[1]康 锋,代凤霞.乳腺癌组织中孕激素受体、人表皮生长因子受体-2检测联合动态增强磁共振成像对乳腺癌术后复发时间的预测价值[J].陕西医学杂志,2022,51(11):1437-1440,1452.[doi:DOI:10.3969/j.issn.1000-7377.2022.11.028]
　KANG Feng,DAI Fengxia.Predictive value of detection of PR and HER-2 in breast cancer tissue combined with dynamic contrast-enhanced MRI for recurrence time after breast cancer surgery[J].,2022,51(11):1437-1440,1452.[doi:DOI:10.3969/j.issn.1000-7377.2022.11.028]
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乳腺癌组织中孕激素受体、人表皮生长因子受体-2检测联合动态增强磁共振成像对乳腺癌术后复发时间的预测价值
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《陕西医学杂志》[ISSN:1000-7377/CN:61-1281/TN]

卷:
51
期数:
2022年11期
页码:
1437-1440,1452
栏目:
临床检验
出版日期:
2022-11-05

文章信息/Info

Title:
Predictive value of detection of PR and HER-2 in breast cancer tissue combined with dynamic contrast-enhanced MRI for recurrence time after breast cancer surgery
作者:
康 锋1; 代凤霞2
(1.渭南市妇幼保健院外一科,陕西 渭南 714099; 2.商洛国际医学中心医院CT室,陕西 商洛 726099)
Author(s):
KANG Feng; DAI Fengxia
(First Department of Surgery,Weinan Maternal and Child Health Hospital,Weinan 714099,China)
关键词:
乳腺癌;  复发时间;  动态增强磁共振成像;  孕激素受体;  人表皮生长因子受体-2;  预测价值
Keywords:
Breast cancer;  Recurrence time;  Dynamic contrast-enhanced MRI;  Progesterone receptor;  Human epidermal growth factor receptor-2;  Predictive value
分类号:
R 737.9
DOI:
DOI:10.3969/j.issn.1000-7377.2022.11.028
文献标志码:
A
摘要:
目的:探究乳腺癌组织中孕激素受体(PR)、人表皮生长因子受体-2(HER-2)检测联合动态增强磁共振成像(DCE-MRI)对乳腺癌术后复发时间的预测价值。方法:回顾性分析接受乳腺癌根治术的280例原发性乳腺癌患者的临床资料,其中68例(24.29%)发生复发,早期复发患者28例(41.18%),晚期复发患者40例(58.82%)。所有患者均在术前行DCE-MRI检查,并检测乳腺癌组织中PR和HER-2的表达。收集所有患者的临床资料,应用受试者工作特征曲线(ROC)判定各指标单项检测和联合检测的预测效能。结果:早期复发和晚期复发患者在淋巴结转移数上相比有统计学差异(均P<0.05),而在年龄、体重指数(BMI)、月经状况、病理分型、亚型、组织学分级方面比较无统计学差异(均P>0.05)。两组患者在Ktrans上相比有统计学差异(P<0.05),而在Kep和Vp上相比无统计学差异(均P>0.05)。早期复发组和晚期复发组患者乳腺癌组织中PR和HER-2的表达比较有统计学差异(均P<0.05)。Ktrans、PR、HER-2单项检测及三项联合检测预测乳腺癌术后复发的ROC曲线下面积为0.613、0.722、0.727、0.889。结论:DCE-MRI参数及PR、HER-2的表达可作为乳腺癌根治术后复发时间的重要预测指标,且三者联合检测对复发时间预测效能更高,可为临床及早干预、改善患者预后和生存质量提供重要的参考。
Abstract:
Objective:To investigate the predictive value of detection of progesterone receptor(PR)and human epidermal growth factor receptor-2(HER-2)in breast cancer tissue combined with dynamic contrast-enhanced MRI(DCE-MRI)for recurrence time after breast cancer surgery.Methods:A total of 280 breast cancer patients underwent radical mastectomy were collected as research subjects,and 68 cases(24.29%)were recur,28 cases(41.18%)were early recurrence and 40 cases(58.82%)were late recurrence.All patients were conducted DCE-MRI preoperative,the expressions of PR and HER-2 were detected.All clinical data were collected,and ROC curve was used to determine the predictive efficiency of single and combined detection for each index.Results:The number of lymph nodes metastasis of early recurrence and late recurrence were significantly different(P<0.05),while the age,BMI,menstrual status,pathological type,subtype,histological grade of two groups had no significant difference(all P>0.05).The Ktransof two groups were significantly different(P<0.05),while the Kep and Vp had no significant difference(all P>0.05).The expression of PR and HER-2 of two groups were significantly different(all P<0.05).The area under the ROC curve of Ktrans, PR,HER-2 single detection and combined detection for predicting postoperative recurrence of breast cancer was 0.613,0.722,0.727,0.889.Conclusion:The DCE-MRI and PR,HER-2 can be important factors in predicting recurrence time of breast cancer postoperative,and combined detection of three indexes had higher predictive value,which can provide important theoretical reference for early intervention and improvement of prognosis and quality of life.

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备注/Memo

备注/Memo:
基金项目:陕西省卫生健康科研基金资助项目(2018C007)
更新日期/Last Update: 2022-11-09