[1]朱苏迪,魏晓博,闫 凛,等.具有抗菌性能骨组织修复材料研究进展[J].陕西医学杂志,2023,52(6):768-770，774.[doi:DOI:10.3969/j.issn.1000-7377.2023.06.029]
　ZHU Sudi,WEI Xiaobo,YAN Lin,et al.Research progress of bone tissue repair materials with antibacterial properties[J].,2023,52(6):768-770，774.[doi:DOI:10.3969/j.issn.1000-7377.2023.06.029]
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具有抗菌性能骨组织修复材料研究进展
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《陕西医学杂志》[ISSN:1000-7377/CN:61-1281/TN]

卷:
52
期数:
2023年6期
页码:
768-770，774
栏目:
综 述
出版日期:
2023-06-05

文章信息/Info

Title:
Research progress of bone tissue repair materials with antibacterial properties
作者:
朱苏迪; 魏晓博; 闫 凛; 樊晓霞; 李宝莉
(延安大学医学院,陕西 延安 716000)
Author(s):
ZHU Sudi; WEI Xiaobo; YAN Lin; FAN Xiaoxia; LI Baoli
(Medical College,Yan'an University,Yan'an 716000,China)
关键词:
骨组织修复材料;  复合无机抗菌剂;  复合有机抗菌剂;  仿生纳米结构表面抗菌剂;  生物相容性
Keywords:
Bone tissue repair materials;  Composite inorganic antibacterial agent;  Composite organic antibacterial agent;  Biomimetic nano-structure surface antibacterial agent;  Biocompatibility
分类号:
R 318.08
DOI:
DOI:10.3969/j.issn.1000-7377.2023.06.029
文献标志码:
A
摘要:
开放性骨折、关节炎(OA)和骨质疏松(OP)等疾病所导致的骨缺损修复术后抗感染已成为临床治疗上的一个难题。骨科围手术期大量应用抗生素易导致细菌耐药并加重患者的经济负担,因此开发非抗生素途径的抗菌骨修复材料是国内外众多科学家的追求与愿景。目前,非负载抗生素的骨修复材料主要有复合无机抗菌剂、复合有机抗菌剂和仿生纳米结构表面抗菌剂三类。现从抗菌作用、生物相容性和各自优缺点对上述三类骨修复材料进行综述,以期为开发新型具有抗菌和成骨作用的多功能骨修复材料提供新思路。
Abstract:
It has become a difficult problem in clinical treatment to prevent infection after the repair of bone defects caused by open fractures,osteoarthritis(OA)and osteoporosis(OP).A large number of antibiotics used in perioperative period of orthopedics can easily lead to bacterial resistance and increase the economic burden of patients.Therefore,the development of non-antibiotic antimicrobial bone repair materials is the pursuit and vision of many scientists at home and abroad.At present,the main bone repair materials that are not loaded with antibiotics include composite inorganic antibacterial agents,composite organic antibacterial agents and biomimetic nano-structure surface antibacterial agents.The above three types of bone repair materials have been reviewed mainly in terms of antibacterial effects,biocompatibility and their respective advantages and disadvantages to provide new ideas for the development of new multi-functional bone repair materials with antibacterial and osteogenic effects.

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备注/Memo

备注/Memo:
基金项目:陕西省自然科学基金资助项目(2022JM-547)
更新日期/Last Update: 2023-06-05