[1]封佑琪,陈 珊,汪鸿浩,等.高迁移率族蛋白B1在多发性硬化中的作用机制研究进展[J].陕西医学杂志,2022,51(7):902-封3.[doi:DOI:10.3969/j.issn.1000-7377.2022.07.033]
　FENG Youqi,CHEN Shan,WANG Honghao,et al.Research progress on mechanism of high mobility group protein B1 in multiple sclerosis[J].,2022,51(7):902-封3.[doi:DOI:10.3969/j.issn.1000-7377.2022.07.033]
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高迁移率族蛋白B1在多发性硬化中的作用机制研究进展
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《陕西医学杂志》[ISSN:1000-7377/CN:61-1281/TN]

卷:
51
期数:
2022年7期
页码:
902-封3
栏目:
综 述
出版日期:
2022-07-05

文章信息/Info

Title:
Research progress on mechanism of high mobility group protein B1 in multiple sclerosis
作者:
封佑琪1; 2; 陈 珊1; 2; 汪鸿浩3; 顿玲露1; 周哲屹1
(1.广西中医药大学,广西 南宁 530200; 2.柳州市中医医院神经内科,广西 柳州 545002; 3.南方医科大学附属南方医院神经内科,广东 广州 510515)
Author(s):
FENG Youqi; CHEN Shan; WANG Honghao; DUN Linglu; ZHOU Zheyi
(Guangxi University of Chinese Medicine,Nanning 530200,China)
关键词:
高迁移率族蛋白B1;  多发性硬化;  发病机制;  神经系统疾病;  新靶点
Keywords:
High mobility group protein B1;  Multiple sclerosis;  Pathogenesis;  Nervous system disease;  New target
分类号:
R 593.2
DOI:
DOI:10.3969/j.issn.1000-7377.2022.07.033
文献标志码:
A
摘要:
多发性硬化(MS)是一种由免疫系统故障引起的神经系统疾病,导致针对脑白质组织抗原的自身免疫反应。高迁移率族蛋白B1(HMGB1)近年来在炎症反应及自身免疫性疾病中的作用得到广泛关注,但是HMGB1对MS的作用机制的报道相对较少。有研究表明,HMGB1可能成为治疗MS的新靶点。现就HMGB1的结构、来源及信号传导通路,HMGB1在MS中的作用及相关机制的研究进展做一综述,以期为MS的诊疗提供新的靶点,为进一步临床和实验研究提供基础。
Abstract:
Multiple sclerosis(MS)is a neurological disease caused by a failure of the immune system,which leads to an autoimmune response to white matter tissue antigens.In recent years,the role of high mobility group protein B1(HMGB1)in inflammatory response and autoimmune diseases has been widely concerned,but there are relatively few reports on the mechanism of MS by HMGB1.Some studies have shown that HMGB1 may become a new target for the treatment of MS.This article reviews the structure,source and signal transduction pathway of HMGB1,the role of HMGB1 in MS and related mechanisms,in order to provide a new target for the diagnosis and treatment of MS and provide a basis for further clinical and experimental research.

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备注/Memo

备注/Memo:
基金项目:国家自然科学基金资助项目(82060905); 广西自然科学基金资助项目(2019GXNSFAA245079); 广西省柳州市科技计划项目(2020PAAA0610,2021CBC0133,2021CBB0112)
更新日期/Last Update: 2022-07-05