[1]韩佩佩,屈可伸,杨 春,等.外用碱性成纤维细胞生长因子凝胶联合超脉冲CO2点阵激光治疗痤疮瘢痕疗效观察[J].陕西医学杂志,2022,51(12):1577-1580.[doi:DOI:10.3969/j.issn.1000-7377.2022.12.026]
　HAN Peipei,QU Keshen,YANG Chun,et al.Curative effect of topical basic fibroblast growth factor gel combined with ultra-pulsed CO2 fractional laser in treatment of acne scars[J].,2022,51(12):1577-1580.[doi:DOI:10.3969/j.issn.1000-7377.2022.12.026]
点击复制

外用碱性成纤维细胞生长因子凝胶联合超脉冲CO2点阵激光治疗痤疮瘢痕疗效观察
分享到：

《陕西医学杂志》[ISSN:1000-7377/CN:61-1281/TN]

卷:
51
期数:
2022年12期
页码:
1577-1580
栏目:
药物与临床
出版日期:
2022-12-05

文章信息/Info

Title:
Curative effect of topical basic fibroblast growth factor gel combined with ultra-pulsed CO2 fractional laser in treatment of acne scars
作者:
韩佩佩; 屈可伸; 杨 春; 王 维; 王玉珍; 舒逸青; 张平安
(陕西中医药大学第二附属医院皮肤整形科,陕西 咸阳 712046)
Author(s):
HAN Peipei; QU Keshen; YANG Chun; WANG Wei; WANG Yuzhen; SHU Yiqing; ZHANG Ping'an
(Department of Dermatology,the Second Affiliated Hospital,Shaanxi University of Chinese Medicine,Xianyang 712046,China)
关键词:
痤疮瘢痕;  超脉冲CO2点阵激光;  碱性成纤维细胞生长因子凝胶;  基底深度;  痤疮瘢痕权重评分
Keywords:
Acne scars;  Ultra-pulsed CO2 fractional laser;  Basic fibroblast growth factor gel;  Base depth;  ECCA
分类号:
R 758.733
DOI:
DOI:10.3969/j.issn.1000-7377.2022.12.026
文献标志码:
A
摘要:
目的:探讨外用碱性成纤维细胞生长因子(bFGF)凝胶对超脉冲CO2点阵激光治疗痤疮瘢痕的疗效。方法:选取痤疮瘢痕患者100例为研究对象,随机分为对照组(50例)和研究组(50例)。对照组行超脉冲CO2点阵激光治疗,外用莫匹罗星软膏。研究组在对照组治疗基础上外用bFGF凝胶。观察两组临床疗效。对比两组患者治疗后痤疮基底深度、痤疮瘢痕权重(ECCA)评分、结痂时间及红斑持续时间。结果:研究组治疗总有效率较对照组高(P<0.05)。治疗前,两组痤疮基底深度和ECCA评分比较差异无统计学意义(均P>0.05)。治疗1、3个月后,研究组痤疮基底深度和ECCA评分较对照组低(均P<0.05)。研究组结痂时间和红斑持续时间较对照组短(均P<0.05)。结论:外用bFGF凝胶联合超脉冲CO2点阵激光治疗痤疮瘢痕,可明显改善痤疮基底深度和ECCA评分,缩短结痂时间及红斑持续时间。
Abstract:
Objective:To investigate the curative effect of topical basic fibroblast growth factor(bFGF)gel combined with ultra-pulsed CO2 fractional laser in the treatment of acne scars.Methods:A total of 100 patients with acne scars were selected as the research objects.They were divided into control group(50 cases)and research group(50 cases).The control group received ultra-pulsed CO2 fractional laser treatment and externally applied mupirocin ointment.The study group received topical bFGF gel based on the treatment of the control group.The clinical effects of the two groups were observed.Acne basal depth,ECCA score,crusting time and erythema duration were compared between the two groups.Results:The total effective rate of treatment in the study group was higher than that in the control group(P<0.05).Before treatment,there was no significant difference in acne base depth and skin barrier and ECCA score between the two groups(all P>0.05).After 1 and 3 months of treatment,the acne base depth,ECCA score in the study group were lower than those in the control group(all P<0.05).The crusting time and erythema duration in the study group were shorter than those in the control group(all P<0.05).Conclusion:Topical bFGF gel combined with ultra-pulsed CO2 fractional laser can significantly improve acne basal depth,ECCA score,and shorten crusting time and erythema duration.

参考文献/References:

[1] 陈 玮.超脉冲二氧化碳点阵激光联合果酸换肤治疗痤疮瘢痕的疗效[J].特别健康,2020,3(3):89.
[2] 彭 曦,熊 维,黄海艳,等.脉冲染料激光联合二氧化碳点阵激光对兔耳增生性瘢痕的影响[J].中国麻风皮肤病杂志,2020,36(5):262-266.
[3] 江 波,唐 瑞,郑丹玉,等.超脉冲二氧化碳点阵激光清创术在慢性创面治疗中的临床效果[J].中华烧伤杂志,2020,36(4):273-279.
[4] 古琴妹,杨 杨,齐向东.外用细胞生长因子应用于激光治疗面部老化及瘢痕术后的疗效观察[J].中国美容整形外科杂志,2020,31(2):92-95.
[5] 崖 骞,杨韩芳,王婵娟,等.复发性瘢痕疙瘩手术切除减张缝合联合电子线照射的临床疗效观察[J].中华整形外科杂志,2022,38(1):74-77.
[6] 刘孝兵,宋印娥,杨 帆,等.超脉冲CO2点阵激光与微针治疗面部痤疮凹陷性瘢痕的疗效对比[J].中国中西医结合皮肤性病学杂志,2017,16(4):315-317.
[7] 中华医学会医学美学与美容学分会激光美容学组,中华医学会皮肤性病学分会美容激光学组,中国医师协会美容与整形医师分会激光学组.中国痤疮瘢痕治疗专家共识(2021)[J].中华皮肤科杂志,2021,54(9):747-756.
[8] Manstein D,Herron GS,Sink RK,et al.Fractional photothermolysis:A new concept for cutaneous remodeling using microscopic pattems of thermal injury[J].Lasers Surg Med,2004,34(5):426-438.
[9] 邓红柳,冯 倩.SVF-gel与超脉冲CO2点阵激光治疗凹陷性痤疮瘢痕的对比研究[J].检验医学与临床,2021,18(2):249-251.
[10] Xu H,Zhang S,Zhang A.Effect of ultra-pulsed CO2 laser combined with micro-needle therapy on depressed scars of acne[J].China Medical Cosmetology,2018,8(5):54-56.
[11] 吴红巾,周炳荣,骆 丹.点阵激光辅助局部用药的研究进展[J].国际皮肤性病学杂志,2015,41(3):153-155.
[12] 薛燕宁,徐 萍,李 峰,等.CO2点阵激光联合胶原贴敷料治疗面部痤疮凹陷性瘢痕的临床观察[J].中华皮肤科杂志,2015,48(3):193-194.
[13] 宋 婷,罗 莉,贾 菲,等.1540 nm非剥脱性点阵激光联合水凝胶医用冷敷贴治疗凹陷性痤疮瘢痕疗效研究[J].陕西医学杂志,2019,48(2):241-243.
[14] 程 静,李 娜,杨 丽,等.增生性瘢痕形成不同时期二氧化碳点阵激光治疗的效果分析[J].第三军医大学学报,2021,43(11):1032-1038.
[15] 黄 振,陈 烨,王 朋,等.二氧化碳点阵激光联合自体脂肪注射治疗烧伤后增生性瘢痕效果的前瞻性平行对照临床研究[J].中华烧伤杂志,2020,37(1):21.
[16] 唐卫平,胡 琦,陈国栋,等.碱性成纤维细胞生长因子处理对脂肪间充质干细胞治疗肝硬化疗效的影响[J].中华肝脏病杂志,2020,28(12):1030-1035.
[17] 张 翠,李海燕,朱超华.液氮低温冷冻与局麻下CO2激光联合外用干扰素凝胶治疗女性外阴尖锐湿疣的效果比较[J].河北医药,2021,43(11):1710-1713.
[18] 李树松,马 滢,吴晓明,等.胸腺素β4联合外源性bFGF对深Ⅱ度烫伤大鼠创面愈合的影响及机制研究[J].西部医学,2020,32(2):203-209.
[19] 武凤莲,朱东来,王连英,等.A型肉毒毒素对增生性瘢痕组织中bFGF、caspase-3和Bcl-2表达的影响[J].河北医药,2020,42(4):499-502,507.
[20] 韦林宜,蒋 丽.二氧化碳点阵激光对阴道松弛患者盆底肌松弛、性生活质量及阴道黏膜相关指标的影响[J].中国性科学,2020,29(6):83-86.
[21] 吴晓玉,李成茂,王灿林.软性接触镜和rb-bFGF滴眼液对角膜深层异物剔除术后促修复的疗效比较[J].国际眼科杂志,2020,20(2):332-335.
[22] 钟 志,刘 伟,邓红柳.局灶点阵激光联合他扎罗汀治疗痤疮凹陷性瘢痕31例临床研究[J].陕西医学杂志,2020,49(7):818-820.

备注/Memo

备注/Memo:
基金项目:陕西省重点研发计划项目(2021SF-408)
更新日期/Last Update: 2022-12-05