[1]邹 鹏,罗 鹏,杨二万,等.线粒体SIRT3功能及其在中枢神经系统疾病中的作用研究进展[J].陕西医学杂志,2022,51(7):898-901,封3.[doi:DOI:10.3969/j.issn.1000-7377.2022.07.032]
　ZOU Peng,LUO Peng,YANG Erwan,et al.Function of mitochondrial SIRT3 and its recent research progress in central nervous system diseases[J].,2022,51(7):898-901,封3.[doi:DOI:10.3969/j.issn.1000-7377.2022.07.032]
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线粒体SIRT3功能及其在中枢神经系统疾病中的作用研究进展
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《陕西医学杂志》[ISSN:1000-7377/CN:61-1281/TN]

卷:
51
期数:
2022年7期
页码:
898-901,封3
栏目:
综 述
出版日期:
2022-07-05

文章信息/Info

Title:
Function of mitochondrial SIRT3 and its recent research progress in central nervous system diseases
作者:
邹 鹏1; 罗 鹏1; 杨二万1; 张昊阜1; 刘 剑1; 蒋晓帆1; Takashi H2(日本)
(1.空军军医大学西京医院神经外科,陕西 西安 710032; 2.日本札幌中央区札幌医科大学医学院药学系,日本 札幌 063-0000)
Author(s):
ZOU Peng; LUO Peng; YANG Erwan; ZHANG Haofuzi; LIU Jian; JIANG Xiaofan; Takashi H
(Department of Neurosurgery,Xijing Hospital,Air Force Medical University,Xi'an 710032,China)
关键词:
线粒体;  沉默信息调控子;  去乙酰化酶;  氧化应激;  中枢神经系统;  生物衰老
Keywords:
Mitochondria;  Silent information regulator;  Deacetylase;  Oxidative stress;  Central nervous system;  Biological aging
分类号:
R 742
DOI:
DOI:10.3969/j.issn.1000-7377.2022.07.032
文献标志码:
A
摘要:
线粒体中的沉默信息调节因子同源蛋白3(SIRT3)具有重要的去乙酰化酶,可影响线粒体的乙酰化水平,进一步调控许多信号通路,在细胞内形成密切的调控关系网络。迄今为止,SIRT3已被证实参与了几乎所有与线粒体代谢和稳态相关的病理生理过程,并且保护线粒体免受各种损伤。只有了解SIRT3如何调节各类病理生理过程,才能熟知如何扩大SIRT3的保护作用、优化病理代谢、氧化应激、生物衰老等过程。因此,重点综述线粒体SIRT3的功能及其在中枢神经系统疾病中的作用研究进展,以期在未来的药物发现中明确其治疗靶点,为临床提供科学指导意义。
Abstract:
Mitochondrial silencing information regulator homologous protein 3(SIRT3)has an important deacetylase that affects mitochondrial acetylation levels and further regulate many signaling pathways,forming a close regulatory network in cells.To date,SIRT3 has been shown to be involved in almost all pathophysiological processes related to mitochondrial metabolism and homeostasis,and to protect mitochondria from various injuries.Only by understanding how SIRT3 regulates various pathophysiological processes can we understand how to expand the protective effect of SIRT3 and optimize pathological metabolism,oxidative stress,biological aging and other processes.Therefore,we focused on reviewing the function of mitochondrial SIRT3 and the latest research progress in central nervous system diseases,in order to identify its therapeutic targets in future drug discovery and provide scientific guidance for clinical practice.

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备注/Memo

备注/Memo:
基金项目:国家自然科学基金资助面上项目(82171458)
更新日期/Last Update: 2022-07-05