[1]徐 珊,程 珂,刘鹏宇.子宫内膜癌组织血管紧张素(1-7)、miR-106b表达与患者临床病理分期相关性研究[J].陕西医学杂志,2022,51(5):621-624.[doi:DOI:10.3969/j.issn.1000-7377.2022.05.025]
　XU Shan,Cheng Ke,LIU Pengyu.Correlation between the expression of angiotensin(1-7),miR-106b in endometrial cancer tissue and clinicopathological stage of patients[J].,2022,51(5):621-624.[doi:DOI:10.3969/j.issn.1000-7377.2022.05.025]
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子宫内膜癌组织血管紧张素(1-7)、miR-106b表达与患者临床病理分期相关性研究
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《陕西医学杂志》[ISSN:1000-7377/CN:61-1281/TN]

卷:
51
期数:
2022年5期
页码:
621-624
栏目:
临床病理
出版日期:
2022-05-05

文章信息/Info

Title:
Correlation between the expression of angiotensin(1-7),miR-106b in endometrial cancer tissue and clinicopathological stage of patients
作者:
徐 珊1; 程 珂1; 刘鹏宇2
(1.新乡医学院第三附属医院妇科,河南 新乡 453003; 2.新乡医学院医院管理处,河南 新乡 453003)
Author(s):
XU Shan; Cheng Ke; LIU Pengyu
(Department of Gynecology,the Third Affiliated Hospital of Xinxiang Medical College,Xinxiang 453003,China)
关键词:
子宫内膜癌;  血管紧张素(1-7);  病理分期;  miR-106b表达;  相关性;  有序多分类逻辑回归
Keywords:
Endometrial carcinoma;  Angiotensin(1-7);  Pathological stage;  miR-106b expression;  Correlation;  Ordered multi-class logistic regression
分类号:
R 737.33
DOI:
DOI:10.3969/j.issn.1000-7377.2022.05.025
文献标志码:
A
摘要:
目的:探究子宫内膜癌患者子宫内膜组织中血管紧张素(1-7)、微小RNA-106b(miR-106b)表达情况及其与患者病理分期间的关系。方法:107例子宫内膜癌患者作为患病组,据其TNM病理分期分为Ⅰ-Ⅱ期组(n=69例),Ⅲ-Ⅳ期组(n=38例),另择20例同期健康子宫内膜组织为健康组,对比两组及不同病理分组患者子宫内膜组织血管紧张素(1-7)、miR-106b表达情况,Pearson检验分析血管紧张素(1-7)、miR-106b和病理分期间的相关性,并以有序多分类逻辑回归分析子宫内膜癌病理分期和血管紧张素(1-7)、miR-106b间的关系。结果:患病组患者血管紧张素(1-7)和miR-106b水平均高于健康组(均P<0.05),Ⅰ-Ⅱ期组血管紧张素(1-7)低于Ⅲ-Ⅳ期组,Ⅰ-Ⅱ期组miR-106b高于Ⅲ-Ⅳ期组(均P<0.05); Pearson检验表明子宫内膜癌患者血管紧张素(1-7)与病理分期呈正相关,miR-106b表达与病理分期呈负相关(均P<0.05); Logistic回归分析表明,子宫内膜癌患者子宫内膜血管紧张素(1-7)、miR-106b表达和其病理分期间关系密切(均P<0.05)。结论:子宫内膜癌患者存在子宫内膜组织血管紧张素(1-7)和miR-106b的异常升高,且其表达和TNM病理分期关系密切,血管紧张素(1-7)与病理分期呈正相关,miR-106b与其呈负相关,临床可将其作为不同病理分期患者的治疗靶点。
Abstract:
Objective:To investigate the expression of angiotensin(1-7),miR-106b in endometrial tissue of patients with endometrial cancer and their relationship with the pathological stages of patients.Methods:A total of 107 patients with endometrial cancer were selected as the disease group.According to their TNM pathological stage,they were divided into stage Ⅰ-Ⅱ group(69 cases),stage Ⅲ-Ⅳ group(38 cases).Another 20 objects with healthy endometrial tissues in the same period were selected as the healthy group.The expressions of angiotensin(1-7)and miR-106b in endometrial tissues of the two groups and different pathological groups were compared.The correlation between angiotensin(1-7),miR-106b and pathological stage was analyzed by Pearson test.The relationship between pathological stage of endometrial carcinoma and angiotensin(1-7),miR-106b was analyzed by ordered multi-class Logistic regression.Results:The levels of angiotensin(1-7)and miR-106b in the disease group were higher than those in the healthy group(all P<0.05).angiotensin(1-7)level in stage Ⅰ-Ⅱ group was lower than that in stage Ⅲ-Ⅳ group,and miR-106b level in stage Ⅰ-Ⅱ group was higher than that in stage Ⅲ-Ⅳ group(allP<0.05).Pearson test showed that angiotensin(1-7)was positively correlated with pathological stage,and the expression of miR-106b was negatively correlated with pathological stage(all P<0.05).Logistic regression analysis showed that the expressions of angiotensin(1-7)and miR-106b in endometrium of patients with endometrial cancer were closely related to their pathological stages(all P<0.05).Conclusion:Angiotensin(1-7)and miR-106b are abnormally increased in endometrial tissue in patients with endometrial carcinoma,and its expression is closely related to TNM pathological stage.Angiotensin(1-7)is positively correlated with pathological stage,while miR-106b is negatively correlated with it.It can be used as a therapeutic target for patients with different pathological stages.

参考文献/References:

[1] 任伟利,温德惠,罗 兵,等.经阴道彩超联合血清HE4、miR-21诊断早期子宫内膜癌价值[J].中国计划生育学杂志,2021,29(1):189-192,封3.
[2] 王 博,薛 锋,刘娟妮,等.FOXJ1基因与肿瘤相关性研究进展[J].陕西医学杂志,2017,46(10):1487-1489.
[3] 刘家利,谢小军.子宫内膜癌组织HIF-1α、血清CA125水平在患者病情与疾病预后评估中的价值[J].陕西医学杂志,2019,48(6):800-802.
[4] 徐洪阁,丁红岩,张 婷.过表达miR-132-3p对子宫内膜癌细胞增殖、凋亡、侵袭及迁移的作用[J].诊断病理学杂志,2021,28(7):546-551.
[5] 张碧艳,杨 苗,金晓峰.miR-34a蛋白在子宫内膜癌细胞中的表达及其对癌细胞增殖凋亡机制的影响[J].浙江临床医学,2021,23(9):1252-1254,1258.
[6] 马宇光,昝 瑛,王 梦,等.LncRNA NNT-AS1和miR-424在子宫内膜癌组织中的表达及其临床意义[J].国际检验医学杂志,2021,42(11):1376-1381.
[7] 中国抗癌协会妇科肿瘤专业委员会.子宫内膜癌诊断与治疗指南(第四版)[J].中国实用妇科与产科杂志,2018,34(8):880-886.
[8] 陆小宇,罗 慧,何 鸳,等.凤香洗液中“丁香-苦参”配伍干预子宫内膜癌的活性成分及作用机制预测分析[J].陕西中医,2021,42(12):1808-1813.
[9] 冯苗苗,曹秋雨.miR-335在子宫内膜癌患者血清中的表达及检测临床意义[J].陕西医学杂志,2019,48(2):252-255.
[10] 高 歌.黄芪注射液治疗子宫内膜肿瘤临床疗效及对患者肿瘤标志物血清CA125、HE4影响的研究[J].陕西中医,2018,39(6):762-765.
[11] 吴天玉,刘湘鄂,许 海.LncRNA H19、miR-29b、miR-124在子宫内膜癌组织中的表达及临床意义[J].检验医学与临床,2019,16(11):1483-1487.
[12] 陈丽华,朱婕曼,刘玉凤,等.子宫内膜癌组织中血管紧张素(1-7)及线粒体组装受体水平表达与临床病理特征的相关性[J].现代检验医学杂志,2021,36(2):24-27.
[13] 张 竹,许 乐,贾文卓.基于ROC曲线分析血清miR-375、miR-106b和AFP在肝癌早期诊断中的价值[J].标记免疫分析与临床,2020,27(5):779-781,838.
[14] 李 虹,秦 艳,郝小白,等.人乳头瘤病毒阳性宫颈癌患者血清miR-106b-5p和miR-497-5p表达变化及意义[J].中华实用诊断与治疗杂志,2021,35(7):683-687.
[15] 李黎明.MiR-106b对子宫肌瘤细胞增殖、侵袭和凋亡的影响及与SULT2A1的靶向关系[J].中国药师,2021,24(4):647-652.
[16] 董爱华,韩 克.子宫内膜癌组织中miR-106b、DAB2表达与临床病理及预后的相关性[J].中国计划生育学杂志,2018,26(9):787-792.
[17] 王婷婷,王 芳.LncRNA CASC9和MiR-193a-5p在子宫内膜癌组织中的表达及临床意义[J].标记免疫分析与临床,2021,28(1):65-70,75.
[18] 郭春玲,逯朝阳,杨 滨,等.血管紧张素(1-7)通过p53/Drp1轴对血管紧张素Ⅱ诱导的血管内皮细胞衰老的影响[J].中国动脉硬化杂志,2020,28(11):960-965.
[19] 陈丽华,朱婕曼,刘玉凤,等.Ang-(1-7)、ACE2、Mas与子宫内膜癌患者临床和病理特征关系研究[J].临床误诊误治,2020,33(11):85-90.
[20] 董小锋,钟敬涛,刘天奇,等.血管生成素-2通过整合素α5β1调控血管包绕的肿瘤细胞巢阳性肝细胞癌的癌巢转移[J].中华医学杂志,2021,101(9):654-660.

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更新日期/Last Update: 2022-05-05