[1]曹振振,韩会会,杨文义.肝癌患者血清成纤维细胞生长因子21和富亮氨酸α2糖蛋白1表达情况及临床意义[J].陕西医学杂志,2023,52(3):305-308,312.[doi:DOI:10.3969/j.issn.1000-7377.2023.03.013]
　CAO Zhenzhen,HAN Huihui,YANG Wenyi.Expression of FGF21 and LRG1 in serum of patients with hepatocellular carcinoma and its clinical diagnostic value[J].,2023,52(3):305-308,312.[doi:DOI:10.3969/j.issn.1000-7377.2023.03.013]
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肝癌患者血清成纤维细胞生长因子21和富亮氨酸α2糖蛋白1表达情况及临床意义
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《陕西医学杂志》[ISSN:1000-7377/CN:61-1281/TN]

卷:
52
期数:
2023年3期
页码:
305-308,312
栏目:
临床研究
出版日期:
2023-03-05

文章信息/Info

Title:
Expression of FGF21 and LRG1 in serum of patients with hepatocellular carcinoma and its clinical diagnostic value
作者:
曹振振1; 韩会会2; 杨文义1
(1.河南大学第一附属医院消化内科,河南 开封 475100; 2.河南大学第一附属医院心血管内科,河南 开封 475100)
Author(s):
CAO Zhenzhen; HAN Huihui; YANG Wenyi
(Department of Gastrointestinal Medicine,the First Affiliated Hospital of Henan University,Kaifeng 475100,China)
关键词:
肝癌;  成纤维细胞生长因子21;  富亮氨酸α2糖蛋白1;  诊断价值;  预后
Keywords:
Liver cancer;  Fibroblast growth factor 21;  Leucine-rich-alpha-2-glycoprotein 1;  Diagnostic value;  Prognosis
分类号:
R 735.7
DOI:
DOI:10.3969/j.issn.1000-7377.2023.03.013
文献标志码:
A
摘要:
目的:探讨肝癌患者血清成纤维细胞生长因子21(FGF21)和富亮氨酸α2糖蛋白1(LRG1)表达情况及临床意义。方法:选择肝癌患者84例为肝癌组,选择同期肝硬化患者88例为肝硬化组,选择同期健康体检者86例为对照组。采用酶联免疫吸附(ELISA)法检测血清FGF21、LRG1水平。采用生化分析仪检测肝功能指标[天冬氨酸氨基转移酶(AST)、谷氨酰转移酶(GGT)、丙氨酸氨基转移酶(ALT)、总胆汁酸(TBA)]水平。采用Pearson相关性分析肝癌患者血清FGF21、LRG1水平与肝功能指标的相关性。采用受试者工作特征(ROC)曲线分析血清FGF21、LRG1水平对肝癌的诊断价值。采用Cox回归分析影响肝癌预后的影响因素。结果:肝癌组血清FGF21、AST、GGT、ALT、TBA水平显著高于肝硬化组和对照组,LRG1水平显著低于肝硬化组和对照组(均P<0.05)。血清FGF21、LRG1水平及联合诊断肝癌的曲线下面积(AUC)分别为0.797、0.814、0.878,联合诊断AUC均高于单独诊断AUC(均P<0.05)。死亡组血清FGF21水平、有淋巴结转移患者比例显著高于生存组,血清LRG1水平低于生存组(均P<0.05)。高水平FGF21是肝癌患者死亡的独立危险因素(P<0.05),高水平LRG1是肝癌患者死亡的保护因素(P<0.05)。结论:肝癌患者血清FGF21水平升高,LRG1水平降低,两者在肝癌诊断中具有重要价值,且与患者预后密切相关。
Abstract:
Objective:To investigate the expression and clinical significance of serum fibroblast growth factor 21(FGF21)and leucine-rich-alpha-2-glycoprotein 1(LRG1)in patients with liver cancer.Methods:Eighty-four patients with liver cancer were taken as the liver cancer group,88 patients with liver cirrhosis in the same period were taken as the liver cirrhosis group,and 86 healthy people were taken as the control group.ELISA was used to detect the levels of serum FGF21 and LRG.Biochemical analyzer was used to detect the levels of AST,GGT,ALT and TBA.Pearson correlation was used to analyze the correlation between serum FGF21,LRG1 levels and liver function indicators in patients with liver cancer.ROC curve was drawn to analyze the diagnostic value of serum FGF21 and LRG1 levels for liver cancer.Cox regression was used to analyze the factors influencing the prognosis of liver cancer.Results:The serum levels of FGF21,AST,GGT,ALT and TBA in liver cancer group were obviously higher than those in liver cirrhosis group and control group,and the level of LRG1 was obviously lower than that in liver cirrhosis group and control group(all P<0.05).The AUC of levels of serum FGF21,LRG1,and combination in the diagnosis of liver cancer was 0.797,0.814 and 0.878 respectively,and the AUC of combined detection was higher than that of alone detection(P<0.05).The level of serum FGF21 and the proportion of patients with lymph node metastasis in the death group were obviously higher than those in the survival group,and the level of serum LRG1 was lower than that in the survival group(all P<0.05).High level of FGF21 was an independent risk factor for death of patients with liver cancer(P<0.05),the high level of LRG1 was a protective factor for the death of patients with liver cancer(P<0.05).Conclusion:The level of FGF21 in serum of patients with liver cancer is increased and the level of LRG1 is decreased.Both of them have important value in the diagnosis of liver cancer and are closely related to the prognosis of patients.

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备注/Memo

备注/Memo:
基金项目:河南省开封市科技发展计划项目(2207011)
更新日期/Last Update: 2023-03-06