[1]马 昕,纪 婷.血清可溶性细胞间黏附分子1和凝血指标检测对卵巢子宫内膜异位囊肿患者腹腔镜卵巢囊肿剔除术后复发的预测价值[J].陕西医学杂志,2023,52(2):208-211,216.[doi:DOI:10.3969/j.issn.1000-7377.2023.02.021]
　MA Xin,JI Ting.Predictive value of serum soluble intercellular adhesion molecule 1 and coagulation indexes for recurrence after laparoscopic ovarian cyst excision in patients with ovarian endometriosis[J].,2023,52(2):208-211,216.[doi:DOI:10.3969/j.issn.1000-7377.2023.02.021]
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血清可溶性细胞间黏附分子1和凝血指标检测对卵巢子宫内膜异位囊肿患者腹腔镜卵巢囊肿剔除术后复发的预测价值
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《陕西医学杂志》[ISSN:1000-7377/CN:61-1281/TN]

卷:
52
期数:
2023年2期
页码:
208-211,216
栏目:
临床检验
出版日期:
2023-02-05

文章信息/Info

Title:
Predictive value of serum soluble intercellular adhesion molecule 1 and coagulation indexes for recurrence after laparoscopic ovarian cyst excision in patients with ovarian endometriosis
作者:
马 昕; 纪 婷
(咸阳市中心医院医学检验科,陕西 咸阳 712000)
Author(s):
MA Xin; JI Ting
(Department of Medical Laboratory,Xianyang Central Hospital,Xianyang 712000,China)
关键词:
卵巢子宫内膜异位囊肿;  腹腔镜卵巢囊肿剔除术;  可溶性细胞间黏附分子1;  凝血指标;  复发;  预测效能
Keywords:
Ovarian endometriosis cyst;  Laparoscopic ovarian cyst excision;  Soluble intercellular adhesion molecule 1;  Coagulation index;  Relapse;  Predictive effectiveness
分类号:
R 711.59
DOI:
DOI:10.3969/j.issn.1000-7377.2023.02.021
文献标志码:
A
摘要:
目的:探讨血清可溶性细胞间黏附分子1(sICAM-1)和凝血指标检测对卵巢子宫内膜异位囊肿患者经腹腔镜卵巢囊肿剔除术后复发的预测效能。方法:选择行腹腔镜卵巢囊肿剔除术治疗的80例卵巢子宫内膜异位囊肿患者作为研究对象,根据术后3年内是否复发分为复发组(n=22)和未复发组(n=58)。采用酶联免疫吸附法检测两组患者血清sICAM-1水平,采用全自动血凝仪检测凝血酶原时间(PT)、凝血酶时间(TT)、活化部分凝血酶时间(APTT)、纤维蛋白原(FIB)、凝血酶原国际比值(INR)、血浆 D-二聚体(D-D)。分析两组各指标差异,采用受试者工作特征(ROC)曲线分析血清sICAM-1和凝血指标预测卵巢子宫内膜异位囊肿患者经腹腔镜卵巢囊肿剔除术后复发的效能。结果:80例患者术后3年内共有22例复发,复发率为27.50%。复发组患者术中探查囊肿直径显著大于未复发组(P<0.05)。复发组和未复发组患者术后1个月时血清sICAM-1水平均显著低于术前,复发组患者术前和术后1个月时血清sICAM-1水平均显著高于未复发组(均P<0.05)。复发组患者术前和术后1个月时的D-D水平显著高于未复发组(均P<0.05)。两组患者术后1个月时TT显著延长,FIB、D-D水平显著降低,未复发组术后1个月时PT显著缩短,与术前比较有统计学差异(均P<0.05)。ROC曲线结果显示sICAM-1、D-D水平预测术后3年内复发的AUC为0.796(95%CI:0.681～0.911)、0.761(95%CI:0.642～0.881)。结论:血清sICAM-1和D-D水平能够作为预测卵巢子宫内膜异位囊肿患者经腹腔镜卵巢囊肿剔除术后复发的生物标志物,sICAM-1预测效能优于D-D。
Abstract:
Objective:To investigate the efficacy of soluble intercellular adhesion molecule 1(sICAM-1)and coagulation indexes in predicting the recurrence of ovarian endometriosis cyst after laparoscopic ovarian cyst excision.Methods:A total of 80 patients with ovarian endometriosis cysts who were treated by laparoscopic ovarian cyst excision were selected as the study subjects.According to whether they relapsed within 3 years after surgery,they were divided into relapse group(22 cases)and non-relapse group(58 cases).The serum sICAM-1 level was detected by enzyme-linked immunosorbent assay,and prothrombin time(PT),thrombin time(TT),activated partial thrombin time(APTT),fibrinogen(FIB),international normalized ratio(INR),plasma D-Dimer(D-D)were detected by a fully automated hemagglutometer.The differences of various indexes in two groups were analyzed.Receiver operating characteristic(ROC)curve was used to analyze the efficacy of serum sICAM-1 and coagulation index in predicting the recurrence of ovarian endometriosis cyst in patients after laparoscopic ovarian cyst excision.Results:A total of 22 patients recurred within 3 years after operation,with a recurrence rate of 27.50%.The diameter of cysts in relapse group was significantly larger than that in the non- relapse group(P<0.05).The serum sICAM-1 level in the relapse group and the non-relapse group was significantly lower than that before operation,and the serum sICAM-1 level in the relapse group before and one month after operation was significantly higher than that in the non-relapse group(all P<0.05).The level of D-D in the relapse group before and one month after operation was significantly higher than that in the non-relapse group(P<0.05).TT was significantly prolonged and FIB and D-D levels were significantly decreased in the two groups one month after operation(P<0.05).PT was significantly shortened in the non-relapse group one month after operation,which was significantly different from that before operation(P<0.05).The ROC curve results showed that the AUC of sICAM-1 and D-D levels in predicting recurrence within 3 years after surgery was 0.796(95%CI:0.681 to 0.911),0.761(95%CI:0.642 to 0.881).Conclusion:Serum sICAM-1 and D-D levels can be used as biomarkers to predict the recurrence of patients with ovarian endometriosis cysts after laparoscopic ovarian cystectomy,and SICAM-1 is better than D-D.

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备注/Memo

备注/Memo:
基金项目:陕西省自然科学基础研究计划项目(2020JM-702)
更新日期/Last Update: 2023-02-06