[1]林晓溪,张俊毅.斑菲素蛋白2在食管鳞状细胞癌组织中的表达及临床意义[J].陕西医学杂志,2022,51(6):741-744.[doi:DOI:10.3969/j.issn.1000-7377.2022.06.024]
　LIN Xiaoxi,ZHANG Junyi.Expression of plakophilin 2 in esophageal squamous cell carcinoma and its clinical significance[J].,2022,51(6):741-744.[doi:DOI:10.3969/j.issn.1000-7377.2022.06.024]
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斑菲素蛋白2在食管鳞状细胞癌组织中的表达及临床意义
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《陕西医学杂志》[ISSN:1000-7377/CN:61-1281/TN]

卷:
51
期数:
2022年6期
页码:
741-744
栏目:
临床病理
出版日期:
2022-06-05

文章信息/Info

Title:
Expression of plakophilin 2 in esophageal squamous cell carcinoma and its clinical significance
作者:
林晓溪1; 2; 张俊毅3; 4
(1.锦州医科大学赤峰学院培养基地,内蒙古 赤峰 024099; 2.赤峰市医院肿瘤内科,内蒙古 赤峰 024099; 3.赤峰学院附属医院病理科,内蒙古 赤峰 024099; 4.赤峰学院临床病理研究所,内蒙古 赤峰 024099)
Author(s):
LIN Xiaoxi; ZHANG Junyi
(Training Base of Chifeng College of Jinzhou Medical University,Chifeng 024099,China)
关键词:
食管鳞状细胞癌;  斑菲素蛋白2;  预后;  生存时间;  淋巴结转移;  预测价值
Keywords:
Esophageal squamous cell carcinoma;  Plakophilin 2;  Prognosis;  Survival time;  Lymph node metastasis;  Predictive value
分类号:
R 735.1
DOI:
DOI:10.3969/j.issn.1000-7377.2022.06.024
文献标志码:
A
摘要:
目的:观察斑菲素蛋白2(PKP2)在食管鳞状细胞癌(ESCC)组织中的表达情况,分析其临床意义。方法:选择115例ESCC组织标本、20例癌旁正常食管组织标本为研究对象。检测所有标本PKP2表达情况。比较ESCC组织标本与正常癌旁组织标本PKP2阳性表达检出率。分析PKP2表达与临床病理参数间的关系。比较不同PKP2表达患者生存情况。比较ESCC组织与正常癌旁组织PKP2 mRNA相对表达量。采用受试者工作特征(ROC)曲线分析PKP2的预测价值。结果:115例ESCC组织中,检出PKP2高表达54例,检出率为46.96%,较20例癌旁正常组织显著增高(P<0.05)。与阴性表达组比,阳性表达组患者TNM高分期占比高,淋巴结转移率高(均P<0.05)。生存分析发现,PKP2阳性表达患者生存时间较阴性表达组短(P<0.05)。ROC曲线分析发现,PKP2阳性表达用于预测淋巴结转移、TNM分期的曲线下面积(AUC)为0.785和0.763,有一定预测价值。结论:PKP2在ESCC组织中普遍呈高表达,对预测患者生存情况、TNM分期及淋巴结转移有一定应用价值。
Abstract:
Objective:To observe the expression of plakophilin 2(PKP2)in esophageal squamous cell carcinoma(ESCC)and analyze its clinical significance.Methods: A total of 115 specimens of ESCC tissues and 20 specimens of normal adjacent tissue specimens were selected.The expression of PKP2 in all specimens was detected.The positive expression rate of PKP2 was compared between ESCC tissues and normal adjacent tissues.The relationship between PKP2 expression and clinicopathological parameters was analyzed.The survival of patients with different PKP2 expression was compared.The relative expression of PKP2 mRNA in ESCC tissues was compared with that in normal adjacent tissues.Receiver operating characteristic(ROC)curve was used to analyze the predictive value of PKP2.Results:Among 115 cases of ESCC tissues,54 cases of high expression of PKP2 were detected,the detection rate was 46.96%,which was higher than that of 20 cases of normal tissues adjacent to cancer(P<0.05).Compared with the negative expression group,the proportion of TNM high staging and the rate of lymph node metastasis in the positive expression group was higher(P<0.05).Survival analysis found that the survival time of patients with positive expression of PKP2 was shorter than patients with negative expression of PKP2(P<0.05).ROC curve analysis found that the AUC of positive expression of PKP2 in predicting lymph node metastasis and TNM staging was 0.785 and 0.763,both >0.70,with certain predictive value.Conclusion:PKP2 is generally highly expressed in ESCC tissues,and it has certain application value in predicting the survival condition,TNM stage and lymph node metastasis of patients.

参考文献/References:

[1] 梁宗英,孙光蕊,赵宝山,等.三磷酸腺苷结合盒转运子E1与P300/CBP相关因子在食管鳞癌组织中的表达及临床意义[J].陕西医学杂志,2020,49(10):1356-1358.
[2] 汤 虹,吴育锋,贾永旭,等.细胞黏附样分子L1对食管鳞状细胞癌转移的抑制作用[J].中华消化杂志,2018,38(3):158-164.
[3] 林富强,谢德耀,程德志,等.临床分期对食管癌根治手术患者生存状况的预测效果[J].中国现代医学杂志,2015,25(10):74-78.
[4] Chen YH,Lu I,Wang YM,et al.The prognostic significance of celiac lymph node metastasis in patients with locally advanced esophageal squamous cell carcinoma receiving curative concurrent chemoradiotherapy[J].Oncotarget,2017,8(56):96190-96202.
[5] Gurha P,Chen X,Lombardi R,et al.Knock down of plakophilin 2 downregulates miR-184 through CpG hypermethylation and suppression of the E2F1 pathway and leads to enhanced adipogenesis in vitro[J].Circ Res,2016,119(6):731-750.
[6] 张俊毅,孙志娟,李 蕾.Plakophilin2蛋白在非小细胞肺癌中的表达及其临床意义[J].中国癌症杂志,2012,22(2):125-129.
[7] Thomas W.Staging of esophageal cancer:TNM and beyond[J].Esophagus,2010,7(4):189-195.
[8] 陈龙奇.食管癌国际TNM分期第7版解读与评价[J].中华肿瘤杂志,2010,32(3):237-240.
[9] 南新记,栗广辉,王志峰.利膈散联合顺铂方案治疗食管癌效果及对患者炎性因子、生活质量和不良反应的影响[J].陕西中医,2019,40(1):58-60.
[10] 王家林,田 伟,陈耀华,等.食管鳞状细胞癌患者术前血清纤维蛋白原水平与病理特征及预后关系探讨[J].陕西医学杂志,2020,49(5):630-634.
[11] 黄显聪,赵 强,凌志强,等.EGFR mRNA上调在食管鳞状细胞癌患者预后预测中的意义[J].肿瘤学杂志,2016,22(3):199-204.
[12] Qin HD,Liao XY,Chen YB,et al.Genomic characterization of esophageal squamous cell carcinoma reveals critical genes underlying tumorigenesis and poor prognosis[J].Am J Hum Genet,2016,98(4):709-727.
[13] Wu X,Lim ZF,Li Z,et al.NORAD expression is associated with adverse prognosis in esophageal squamous cell carcinoma[J].Oncol Res Treat,2017,40(6):370-374.
[14] Jiang Y,Lo AWI,Wong A,et al.Prognostic significance of tumor-infiltrating immune cells and PD-L1 expression in esophageal squamous cell carcinoma[J].Oncotarget,2017,8(18):30175-30189.
[15] 王跃兵,马 琳,唐 雪,等.云南不明原因猝死病区人群PKP2基因突变研究[J].中华地方病学杂志,2019,38(2):111-116.
[16] Masic S,Brcic L,Kruslin B,et al.Expression of plakophilin 3 in diffuse malignant pleural mesothelioma[J].Histol Histopathol,2018,33(9):995-1004.
[17] Basu S,Thorat R,Dalal SN.MMP7 is required to mediate cell invasion and tumor formation upon plakophilin3 loss[J].PLoS One,2015,10(4):257-262.
[18] Campuzano O,Fernandez-Falgueras A,Iglesias A,et al.Brugada syndrome and PKP2:Evidences and uncertainties[J].Int J Cardiol,2016,225(214):403-405.
[19] Xu Y,Cai Q.Abstract 5054:Role and signaling of desmosomal DSP and PKP1 in ovarian cancer[J].Can Res,2016,76(14):5054.
[20] Fujita J,Nakajima M,Muroi H,et al.The prognostic significance of plakophilin-1 expression in esophageal cancer[J].Anticancer Res,2021,41(7):3401-3407.

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备注/Memo

备注/Memo:
基金项目:国家自然科学基金资助项目(81860507)
更新日期/Last Update: 2022-06-06