[1]韩 慧,徐 平,宋卫东.慢性阻塞性肺疾病患者气道炎症反应、肺功能与生化指标相关性研究[J].陕西医学杂志,2023,52(10):1358-1361,1366.[doi:DOI:10.3969/j.issn.1000-7377.2023.10.016]
　HAN Hui,XU Ping,SONG Weidong.Correlation analysis of airway inflammatory response,pulmonary function and biochemical indicators in patients with COPD[J].,2023,52(10):1358-1361,1366.[doi:DOI:10.3969/j.issn.1000-7377.2023.10.016]
点击复制

慢性阻塞性肺疾病患者气道炎症反应、肺功能与生化指标相关性研究

《陕西医学杂志》[ISSN:1000-7377/CN:61-1281/TN]

卷:
52
期数:
2023年10期
页码:
1358-1361,1366
栏目:
临床研究
出版日期:
2023-10-05

文章信息/Info

Title:
Correlation analysis of airway inflammatory response,pulmonary function and biochemical indicators in patients with COPD
作者:
韩 慧; 徐 平; 宋卫东
(北京大学深圳医院呼吸与危重症医学科,广东 深圳 518036)
Author(s):
HAN Hui; XU Ping; SONG Weidong
(Department of Respiratory and Critical Care Medicine,Shenzhen Hospital,Peking University,Shenzhen 518036,China)
关键词:
慢性阻塞性肺疾病;  气道炎症;  肺功能;  1; 25-二羟基维生素D3;  血清钙;  血清镁
Keywords:
Chronic obstructive pulmonary disease;  Airway inflammation;  Pulmonary function;  1; 25(OH)2D3;  Serum calcium;  Serum magnesium
分类号:
R 563.9
DOI:
DOI:10.3969/j.issn.1000-7377.2023.10.016
文献标志码:
A
摘要:
目的:分析慢性阻塞性肺疾病(COPD)患者气道炎症反应、肺功能、血清1,25-二羟基维生素D3[1,25(OH)2D3]、钙离子(Ca2+)、镁离子(Mg2+)水平变化,并探究气道炎症反应、肺功能与血清1,25(OH)2D3 、Ca2+、Mg2+的相关性。方法:选择COPD住院患者48例(急性加重组)和COPD门诊随访患者48例(稳定组),以40例同期无COPD病史的健康者为对照组。检测三组呼出气一氧化氮(FeNO)、C反应蛋白(CRP)、降钙素原(PCT)、第一秒用力呼气末容积(FEV1)、一秒率(FEV1/FVC)、血清1,25(OH)2D3 、Ca2+和Mg2+,并分析FeNO、CRP、PCT、FEV1、FEV1/FVC水平与1,25(OH)2D3 、Ca2+、Mg2+水平的相关性。结果:随着COPD病情进展,患者FEV1、FEV1/FVC、1,25(OH)2D3 、Ca2+、Mg2+水平均降低,急性加重组1,25(OH)2D3 、Ca2+、Mg2+水平低于稳定组,同时患者FeNO、CRP、PCT水平均升高,急性加重组的FeNO、CRP、PCT水平高于稳定组(均P<0.05)。FeNO、CRP、PCT水平分别与1,25(OH)2D3 、Ca2+、Mg2+水平呈负相关(均P<0.05),FEV1、FEV1/FVC水平分别与1,25(OH)2D3 、Ca2+、Mg2+水平呈正相关(均P<0.05)。CRP、PCT是COPD急性加重的危险因素(均P<0.05),FEV1、FEV1/FVC、1,25(OH)2D3 是COPD急性加重的保护因素(均P<0.05)。结论:气道炎症与1,25(OH)2D3 、Ca2+、Mg2+水平呈负相关,肺功能与1,25(OH)2D3 、Ca2+、Mg2+水平呈正相关,CRP、PCT是COPD急性加重的危险因素,FEV1、FEV1/FVC、1,25(OH)2D3 是COPD急性加重的保护因素,其具体机制还有待深入研究。
Abstract:
Objective:To analyze the changes of airway inflammatory response,pulmonary function and serum 1,25-dihydroxyvitamin D3 [1,25(OH)2D3 ],calcium ion(Ca2+)and magnesium ion(Mg2+)levels in patients with chronic obstructive pulmonary disease(COPD),and investigate the correlation between airway inflammation,lung function and serum 1,25(OH)2D3,Ca2+,Mg2+.Methods:Forty-eight inpatients with COPD(acute exacerbation group)and 48 outpatients with COPD(stable group)were selected,and 40 healthy people without COPD history were selected as control group.The levels of fractional exhaled nitric oxide(FeNO),C-reactive protein(CRP),procalcitonin(PCT),forced end-expiratory volume in one second(FEV1),forced expiratory volume in one second(FEV1/FVC),serum 1,25(OH)2D3,Ca2+ and Mg2+ were measured.The correlations of FeNO,CRP,PCT,FEV1,FEV1/FVC with 1,25(OH)2D3,Ca2+,Mg2+ levels were analyzed.Results:With the progression of COPD,FEV1,FEV1/FVC,1,25(OH)2D3,Ca2+ and Mg2+ levels decreased.The levels of 1,25(OH)2D3,Ca2+ and Mg2+ in acute exacerbation group were lower than those in stable group,and the levels of FeNO,CRP and PCT increased,and the levels in acute exacerbation group were higher than those in stable group (all P<0.05).The levels of FeNO,CRP and PCT were negatively correlated with the levels of 1,25(OH)2D3,Ca2+ and Mg2+ (all P<0.05).FEV1 and FEV1/FVC were positively correlated with the levels of 1,25(OH)2D3,Ca2+ and Mg2+ (all P<0.05).CRP and PCT were risk factors for COPD acute exacerbation(all P<0.05),and FEV1,FEV1/FVC,1,25(OH)2D3 were protective factors for COPD acute exacerbation(all P<0.05).Conclusion:Airway inflammation is negatively correlated with the levels of 1,25(OH)2D3,Ca2+ and Mg2+. Pulmonary function is positively correlated with the levels of 1,25(OH)2D3,Ca2+ and Mg2+.CRP and PCT are risk factors of COPD acute exacerbation,and FEV1,FEV1/FVC,1,25(OH)2D3 are protective factors of COPD acute exacerbation,but the specific mechanism needs further study.

参考文献/References:

[1] Christenson SA,Smith BM,Bafadhel M,et al.Chronic obstructive pulmonary disease[J].Lancet,2022,399(10342):2227-2242.
[2] 李正欢,张晓云,陈 杨,等.基于2021年GOLD《COPD诊断、治疗与预防全球策略》解析慢性阻塞性肺疾病稳定期非药物管理策略[J].中国全科医学,2022,25(2):131-138.
[3] 王雅宁,米 婷,周 红.不同通气模式治疗慢性阻塞性肺疾病合并呼吸衰竭临床疗效及患者呼吸动力学、肺功能水平比较[J].陕西医学杂志,2023,52(1):36-39,44.
[4] 唐万云,曾玉英,汪秀玲,等.益气活血方治疗慢性阻塞性肺疾病稳定期疗效及对患者肺功能、炎症因子的影响[J].陕西中医,2020,41(11):1576-1579,1583.
[5] 周 海,王妍敏,郏 琴,等.不同表型的重度稳定期COPD患者生活质量和营养状况的比较分析[J].现代生物医学进展,2021,21(20):3867-3870,3911.
[6] 瞿香坤,曹利芳,夏 静,等.25羟维生素D测定在慢性阻塞性肺疾病中的研究[J].临床肺科杂志,2019,24(7):1221-1224.
[7] 杨晓春,段玲玲.血清镁离子水平在儿童支气管哮喘急性发作期的临床应用价值[J].中国卫生检验杂志,2021,31(7):856-858,869.
[8] 史凌改,张 罗.钙离子在呼吸道纤毛运动调控机制中的作用[J].国际耳鼻咽喉头颈外科杂志,2009,33(2):63-66.
[9] 中华医学会呼吸病学分会慢性阻塞性肺疾病学组,中国医师协会呼吸医师分会慢性阻塞性肺疾病工作委员会.慢性阻塞性肺疾病诊治指南(2021年修订版)[J].中华结核和呼吸杂志,2021,44(3):170-205.
[10] 国家卫生健康委员会急诊医学质控中心,中华医学会急诊医学分会,中国医师协会急诊医师分会,等.中国慢性阻塞性肺疾病急性加重中西医诊治专家共识(2021)[J].中华危重病急救医学,2021,33(11):1281-1290.
[11] Kaur M,Chandel J,Malik J,et al.Particulate matter in COPD pathogenesis:An overview[J].Inflamm Res,2022,71(7-8):797-815.
[12] Joo J,Himes B.Gene-based analysis reveals sex-specific genetic risk factors of COPD[J].AMIA Annu Symp Proc,2022,2(21):601-610.
[13] Nucera F,Mumby S,Paudel KR,et al.Role of oxidative stress in the pathogenesis of COPD[J].Minerva Med,2022,113(3):370-404.
[14] 张连霞,赵慧霞,于世杰,等.老年慢性阻塞性肺疾病病人中炎症因子、25-羟维生素D3水平变化及急性发作的相关危险因素[J].实用老年医学,2020,34(3):250-253.
[15] 陈 锋,乜庆荣,韩雪峰,等.血清镁离子与慢性阻塞性肺疾病急性加重次数及生活质量的相关性分析[J].实用老年医学,2019,33(7):653-656.
[16] 侯英宇,刘晨阳,张丹梅,等.COPD急性加重期细菌感染对Th17/Treg平衡及炎性因子水平的影响[J].疑难病杂志,2020,19(8):799-803.
[17] 张盛斌,郑吼真,张淇钏,等.血清25-羟维生素D水平与COPD急性加重期患者免疫炎症指标、CAT评分的相关性研究[J].广东药科大学学报,2020,36(5):719-723.
[18] 王丽娟,陈 旭,吴旭佳,等.血清25(OH)D对COPD患者肺功能及炎性因子的影响[J].浙江医学,2021,43(3):317-319.
[19] 崔立慧,李素娟,陶建娇.COPD急性加重期与稳定期患者血清白细胞介素水平变化及其与肺功能的相关性[J].川北医学院学报,2021,36(11):1516-1518,1540.
[20] 祁永梅,马祥生,胡雪甫,等.TAT、25-(OH)D及D-D水平与COPD患者肺功能的相关性研究[J].河北医药,2019,41(9):1329-1332.

相似文献/References:

[1]马明铭,李 芳,杨 慧,等.噻托溴胺粉雾剂联合非药物康复方案对慢性阻塞性肺疾病患者BODE指数的影响[J].陕西医学杂志,2019,(4):515.
　MA Mingming,LI Fang,YANG Hui,et al.Effect of tiotropium bromide powder and nonpharmacological rehabilitation program on BODE index in patients with chronic obstructive pulmonary disease[J].,2019,(10):515.
[2]朱小川.血小板/淋巴细胞比值预测慢性阻塞性肺疾病急性加重期〖JZ〗伴有早期肾功能损害临床价值[J].陕西医学杂志,2019,(10):1353.
　ZHU Xiaochuan..Clinical value of platelet/lymphocyte ratio in predicting early renal impairment〖JZ〗 in acute exacerbation of chronic obstructive pulmonary disease[J].,2019,(10):1353.
[3]张军营.吸烟对慢阻肺患者血清S100A8/A9、8异前列腺素F2α、组织蛋白酶S及其它炎症因子表达水平的影响*[J].陕西医学杂志,2019,(11):1426.
[4]焦文妤,尚家璐,李树霞△.慢性阻塞性肺疾病患者血清补体C1q肿瘤坏死因子相关蛋白5与肺功能及炎症反应相关性研究[J].陕西医学杂志,2019,(12):1616.
[5]陈辅萍.慢性阻塞性肺疾病并发感染性肺炎危险因素分析[J].陕西医学杂志,2020,49(1):102.
[6]薛佩妮,冯敏娟△,王惠琴.噻托溴铵粉联合糖皮质激素治疗慢性阻塞性肺疾病疗效及对患者生活质量评分的影响*[J].陕西医学杂志,2020,49(2):216.
　XUE Peini,FENG Minjuan,WANG Huiqin..Efficacy of tiotropium bromide combined with glucocorticoids in the treatment of COPD and its effect on patients' quality of life score[J].,2020,49(10):216.
[7]焦文妤,高爱华△.血清可溶性髓系细胞触发受体-1与临床肺部感染评分在慢性阻塞性肺疾病呼吸机相关性肺炎早期诊断及预后判断中的效能研究[J].陕西医学杂志,2020,49(12):1630.[doi:DOI:10.3969/j.issn.1000-7377.2020.12.024]
　JIAO Wenyu,GAO Aihua..Effectiveness of sTREM-1 and CPIS in early diagnosis and prognosis judgment of ventilator-associated pneumonia in COPD[J].,2020,49(10):1630.[doi:DOI:10.3969/j.issn.1000-7377.2020.12.024]
[8]张卓红,赵拖利.慢性阻塞性肺疾病大鼠血液、支气管灌洗液中水通道蛋白及p-c-Jun-N-末端激酶表达情况实验研究[J].陕西医学杂志,2021,50(7):776.[doi:DOI:10.3969/j.issn.1000-7377.2021.07.002]
　ZHANG Zhuohong,ZHAO Tuoli.Expression of AQP-1 and p-JNK in blood and bronchial lavage fluid of rats with COPD[J].,2021,50(10):776.[doi:DOI:10.3969/j.issn.1000-7377.2021.07.002]
[9]余 刚,张飔雪.慢性阻塞性肺疾病急性加重期患者血清干扰素-γ、甲壳质酶蛋白-40水平及与预后、肺功能相关性分析[J].陕西医学杂志,2021,50(10):1223.[doi:DOI:10.3969/j.issn.1000-7377.2021.10.011]
　YU Gang,ZHANG Sixue.The levels of INF-γ and YKL-40 in patients with AECOPD and their correlation with prognosis and lung function[J].,2021,50(10):1223.[doi:DOI:10.3969/j.issn.1000-7377.2021.10.011]
[10]康 睿,张亚琼.阿比多尔对慢性阻塞性肺疾病大鼠气道炎症及气道黏液高分泌影响的实验研究[J].陕西医学杂志,2022,51(4):391.[doi:DOI:10.3969/j.issn.1000-7377.2022.04.002]
　KANG Rui,ZHANG Yaqiong.Effect of abidol on airway inflammation and airway mucus hypersecretion in rats with chronic obstructive pulmonary disease[J].,2022,51(10):391.[doi:DOI:10.3969/j.issn.1000-7377.2022.04.002]

备注/Memo

备注/Memo:
基金项目:广东省深圳市科技计划项目(201103004)
更新日期/Last Update: 2023-10-07