[1]宋圆华,刘 霞,李 祯,等.血清脂蛋白相关磷脂酶A2、新饱食分子蛋白-1水平对2型糖尿病患者并发亚临床甲状腺功能减退症的预测价值[J].陕西医学杂志,2022,51(12):1593-1596.[doi:DOI:10.3969/j.issn.1000-7377.2022.12.030]
　SONG Yuanhua,LIU Xia,LI Zhen,et al.Predictive value of serum levels of Lp-PLA2 and Nesfatin-1 for T2DM patients complicated with subclinical hypothyroidism[J].,2022,51(12):1593-1596.[doi:DOI:10.3969/j.issn.1000-7377.2022.12.030]
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血清脂蛋白相关磷脂酶A2、新饱食分子蛋白-1水平对2型糖尿病患者并发亚临床甲状腺功能减退症的预测价值
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《陕西医学杂志》[ISSN:1000-7377/CN:61-1281/TN]

卷:
51
期数:
2022年12期
页码:
1593-1596
栏目:
临床检验
出版日期:
2022-12-05

文章信息/Info

Title:
Predictive value of serum levels of Lp-PLA2 and Nesfatin-1 for T2DM patients complicated with subclinical hypothyroidism
作者:
宋圆华; 刘 霞; 李 祯; 曹静雯; 张彦利; 鱼天英
(榆林市中医医院内分泌糖尿病科,陕西 榆林 719000)
Author(s):
SONG Yuanhua; LIU Xia; LI Zhen; CAO Jingwen; ZHANG Yanli; YU Tianying
(Department of Endocrinology and Diabetes,Yulin Hospital of Traditional Chinese Medicine,Yulin 719000,China)
关键词:
2型糖尿病;  亚临床甲状腺功能减退症;  脂蛋白相关磷脂酶A2;  新饱食分子蛋白-1;  预测价值
Keywords:
Type 2 diabetes mellitus;  Subclinical hypothyroidism;  Lipoprotein-associated phospholipase A2;  Nesfatin-1;  Predictive value
分类号:
R 587.1
DOI:
DOI:10.3969/j.issn.1000-7377.2022.12.030
文献标志码:
A
摘要:
目的:探讨血清脂蛋白相关磷脂酶A2(Lp-PLA2)、新饱食分子蛋白-1(Nesfatin-1)水平对2型糖尿病(T2DM)患者并发亚临床甲状腺功能减退症(亚临床甲减)的预测价值。方法:选取178例T2DM患者(研究组)和160例健康志愿者(对照组),检测并比较两组血清Lp-PLA2、Nesfatin-1水平。比较随访1年后并发与未并发亚临床甲减T2DM患者血清Lp-PLA2、Nesfatin-1水平。分析T2DM患者并发亚临床甲减的影响因素。分析血清Lp-PLA2、Nesfatin-1水平对T2DM患者并发亚临床甲减的预测价值。结果:研究组血清Lp-PLA2水平高于对照组,Nesfatin-1水平低于对照组(均P<0.05)。研究组随访1年内亚临床甲减发生率为17.16%,并发亚临床甲减T2DM患者血清Lp-PLA2水平高于未并发者,Nesfatin-1低于未并发者(均P<0.05)。Logistic多元回归分析表明,血清Lp-PLA2水平是T2DM患者并发亚临床甲减的独立危险因素,血清Nesfatin-1水平是其保护因素(均P<0.05)。ROC曲线分析显示,血清Lp-PLA2、Nesfatin-1水平联合预测T2DM患者并发亚临床甲减的灵敏度、AUC高于单项预测(均P<0.05),但特异度与单项预测比较差异无统计学意义(均P>0.05)。结论:T2DM患者血清Lp-PLA2水平偏高,Nesfatin-1水平偏低,两者均是T2DM患者并发亚临床甲减的影响因素,且两者联合对T2DM患者并发亚临床甲减的预测价值高。
Abstract:
Objective:To investigate the predictive value of serum levels of lipoprotein-associated phospholipase A2(Lp-PLA2)and Nesfatin-1 for T2DM patients complicated with subclinical hypothyroidism.Methods:Serum Lp-PLA2 and nesfatin-1 levels in 178 T2DM patients(study group)and 160 healthy volunteers(control group)were detected and compared.Serum Lp-PLA2 and Nesfatin-1 levels of T2DM patients with and without subclinical hypothyroidism were compared after 1 year of follow-up.The influencing factors of T2DM patients complicated with subclinical hypothyroidism were analyzed.The predictive value of serum Lp-PLA2 and Nesfatin-1 levels in T2DM patients complicated with subclinical hypothyroidism were analyzed.Results:The serum Lp-PLA2 level in the study group was higher than that in the control group,and the Nesfatin-1 level was lower than that in the control group(all P<0.05).The incidence rate of subclinical hypothyroidism in the study group was 17.16% within 1 year of follow-up.The serum Lp-PLA2 level of T2DM patients complicated with subclinical hypothyroidism was higher than that of non-complicated patients,and Nesfatin-1 level was lower than that of non-complicated patients(all P<0.05).Logistic regression analysis showed that serum Lp-PLA2 level was an independent risk factor for T2DM patients complicated with subclinical hypothyroidism,and serum Nesfatin-1 level was a protective factor(all P<0.05).ROC curve analysis showed that the sensitivity and AUC of combined prediction of serum Lp-PLA2 and Nesfatin-1 in predicting T2DM patients complicated with subclinical hypothyroidism were higher than those in single prediction(all P<0.05),but there was no significant difference in specificity between combined prediction and single prediction(all P>0.05).Conclusion:The serum Lp-PLA2 level of T2DM patients is high and the Nesfatin-1 level is low,both of which are the influencing factors of T2DM patients complicated with subclinical hypothyroidism,and the combination of both has high predictive value for T2DM patients complicated with subclinical hypothyroidism.

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备注/Memo

备注/Memo:
基金项目:陕西省榆林市科技计划项目(SF18-005)
更新日期/Last Update: 2022-12-05