[1]徐 慧,秦静静,张 曹,等.血浆D-二聚体水平与胃癌患者预后关系Meta分析[J].陕西医学杂志,2022,51(9):1158-1162.[doi:DOI:10.3969/j.issn.1000-7377.2022.09.027]
　XU Hui,QIN Jingjing,ZHANG Cao,et al.Meta-analysis of the relationship between plasma D-dimer level and prognosis of gastric cancer patients[J].,2022,51(9):1158-1162.[doi:DOI:10.3969/j.issn.1000-7377.2022.09.027]
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血浆D-二聚体水平与胃癌患者预后关系Meta分析
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《陕西医学杂志》[ISSN:1000-7377/CN:61-1281/TN]

卷:
51
期数:
2022年9期
页码:
1158-1162
栏目:
Meta分析
出版日期:
2022-09-05

文章信息/Info

Title:
Meta-analysis of the relationship between plasma D-dimer level and prognosis of gastric cancer patients
作者:
徐 慧1; 秦静静1; 张 曹1; 2; 柳涛涛1; 李 昊1; 谢昌奇1
(1.宁夏医科大学,宁夏 银川 750004; 2.宁夏医科大学总医院胃肠外科,宁夏 银川 750004)
Author(s):
XU Hui; QIN Jingjing; ZHANG Cao; LIU Taotao; LI Hao; XIE Changqi
(Ningxia Medical University,Yinchuan 750004,China)
关键词:
胃癌;  血浆D-二聚体;  预后;  总生存时间;  无复发生存时间;  无病生存时间
Keywords:
Gastric cancer;  Plasma D-dimer;  Prognosis;  Overall survival;  Recurrence free survival;  Disease-free survival
分类号:
R 735.2
DOI:
DOI:10.3969/j.issn.1000-7377.2022.09.027
文献标志码:
A
摘要:
目的:分析血浆D-二聚体与胃癌患者预后的关系。方法:通过计算机检索PubMed文献数据库、根哥学术(Geen Medical)、考克兰图书馆(Cochrane Library)、万方数据知识服务平台(Wanfang Data)、中国知网(CNKI)等国内外数据库中所有探讨血浆D-二聚体与胃癌患者预后关系的文献,检索时间为建库至2021年12月31日。采用Rev Man 5.4统计学软件进行分析,使用具有95%置信区间(CI)的风险比(HR)来评估血浆D-二聚体与胃癌患者总生存时间(OS)、无病生存时间(DFS)或无复发生存时间(RFS)的关系。结果:纳入6项研究,共计3509例胃癌患者。Meta分析结果显示,D-二聚体水平较高的胃癌患者OS(HR=1.57,95%CI:1.21～2.03,P=0.0006)及RFS或DFS(HR=2.26,95%CI:1.70～3.00,P<0.00001)均缩短。根据国家、样本量、D-二聚体临界值及纽卡斯尔-渥太华量表(NOS)评分分组进行亚组分析,结果显示D-二聚体水平较高的胃癌患者OS明显缩短(均P<0.05)。结论:血浆D-二聚体升高与胃癌患者OS、RFS或DFS缩短相关,可以作为胃癌患者的预后指标。
Abstract:
Objective:To analyze the relationship between plasma D-dimer and prognosis of gastric cancer patients.Methods:By searching PubMed,Geen Medical,Cochrane Library,Wanfang Data,CNKI and other domestic and foreign databases for all relevant studies on the relationship between plasma D-dimer and the prognosis of patients with gastric cancer,the retrieval time was from the establishment of the database to December 31,2021.Rev Man software(version 5.4)was used for data analysis.The hazard ratio(HR)with 95% confidence interval(CI)was used to evaluate the correlation between plasma D-dimer and overall survival(OS)and recurrence free survival(RFS)or disease-free survival(DFS)in gastric cancer patients.Results:Six studies were finally included,including 3509 patients with gastric cancer.Meta analysis showed that OS(HR=1.57,95%CI:1.21 to 2.03,P=0.0006)and RFS or DFS(HR=2.26,95%CI:1.70～3.00,P<0.00001)were shortened in patients with gastric cancer with higher D-dimer level.Subgroup analysis according to the country,sample size,D-dimer critical value and NOS score showed that the higher level of D-dimer was related to the shortening of OS in patients with gastric cancer(all P<0.05).Conclusion:The increase of plasma D-dimer is associated with shortening of OS,RFS or DFS in patients with gastric cancer and can be used as a prognostic indicator in patients with gastric cancer.

参考文献/References:

[1] Sung H,Ferlay J,Siegel RL,et al.Global cancer statistics 2020:GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries[J].CA Cancer J Clin,2021,71(3):209-249.
[2] Ferlay J,Shin HR,Bray F,et al.Estimates of worldwide burden of cancer in 2008:GLOBOCAN 2008[J].Int J Cancer,2010,127(12):2893-2917.
[3] Zhang XY,Zhang PY.Gastric cancer:Somatic genetics as a guide to therapy[J].J Med Genet,2017,54(5):305-312.
[4] Hasbahceci M,Malya FU,Kunduz E,et al.Use of serum and peritoneal CEA and CA19-9 in prediction of peritoneal dissemination and survival of gastric adenocarcinoma patients:Are they prognostic factors?[J].Ann R Coll Surg Engl,2018,100(4):257-266.
[5] Sawayama H,Iwatsuki M,Kuroda D,et al.The association of the lymph node ratio and serum carbohydrate antigen 19-9 with early recurrence after curative gastrectomy for gastric cancer[J].Surg Today,2018,48(11):994-1003.
[6] Cheng F,Zeng C,Zeng L,et al.Clinicopathological and prognostic value of preoperative plasma fibrinogen in gastric cancer patients:A meta-analysis[J].Medicine(Baltimore),2019,98(40):e17310.
[7] Shi H,Jiang Y,Cao H,et al.Nomogram based on systemic immune-inflammation index to predict overall survival in gastric cancer patients[J].Dis Markers,2018,2018:1787424.
[8] 申辽辽,贺 丽.血浆纤维蛋白原、血小板计数检测在胃癌诊断与预后评估中的临床意义[J].陕西医学杂志,2021,50(4):489-491.
[9] 郭 栋,魏 鹏,梁 刚,等.原纤维蛋白1在胃癌组织中的表达及与预后的关系[J].陕西医学杂志,2021,50(4):499-502.
[10] Yamada Y,Kawaguchi R,Iwai K,et al.Preoperative plasma D-dimer level is a useful prognostic marker in ovarian cancer[J].J Obstet Gynaecol,2020,40(1):102-106.
[11] Li X,Shu K,Zhou J,et al.Preoperative plasma fibrinogen and D-dimer as prognostic biomarkers for non-muscle-invasive bladder cancer[J].Clin Genitourin Cancer,2020,18(1):11-19.
[12] Watanabe A,Araki K,Harimoto N,et al.D-dimer predicts postoperative recurrence and prognosis in patients with liver metastasis of colorectal cancer[J].Int J Clin Oncol,2018,23(4):689-697.
[13] He X,Huang T,Xue Y,et al.Association of preoperative plasma D-dimmer and fibrinogen and renal cell carcinoma outcome[J].J Cancer,2019,10(17):4096-4105.
[14] Kim EY,Song KY.Prognostic value of D-dimer levels in patients with gastric cancer undergoing gastrectomy[J].Surgical Oncology,2021,37:101570.
[15] Liang Y,He D,Wu L,et al.Elevated preoperative plasma D-dimer dose not adversely affect survival of gastric cancer after gastrectomy with curative intent:A propensity score analysis[J].Chin J Cancer Res,2018,30(2):254-262.
[16] Stang A.Critical evaluation of the Newcastle-Ottawa scale for the assessment of the quality of nonrandomized studies in meta-analyses[J].Eur J Epidemiol,2010,25(9):603-605.
[17] Barili F,Parolari A,Kappetein PA,et al.Statistical primer:Heterogeneity,random- or fixed-effects model analyses?[J].Interact Cardiovasc Thorac Surg,2018,27(3):317-321.
[18] Diao D,Wang Z,Cheng Y,et al.D-dimer:Not just an indicator of venous thrombosis but a predictor of asymptomatic hematogenous metastasis in gastric cancer patients[J].PLoS One,2014,9(7):e101125.
[19] Go S,Lee MJ,Lee WS,et al.D-dimer can serve as a prognostic and predictive biomarker for metastatic gastric cancer treated by chemotherapy[J].Medicine,2015,94(30):e951.
[20] Hara K,Aoyama T,Hayashi T,et al.Postoperative D-dimer elevation affects tumor recurrence and the long-term survival in gastric cancer patients who undergo gastrectomy[J].International Journal of Clinical Oncology,2020,25(4):584-594.
[21] Zhang L,Ren H,Du Y,et al.Combination of preoperative fibrinogen and D-dimer as a prognostic indicator in pancreatic ductal adenocarcinoma patients undergoing R0 resection[J].World Journal of Gastrointestinal Surgery,2021,13(3):279-302.
[22] Rong G,Fan W,Shen J.High pretreatment plasma D-dimer levels predict poor prognosis in gastrointestinal cancers[J].Medicine,2019,98(29):e16520.
[23] Beer JH,Haeberli A,Vogt A,et al.Coagulation markers predict survival in cancer patients[J].Thromb Haemost,2002,88(5):745-749.
[24] Rothwell PM,Wilson M,Elwin CE,et al.Long-term effect of aspirin on colorectal cancer incidence and mortality:Twenty-year follow-up of five randomised trials[J].Lancet,2010,376(9754):1741-1750.

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备注/Memo

备注/Memo:
基金项目:宁夏回族自治区重点研发计划项目(2021BEG03085); 宁夏回族自治区自然科学基金资助项目(2019AAC03200)
更新日期/Last Update: 2022-09-05