[1]白小岗,李 霞,贾爱华,等.2型糖尿病男性患者性激素水平与体重指数、糖脂代谢及胰岛素抵抗相关性分析[J].陕西医学杂志,2022,51(9):1086-1089.[doi:DOI:10.3969/j.issn.1000-7377.2022.09.009]
　BAI Xiaogang,LI Xia,JIA Aihua,et al.Correlation between levels of sex hormones and BMI,glucolipid metabolism and insulin resistance in male patients with type 2 diabetes mellitus[J].,2022,51(9):1086-1089.[doi:DOI:10.3969/j.issn.1000-7377.2022.09.009]
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2型糖尿病男性患者性激素水平与体重指数、糖脂代谢及胰岛素抵抗相关性分析
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《陕西医学杂志》[ISSN:1000-7377/CN:61-1281/TN]

卷:
51
期数:
2022年9期
页码:
1086-1089
栏目:
临床研究
出版日期:
2022-09-05

文章信息/Info

Title:
Correlation between levels of sex hormones and BMI,glucolipid metabolism and insulin resistance in male patients with type 2 diabetes mellitus
作者:
白小岗1; 李 霞1; 贾爱华2; 李 伟1
(1.延安大学附属医院内分泌代谢科,陕西 延安 716000; 2.榆林市第一医院内分泌科,陕西 榆林 719000)
Author(s):
BAI Xiaogang; LI Xia; JIA Aihua; LI Wei
(Department of Endocrinology and Metabolism,Yan'an University Affiliated Hospital,Yan'an 716000,China)
关键词:
2型糖尿病;  男性;  睾酮;  雌二醇;  糖脂代谢;  胰岛素抵抗
Keywords:
Type 2 diabetes mellitus;  Male;  Testosterone;  Estradiol;  Glucolipid metabolism;  Insulin resistance
分类号:
R 587.1
DOI:
DOI:10.3969/j.issn.1000-7377.2022.09.009
文献标志码:
A
摘要:
目的:分析2型糖尿病(T2DM)男性患者性激素水平与体重指数(BMI)、糖脂代谢及胰岛素抵抗的相关性。方法:选取T2DM男性患者80例,根据BMI分别纳入T2DM肥胖组(55例,BMI≥28 kg/m2)和T2DM非肥胖组(25例,BMI<28 kg/m2),另选择同时期男性体检健康者纳入对照组(50例)。分别比较三组一般资料、性激素指标[睾酮(T)、雌二醇(E2)、雌二醇/睾酮比值(E2/T)]、脂代谢指标[低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)、甘油三酯(TG)、总胆固醇(TC)]、糖代谢指标[空腹血糖(FPG)、空腹胰岛素(FINS)、糖化血红蛋白(HbA1c)、胰岛素抵抗指数(HOMA-IR)]。采用Pearson法分析T2DM男性患者性激素水平与BMI、糖脂代谢指标及胰岛素抵抗的相关性。结果:T2DM肥胖组、T2DM非肥胖组、对照组BMI呈递减趋势(均P<0.05)。三组年龄比较差异无统计学意义(P>0.05)。T2DM肥胖组及T2DM非肥胖组T2DM病程比较差异无统计学意义(P>0.05)。T2DM肥胖组、T2DM非肥胖组、对照组血清T水平呈递增趋势,E2和E2/T水平呈递减趋势(均P<0.05)。T2DM肥胖组、T2DM非肥胖组、对照组血清HDL-C水平呈递增趋势,LDL-C水平呈递减趋势(均P<0.05)。T2DM肥胖组TC和TG水平高于其他两组(均P<0.05)。T2DM肥胖组、T2DM非肥胖组、对照组的FPG、FINS、HbA1c、HOMA-IR水平呈递减趋势(均P<0.05)。T2DM男性患者血清T与BMI、LDL-C、FPG、FINS、HbA1c、HOMA-IR呈负相关,与HDL-C呈正相关(均P<0.05); E2和E2/T与BMI、LDL-C、FPG、FINS、HbA1c、HOMA-IR呈正相关,与HDL-C呈负相关(均P<0.05)。结论:T2DM男性患者血清T、E2及E2/T水平与BMI、糖脂代谢紊乱及胰岛素抵抗密切相关。
Abstract:
Objective:To analyze the correlation between levels of sex hormones and body mass index(BMI),glucolipid metabolism and insulin resistance in male patients with type 2 diabetes mellitus(T2DM).Methods:A total of 80 male patients with T2DM were classified into T2DM obesity group(55 cases,BMI higher than or equal to 28 kg/m2)and T2DM non-obesity group(25 cases,BMI lower than 28 kg/m2)according to BMI,and the healthy male subjects in the same period were included in control group(50 cases).The general data,sex hormones indicators(T,E2,E2/T),lipid metabolism indicators(LDL-C,HDL-C,TG,TC)and glucose metabolism indicators(FPG,FINS,HbAlc,HOMA-IR)were compared among the three groups.Pearson method was used to analyze the correlation between sex hormone levels and BMI,glucolipid metabolism indexes and insulin resistance in male patients with T2DM.Results:BMI of T2DM obesity group,T2DM non- obesity group and control group showed a decreasing trend(all P<0.05).There was no significant difference in age among the three groups(P>0.05).There was no significant difference in the course of T2DM between T2DM obesity group and T2DM non-obesity group(P>0.05).The serum T levels of T2DM obesity group,T2DM non-obesity group and control group showed an increasing trend,while E2 and E2/T levels showed a decreasing trend(all P<0.05).The serum HDL-C level of T2DM obesity group,T2DM non-obesity group and control group showed an increasing trend,while the LDL-C level showed a decreasing trend(all P<0.05).The levels of TC and TG in T2DM obesity group were higher than those in other two groups(all P<0.05).The levels of FPG,FINS,HbA1c and HOMA-IR in T2DM obesity group,T2DM non-obesity group and control group showed a decreasing trend(all P<0.05).Serum T in male patients with T2DM was negatively correlated with BMI,LDL-C,FPG,FINS,HbA1c,HOMA-IR,and positively correlated with HDL-C(all P<0.05).E2 and E2/T were positively correlated with BMI,LDL-C,FPG,FINS,HbA1c,HOMA-IR,and negatively correlated with HDL-C(all P<0.05).Conclusion:Serum T,E2 and E2/T levels in male patients with T2DM are closely related to BMI,glucolipid metabolism disorders and insulin resistance.

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备注/Memo

备注/Memo:
基金项目:陕西省卫生健康科研基金资助项目(2021D015)
更新日期/Last Update: 2022-09-05