[1]王俐慧,苏东风,隋汝波.脑小血管病患者血清甲壳质酶蛋白40、视锥蛋白样蛋白1表达特征及与认知障碍相关性研究[J].陕西医学杂志,2023,52(8):1038-1041,1046.[doi:DOI:10.3969/j.issn.1000-7377.2023.08.022]
　WANG Lihui,SU Dongfeng,SUI Rubo.Expression characteristics of YKL-40 and VILIP-1 in serum and their relationship with cognitive impairment in patients of cerebrovascular disease[J].,2023,52(8):1038-1041,1046.[doi:DOI:10.3969/j.issn.1000-7377.2023.08.022]
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脑小血管病患者血清甲壳质酶蛋白40、视锥蛋白样蛋白1表达特征及与认知障碍相关性研究
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《陕西医学杂志》[ISSN:1000-7377/CN:61-1281/TN]

卷:
52
期数:
2023年8期
页码:
1038-1041,1046
栏目:
临床研究
出版日期:
2023-08-05

文章信息/Info

Title:
Expression characteristics of YKL-40 and VILIP-1 in serum and their relationship with cognitive impairment in patients of cerebrovascular disease
作者:
王俐慧1; 苏东风1; 隋汝波2
(1.锦州医科大学解放军北部战区空军医院研究生培养基地,辽宁 沈阳 110042; 2.锦州医科大学附属第一医院,辽宁 锦州121012)
Author(s):
WANG Lihui; SU Dongfeng; SUI Rubo
(Postgraduate Training Base of PLA Northern War Zone Air Force Hospital,Jinzhou Medical University,Shenyang 110042,China)
关键词:
脑小血管病;  甲壳质酶蛋白40;  视锥蛋白样蛋白1;  认知障碍;  相关性;  血清
Keywords:
Cerebral small vessel disease;  Chitin enzymes protein 40;  Visinin-like protein 1;  Cognitive impairment;  Correlation;  Serum
分类号:
R 741
DOI:
DOI:10.3969/j.issn.1000-7377.2023.08.022
文献标志码:
A
摘要:
目的:观察脑小血管病(CSVD)患者血清甲壳质酶蛋白40(YKL-40)、视锥蛋白样蛋白1(VILIP-1)表达特征,探讨两者与认知障碍的相关性。方法:收集CSVD患者共63例作为观察组,收集体检证实为无明显器质性疾病的成人(健康成人)血清标本63例作为对照组,应用ELISA法检测血清中YKL-40和VILIP-1的表达。应用蒙特利尔认知评估量表(MoCA)评估认知障碍情况。结果:观察组血清中YKL-40和VILIP-1的表达量明显高于对照组(均P<0.05),观察组MoCA评分明显低于对照组(P<0.05)。观察组中YKL-40和VILIP-1在有无高血压、有无糖尿病病史、有无认知障碍分组中的表达差异有统计学意义(均P<0.05),观察组中MoCA在有无高血压、有无糖尿病病史分组评分中的差异有统计学意义(均P<0.05)。观察组血清中YKL-40和VILIP-1的表达具有正相关性(r=0.62,P=0.032),YKL-40和MoCA 评分(r=-0.61,P=0.025)、VILIP-1和MoCA评分(r=-0.68,P=0.011)均具有负相关性。结论:CSVD患者血清中存在YKL-40和VILIP-1高表达的状态,不仅与病变的形成有关,还与认知障碍相关。
Abstract:
Objective:To observe the expression characteristics of serum chitin enzymes protein 40(YKL-40)and visinin-like protein 1(VILIP-1)in patients with cerebral small vessel disease(CSVD),and to explore their correlation with cognitive impairment.Methods:A total of 63 CSVD patients were collected as the observation group,and 63 healthy adults were collected as the control group.The expressions of YKL-40 and VILPI-1 were detected by ELISA.Cognitive impairment was evaluated by MoCA.Results:Expression levels of YKL-40 and VILIP-1 in the observation group were significantly higher than those in the control group(all P<0.05).MOCA score in the observation group was significantly lower than that in the control group(P<0.05).In the observation group,there were significant differences in the expressions of YKL-40 and VILIP-1 in the groups with or without hypertension,diabetes history and cognitive impairment(all P<0.05),and there were significant differences in MoCA scores in the groups with or without hypertension and diabetes history(all P<0.05).Positive correlation was found between YKL-40 and VILIP-1 in the observation group(r=0.62,P=0.032).Negative correlation was found between YKL-40 and MOCA score(r=-0.61,P=0.025),VILIP-1 and MOCA score(r=-0.68,P=0.011).Conclusion:High expression of serum YKL-40 and VILIP-1 is related not only to the formation of lesions,but also to cognitive impairmen in CSVD patients.

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备注/Memo

备注/Memo:
基金项目:国家自然科学基金资助项目(81371461)
更新日期/Last Update: 2023-08-07