)
更新日期/Last Update: 2023-10-07