[1]王建锋,贺青文,范秀芳,等.血清抗载脂蛋白A1抗体、抗C末端apoA-1抗体水平与先兆流产相关性研究[J].陕西医学杂志,2022,51(11):1368-1371.[doi:DOI:10.3969/j.issn.1000-7377.2022.11.011]
　WANG Jianfeng,HE Qingwen,FAN Xiufang,et al.Correlation between serum anti-apolipoprotein A1 antibody,anti-C-terminal apoA-1 antibody and threatened abortion[J].,2022,51(11):1368-1371.[doi:DOI:10.3969/j.issn.1000-7377.2022.11.011]
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血清抗载脂蛋白A1抗体、抗C末端apoA-1抗体水平与先兆流产相关性研究
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《陕西医学杂志》[ISSN:1000-7377/CN:61-1281/TN]

卷:
51
期数:
2022年11期
页码:
1368-1371
栏目:
临床研究
出版日期:
2022-11-05

文章信息/Info

Title:
Correlation between serum anti-apolipoprotein A1 antibody,anti-C-terminal apoA-1 antibody and threatened abortion
作者:
王建锋; 贺青文; 范秀芳; 李江鹏
(西安市人民医院 西安市第四医院妇产科,陕西 西安 710004)
Author(s):
WANG Jianfeng; HE Qingwen; FAN Xiufang; LI Jiangpeng
(Department of Obstetrics and Gynecology,Xi'an People's Hospital,Xi'an 710004,China)
关键词:
抗载脂蛋白A-1;  自身抗体阳性;  先兆流产;  自身免疫疾病;  相关性;  预测
Keywords:
Anti-apolipoprotein A-1;  Positive autoantibodies;  Threatened abortion;  Autoimmune diseases;  Correlation;  Predict
分类号:
R 714.21
DOI:
DOI:10.3969/j.issn.1000-7377.2022.11.011
文献标志码:
A
摘要:
目的:探讨血清抗载脂蛋白A1抗体(ApoA-1 IgG)与抗C末端apoA-1抗体(Ac-terAA1 IgG)水平与先兆流产的相关性。方法:选取371例孕妇作为研究对象,并对所有对象进行跟踪随访,直到孕妇分娩为止。根据有无先兆流产分为有先兆流产组(31例),无先兆流产组(340例)。应用酶联免疫吸附法测定两组血清抗ApoA-1、抗Ac-terAA1 IgG水平。采用Pearson相关性分析抗ApoA-1 IgG和抗Ac-terAA1 IgG水平与先兆流产的相关性。采用受试者工作特征曲线(ROC)分析抗ApoA-1 IgG和抗Ac-terAA1 IgG与先兆流产的关系。结果:①有先兆流产组和无流产先兆组孕妇年龄、体重指数(BMI)、分娩时体重增加、C反应蛋白(CRP)以及合并症对比无统计学差异(均P>0.05),抗ApoA-1 IgG和抗Ac-terAA1 IgG水平对比有统计学差异(P<0.05)。②经Pearson相关性分析,血清抗ApoA-1 IgG和抗Ac-terAA1 IgG水平与先兆流产之间存在正相关(P<0.05)。③经ROC曲线分析表明:妊娠期血清抗ApoA-1 IgG(OR=2.546,95% CI:1.364～3.475)、抗Ac-terAA1 IgG(OR=2.458,95% CI:1.359～3.257)水平对先兆流产的预后有预测价值(P<0.05)。结论:先兆流产患者血清抗ApoA-1、抗Ac-terAA1 IgG水平升高,可作为预测孕妇先兆流产的标志物,但其具体的生物学机制还需进一步深入研究。
Abstract:
Objective:To investigate the correlation between anti-apolipoprotein A-1(ApoA-1),anti-C-terminal apoA-1(Ac-terAA1)and threatened abortion.Methods:A total of 371 pregnant women were selected as the research subjects,and all subjects were followed up until the pregnant women gave birth.According to the presence or absence of threatened abortion,the patients were divided into threatened abortion group(31 cases)and non-abortive threatened group(340 cases).The serum anti-ApoA-1 and anti-Ac-terAA1 IgG levels of the two groups were determined by enzyme-linked immunosorbent assay.Pearson correlation was used to analyze the association of anti-ApoA-1 IgG and anti-Ac-terAA1 IgG levels with threatened abortion.ROC curve was used to analyze the relationship between anti-ApoA-1 IgG,anti-Ac-terAA1 IgG and threatened abortion.Results:There were no significant differences in maternal age,BMI,weight gain at delivery,CRP,and comorbidities between the two groups(all P>0.05).The levels of anti-ApoA-1 IgG and anti-Ac-terAA1 IgG were statistically different(P<0.05).Pearson correlation analysis showed that there was a positive correlation between serum anti-ApoA-1 IgG,anti-Ac-terAA1 IgG levels and threatened abortion(all P<0.05).The ROC curve analysis showed that the serum levels of anti-ApoA-1 IgG(OR=2.546,95%CI:1.364 to 3.475)and anti-Ac-terAA1 IgG(OR=2.458,95%CI:1.359 to 3.257)during pregnancy were predictive of the prognosis of threatened abortion(P<0.05).Conclusion:Serum anti-ApoA-1 and anti-Ac-terAA1 IgG levels in patients with threatened abortion are elevated,which can be used as markers for predicting threatened abortion in pregnant women,but the specific biological mechanism needs to be further studied.

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备注/Memo

备注/Memo:
基金项目:西安市科技计划项目[2019115513YX010SF043(6)]
更新日期/Last Update: 2022-11-09