[1]何 冬,喻 杉,陈 露.急性骨髓炎患者血清红细胞沉降率、白细胞、降钙素原和白细胞介素-6水平变化及意义研究[J].陕西医学杂志,2023,52(6):709-713.[doi:DOI:10.3969/j.issn.1000-7377.2023.06.016]
　HE Dong,YU Shan,CHEN Lu.Changes and significance of serum erythrocyte sedimentation rate,white blood cell,procalcitonin and interleukin-6 in patients with acute osteomyelitis[J].,2023,52(6):709-713.[doi:DOI:10.3969/j.issn.1000-7377.2023.06.016]
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急性骨髓炎患者血清红细胞沉降率、白细胞、降钙素原和白细胞介素-6水平变化及意义研究
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《陕西医学杂志》[ISSN:1000-7377/CN:61-1281/TN]

卷:
52
期数:
2023年6期
页码:
709-713
栏目:
临床研究
出版日期:
2023-06-05

文章信息/Info

Title:
Changes and significance of serum erythrocyte sedimentation rate,white blood cell,procalcitonin and interleukin-6 in patients with acute osteomyelitis
作者:
何 冬1; 喻 杉1; 陈 露2
(1.四川省骨科医院骨病科,四川 成都 610041; 2.四川省骨科医院检验科,四川 成都 610041)
Author(s):
HE Dong; YU Shan; CHEN Lu
(Department of Osteopathy,Sichuan Province Orthopedic Hospital,Chengdu 610041,China)
关键词:
急性骨髓炎;  红细胞沉降率;  白细胞;  降钙素原;  白细胞介素-6;  病情严重程度
Keywords:
Acute osteomyelitis;  Erythrocyte sedimentation rate;  White blood cell;  Procalcitonin;  Interleukin-6;  Severity of illness
分类号:
R 551.3
DOI:
DOI:10.3969/j.issn.1000-7377.2023.06.016
文献标志码:
A
摘要:
目的:分析急性骨髓炎(AOL)患者血清红细胞沉降率(ESR)、白细胞(WBC)、降钙素原(PCT)和白细胞介素-6(IL-6)水平变化及意义。方法:选取AOL患者103例为AOL组,并依照临床严重程度分为轻度组(42例)、中度组(35例)及重度组(26例)。另选择未发生骨感染的骨折患者56例为非感染组。比较AOL组及各亚组与非感染组血清ESR、WBC、PCT及IL-6水平。分析AOL患者病情严重程度的影响因素。比较AOL不同预后患者的血清ESR、WBC、PCT及IL-6水平变化。分析血清ESR、WBC、PCT及IL-6水平单项及联合检测对AOL患者预后不良的预测价值。结果:AOL组血清ESR、WBC、PCT及IL-6水平显著高于非感染组(均P<0.05)。各亚组血清ESR、WBC、PCT及IL-6水平显著高于非感染组(均P<0.05)。多因素Logistic回归分析显示,血清ESR、WBC、PCT及IL-6水平是AOL患者病情严重程度的影响因素(均P<0.05)。103例患者中,预后良好81例,预后不良组22例,预后不良组血清ESR、WBC、PCT及IL-6水平显著高于预后良好组(均P<0.05)。受试者工作特征(ROC)曲线分析得出,血清ESR、WBC、PCT、IL-6水平单项及联合检测对AOL患者预后不良均具有一定的预测价值,且联合检测的预测价值更高。结论:血清ESR、WBC、PCT及IL-6参与AOL疾病的发生与发展,且水平随着疾病病情严重程度而变化,用于预测患者预后情况具有一定价值,而四项联合检测的预测价值更高。
Abstract:
Objective:To analyze the changes and significance of serum erythrocyte sedimentation rate(ESR),white blood cell(WBC),procalcitonin(PCT)and interleukin-6(IL-6)levels in patients with acute osteomyelitis(AOL).Methods:A total of 103 patients with AOL were selected as AOL group,and were divided into mild group(42 cases),moderate group(35 cases)and severe group(26 cases)according to the clinical severity.Another 56 fracture patients without bone infection were selected as the non-infection group.The serum levels of ESR,WBC,PCT and IL-6 in AOL group,each subgroup and non-infected group were compared.The influencing factors of the severity of AOL patients were analyzed.The changes of serum ESR,WBC,PCT and IL-6 levels in patients with different prognosis of AOL were compared.The predictive value of single and combined detection of serum ESR,WBC,PCT and IL-6 levels for poor prognosis in patients with AOL was analyzed.Results:The serum levels of ESR,WBC,PCT and IL-6 in the AOL group were significantly higher than those in the non-infection group(all P<0.05).The levels of serum ESR,WBC,PCT and IL-6 in each subgroup were significantly higher than those in the non-infection group(all P<0.05).Multivariate Logistic regression analysis showed that ESR,WBC,PCT and IL-6 levels were the influencing factors of the severity of AOL patients(all P<0.05).Among 103 patients,81 patients had good prognosis,and 22 patients had poor prognosis,and the levels of ESR,WBC,PCT and IL-6 in the poor prognosis group were significantly higher than those in the good prognosis group(all P<0.05).ROC curve analysis showed that serum ESR,WBC,PCT and IL-6 levels single and combined detection had certain predictive value for poor prognosis in patients with AOL,and the predictive value of combined detection was higher.Conclusion:Serum ESR,WBC,PCT and IL-6 are involved in the occurrence and development of AOL disease,and their levels change with the severity of the disease.They have certain value in predicting the prognosis of patients,and the combined detection of the four has a higher predictive value.

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备注/Memo

备注/Memo:
基金项目:四川省中医药管理局科研课题(2018LC027); 成都中医药大学 “吉林学者”医院专项课题(YYZX2019017)
更新日期/Last Update: 2023-06-05