[1]宋 炜,徐晓军,张学平.C1q坏死因子相关蛋白12、脂联素在脑动脉粥样硬化大鼠血清中的表达及其与磁共振成像技术参数相关性研究[J].陕西医学杂志,2022,51(11):1341-1345.[doi:DOI:10.3969/j.issn.1000-7377.2022.11.005]
　SONG Wei,XU Xiaojun,ZHANG Xueping.Expression of C1q necrosis factor-related protein 12 and adiponectin in cerebral atherosclerotic rats and their correlation with technical parameters of MRI[J].,2022,51(11):1341-1345.[doi:DOI:10.3969/j.issn.1000-7377.2022.11.005]
点击复制

C1q坏死因子相关蛋白12、脂联素在脑动脉粥样硬化大鼠血清中的表达及其与磁共振成像技术参数相关性研究
分享到：

《陕西医学杂志》[ISSN:1000-7377/CN:61-1281/TN]

卷:
51
期数:
2022年11期
页码:
1341-1345
栏目:
基础研究
出版日期:
2022-11-05

文章信息/Info

Title:
Expression of C1q necrosis factor-related protein 12 and adiponectin in cerebral atherosclerotic rats and their correlation with technical parameters of MRI
作者:
宋 炜1; 徐晓军1; 张学平2
(1.陕西省康复医院影像科,陕西 西安 710065; 2.榆林市星元医院磁共振室,陕西 榆林 719000)
Author(s):
SONG Wei; XU Xiaojun; ZHANG Xueping
(Department of Imaging,Shaanxi Provincial Rehabilitation Hospital,Xi'an 710065,China)
关键词:
C1q坏死因子相关蛋白12;  脂联素;  脑动脉粥样硬化;  磁共振成像;  脑动脉斑块个数;  厚度;  体积
Keywords:
C1q necrosis factor-related protein 12;  Adiponectin;  Intracranial atherosclerosis;  Magnetic resonance imaging;  Number of cerebral artery plaque;  Thickness;  Volume
分类号:
R 743.1
DOI:
DOI:10.3969/j.issn.1000-7377.2022.11.005
文献标志码:
A
摘要:
目的:研究脑动脉粥样硬化大鼠血清C1q坏死因子相关蛋白12(CTRP12)和脂联素(APN)的表达水平,及其与磁共振成像技术参数的相关性。方法:30只SD大鼠随机分为两组,即对照组(假手术健康大鼠)和模型组(脑动脉粥样硬化大鼠)。检测并比较两组大鼠收缩压、血清总胆固醇、甘油三酯、低密度脂蛋白胆固醇、CTRP12以及APN水平。使用小动物磁共振成像仪检测模型组大鼠脑动脉斑块个数、厚度以及体积,并使用Pearson法分析血清CTRP12、APN与脑动脉斑块个数、厚度、体积的相关性。结果:模型组大鼠收缩压和血清总胆固醇、甘油三酯、低密度脂蛋白胆固醇水平均显著高于对照组正常大鼠(均P<0.05)。模型组大鼠血清CTRP12和APN水平均显著低于对照组正常大鼠(均P<0.05)。模型组大鼠血清CTRP12与脑动脉斑块个数(r=-0.732,P<0.05)、厚度(r=-0.622,P<0.05)、体积(r=-0.732,P<0.05)均呈负相关; 模型组大鼠血清APN与脑动脉斑块个数(r=-0.692,P<0.05)、厚度(r=-0.577,P<0.05)、体积(r=-0.612,P<0.05)均呈负相关。结论:脑动脉粥样硬化大鼠血清CTRP12和APN的表达水平降低,并且其与磁共振成像检测的脑动脉斑块个数、厚度和体积均呈负相关。
Abstract:
Objective:To study the expression levels of serum C1q necrosis factor-related protein 12(CTRP12)and adiponectin(APN)in cerebral atherosclerotic rats and their correlation with technical parameters of MRI.Methods:Thirty SD rats were randomly divided into control group(sham-operated healthy rats)and model group(cerebral atherosclerotic rats).The levels of systolic blood pressure,serum total cholesterol,triglyceride,low-density lipoprotein cholesterol,CTRP12 and APN were detected and compared between two groups.The number,thickness and volume of cerebral artery plaques in the model group were detected by a small animal magnetic resonance imaging device.Pearson method was used to analyze the correlation between serum CTRP12,APN and the number,thickness and volume of cerebral artery plaques.Results:The systolic blood pressure,serum total cholesterol,triglyceride and low-density lipoprotein cholesterol levels of model group were significantly higher than those of control group(all P<0.05).The serum CTRP12 and APN levels in model group were significantly lower than those in control group(all P<0.05).In the model group,serum CTRP12 was negatively correlated with the number,thickness and volume of cerebral artery plaques(r=-0.732,-0.622,-0.732,all P<0.05),and serum APN was also negatively correlated with the number,thickness and volume of cerebral artery plaques(r=-0.692,-0.577,-0.612,all P<0.05).Conclusion:Serum CTRP12 and APN expression levels were decreased in rats with intracranial atherosclerosis,and they were negatively correlated with the number,thickness and volume of cerebral arterial plaques detected by MRI.

参考文献/References:

[1] 南武娟,文申英.急性冠脉综合征大鼠外周血巨噬细胞中脂质稳态与动脉粥样硬化指数相关性研究[J].陕西医学杂志,2022,51(4):401-405.
[2] Lechner K,Schacky C,Kenzie AL,et al.Lifestyle factors and high-risk atherosclerosis:Pathways and mechanisms beyond traditional risk factors [J].Eur J Prev Cardiol,2020,27(4):394-406.
[3] Ma Q,Li R,Wang L,et al.Temporal trend and attributable risk factors of stroke burden in China,1990-2019:An analysis for the global burden of disease study 2019[J].Lancet Public Health,2021,6(12):897-906.
[4] 师 媛,王晓娟.短暂性脑缺血发作患者颈动脉狭窄程度与颈动脉斑块易损性关系及对近期缺血性脑卒中的预测价值研究[J].陕西医学杂志,2022,51(4):454-457,496.
[5] Calcagno C,Pérez-Medina C,Mulder WJM,et al.Whole-body atherosclerosis imaging by positron emission tomography/magnetic resonance imaging:From mice to nonhuman primates[J].Arterioscler Thromb Vasc Biol,2020,40(5):1123-1134.
[6] Tan SY,Little HC,Sarver DC,et al.CTRP12 inhibits triglyceride synthesis and export in hepatocytes by suppressing HNF-4α and DGAT2 expression[J].FEBS Lett,2020,594(19):3227-3239.
[7] Wang G,Chen JJ,Deng WY,et al.CTRP12 ameliorates atherosclerosis by promoting cholesterol efflux and inhibiting inflammatory response via the miR-155-5p/LXRα pathway[J].Cell Death & Disease,2021,12(3):1-15.
[8] 宋金玉,杜 鑫,施继红,等.芪苈强心胶囊联合米力农对心肌梗死合并心力衰竭患者动脉血流和心功能的影响[J].陕西中医,2020,41(4):493-495.
[9] 朱岩岩,李 彤,李合华,等.高血压合并高血脂建立脑动脉粥样硬化大鼠模型的实验研究[J].中华脑科疾病与康复杂志:电子版,2014,12(2):31-34.
[10] Agouni A,Parray AS,Akhtar N,et al.There is selective increase in pro-thrombotic circulating extracellular vesicles in acute ischemic stroke and transient ischemic attack:A study of patients from the middle east and southeast Asia[J].Front Neurol,2019,10(19):251.
[11] 魏东生,邵 卫,张忠文,等.归脾汤联合复方银杏通脉口服液治疗老年脑动脉粥样硬化临床研究[J].陕西中医,2017,38(8):1106-1107.
[12] Widjaja KK,Chulavatnatol S,Suansanae T,et al.Knowledge of stroke and medication adherence among patients with recurrent stroke or transient ischemic attack in Indonesia:A multi-center,cross-sectional study[J].International Journal of Clinical Pharmacy,2021,43(3):666-672.
[13] Henning RJ.Obesity and obesity-induced inflammatory disease contribute to atherosclerosis:A review of the pathophysiology and treatment of obesity[J].Am J Cardiovasc Dis,2021,11(4):504-529.
[14] Yanai H,Yoshida H.Beneficial effects of adiponectin on glucose and lipid metabolism and atherosclerotic progression:Mechanisms and perspectives[J].Int J Mol Sci,2019,20(5):1190.
[15] Fadaei R,Moradi N,Kazemi T,et al.Decreased serum levels of CTRP12/adipolin in patients with coronary artery disease in relation to inflammatory cytokines and insulin resistance[J].Cytokine,2019,113(1):326-331.
[16] Tan SY,Lei X,Little HC,et al.CTRP12 ablation differentially affects energy expenditure,body weight,and insulin sensitivity in male and female mice[J].Am J Physiol Endocrinol Metab,2020,319(1):e146-e162.
[17] Yedavalli V,DiGiacomo P,Tong E,et al.High-resolution structural magnetic resonance imaging and quantitative susceptibility mapping[J].Magn Reson Imaging Clin N Am,2021,29(1):13-39.
[18] Zhao JJ,Lu Y,Cui JY,et al.Characteristics of symptomatic plaque on high-resolution magnetic resonance imaging and its relationship with the occurrence and recurrence of ischemic stroke[J].Neurol Sci,2021,42(9):3605-3613.
[19] Vranic JE,Hartman JB,Mossa-Basha M.High-resolution magnetic resonance vessel wall imaging for the evaluation of intracranial vascular pathology[J].Neuroimaging Clin N Am,2021,31(2):223-233.
[20] 卢 静,易兴阳,李 洁,等.炎症和内皮功能相关基因多态性与颈动脉斑块相关性研究[J].中华神经科杂志,2020,53(10):763-771.

相似文献/References:

[1]冯克娜,张 淼,陈雅静.2型糖尿病患者血清C1q肿瘤坏死因子相关蛋白5、脂联素水平与颈动脉粥样硬化关系研究[J].陕西医学杂志,2024,(3):357.[doi:DOI:10.3969/j.issn.1000-7377.2024.03.015]
　FENG Kena,ZHANG Miao,CHEN Yajing.Relationship between serum CTRP5,APN levels and carotid atherosclerosis in T2DM patients[J].,2024,(11):357.[doi:DOI:10.3969/j.issn.1000-7377.2024.03.015]
[2]蔡敏一,赵德强,于宏梅,等.老年冠心病患者血清脂联素、生长素释放肽水平与血小板聚集率及主要不良心脏事件相关性分析[J].陕西医学杂志,2024,(7):931.[doi:DOI:10.3969/j.issn.1000-7377.2024.07.014]
　CAI Minyi,ZHAO Deqiang,YU Hongmei,et al.Correlation analysis of serum APN and Ghrelin levels with platelet aggregation rate and major adverse cardiac events in elderly patients with coronary heart disease[J].,2024,(11):931.[doi:DOI:10.3969/j.issn.1000-7377.2024.07.014]
[3]王 坤,张宸豪,荣萌萌,等.阿尔茨海默病患者血清三磷酸腺苷结合盒转运蛋白7、基质金属蛋白酶9、脂联素水平与认知功能相关性分析[J].陕西医学杂志,2024,(10):1387.[doi:DOI:10.3969/j.issn.1000-7377.2024.10.019]
　WANG Kun,ZHANG Chenhao,RONG Mengmeng,et al.Correlation between serum ABCA7,MMP-9,ADPN levels and cognitive function in patients with Alzheimer's disease[J].,2024,(11):1387.[doi:DOI:10.3969/j.issn.1000-7377.2024.10.019]

备注/Memo

备注/Memo:
基金项目:陕西省重点研发计划项目(2021SF-252)
更新日期/Last Update: 2022-11-09