[1]张 蕾,高 漫,高 瑜,等.超声联合血清CA125检测对结核性输卵管炎诊断价值研究[J].陕西医学杂志,2022,51(5):604-607.[doi:DOI:10.3969/j.issn.1000-7377.2022.05.021]
　ZHANG Lei,GAO Man,GAO Yu,et al.Diagnostic value of ultrasound combined with serum CA125 in tuberculous salpingitis[J].,2022,51(5):604-607.[doi:DOI:10.3969/j.issn.1000-7377.2022.05.021]
点击复制

超声联合血清CA125检测对结核性输卵管炎诊断价值研究
分享到：

《陕西医学杂志》[ISSN:1000-7377/CN:61-1281/TN]

卷:
51
期数:
2022年5期
页码:
604-607
栏目:
临床检验
出版日期:
2022-05-05

文章信息/Info

Title:
Diagnostic value of ultrasound combined with serum CA125 in tuberculous salpingitis
作者:
张 蕾; 高 漫; 高 瑜; 解建毅; 巩 佩; 吴 键; 惠立本
(陕西省结核病防治院,陕西 西安 710100)
Author(s):
ZHANG Lei; GAO Man; GAO Yu; XIE Jianyi; GONG Pei; WU Jian; HUI Liben
(Shaanxi Provincial Tuberculosis Prevention and Treatment Hospital,Xi'an 710100,China)
关键词:
经阴道超声;  血清CA125;  联合检测;  结核性输卵管炎;  诊断价值;  早期筛查
Keywords:
Transvaginal ultrasound;  Serum CA125;  Combined detection;  Tuberculous salpingitis;  Diagnostic value;  Early screening
分类号:
R 527.4
DOI:
DOI:10.3969/j.issn.1000-7377.2022.05.021
文献标志码:
A
摘要:
目的:探究超声联合血清CA125检测对结核性输卵管炎的诊断临床价值。方法:选取接受治疗的80例疑似结核性输卵管炎患者为研究对象,分别对其开展经阴道超声检查及血清学检测,以病理学检查结果为金标准,分别评估经阴道超声、血清CA125以及阴道超声联合CA125检测对结核性输卵管炎的诊断价值,并分别绘制ROC曲线计算曲线下面积(AUC)。结果:①经阴道超声对结核性输卵管炎诊断一致性为61.25%,灵敏度为58.82%,特异度为75.00%,阳性预测值为93.02%,阴性预测值为24.32%; ②血清CA125对结核性输卵管炎诊断一致性为60.00%,灵敏度为63.24%,特异度为41.67%,阳性预测值为86.00%,阴性预测值为16.67%; ③经阴道超声联合血清CA125对结核性输卵管炎诊断一致性为96.25%,灵敏度为97.06%,特异度为91.67%,阳性预测值为98.51%,阴性预测值为84.62%; ④超声对结核性输卵管炎诊断AUC为0.6500(P=0.0011),血清CA125对结核性输卵管炎诊断AUC为0.6125(P=0.0140),联合检测对结核性输卵管炎诊断AUC为0.6563(P=0.0006)。结论:经阴道超声与血清CA125对结核性输卵管炎都具有较好的诊断效能,但联合检测能够明显提高诊断的一致性、灵敏度和特异度,建议临床上可将上述两种方式联合起来用于结核性输卵管炎的初筛中。
Abstract:
Objective:To explore the clinical value of ultrasound combined with serum CA125 in the diagnosis of tuberculous salpingitis.Methods: Eighty patients with suspected tuberculous salpingitis were selected as the research object,and transvaginal ultrasound and serological examination were carried out respectively.Taking pathological examination results as the gold standard,the diagnostic value of transvaginal ultrasound,serum CA125 and transvaginal ultrasound combined with CA125 in tuberculous salpingitis was evaluated respectively,and ROC curves were drawn to calculate the area under the curve(AUC).Results:The consistency of transvaginal ultrasound in the diagnosis of tuberculous salpingitis was 61.25%,the sensitivity was 58.82%,the specificity was 75.00%,the positive predictive value was 93.02%,and the negative predictive value was 24.32%.The consistency of serum CA125 in the diagnosis of tuberculous salpingitis was 60.00%,the sensitivity was 63.24%,the specificity was 41.67%,the positive predictive value was 86.00%,the negative predictive value was 16.67%.The consistency of transvaginal ultrasound combined with serum CA125 in the diagnosis of tuberculous salpingitis was 96.25%,the sensitivity was 97.06%,the specificity was 91.67%,the positive predictive value was 98.51%,the negative predictive value was 84.62%.The AUC for ultrasound diagnosis of tuberculous salpingitis was 0.6500(P=0.0011),for serum CA125 was 0.6125(P=0.0140),and for combined detection was 0.6563(P=0.0006).Conclusion:Both transvaginal ultrasound and serum CA125 have good diagnostic efficacy for tuberculous salpingitis,but combined detection can obviously improve the consistency,sensitivity and specificity of diagnosis.It is suggested that the above two methods can be combined for the primary screening of tuberculous salpingitis clinically.

参考文献/References:

[1] 吴 嫣,顾 青,刘继红,等.中药保留灌肠联合八段锦治疗输卵管阻塞性不孕症临床研究[J].陕西中医,2019,40(7):835-838.
[2] 王 晔,刘艳巧,卢清秀,等.化瘀通管汤结肠灌肠对输卵管阻塞不孕症的影响[J].陕西中医,2017,38(3):368-369.
[3] 程 萍,杨 飚.输卵管处理方案选择对行腹腔镜全子宫切除术患者手术相关临床指标、激素及MPS发生率的影响[J].陕西医学杂志,2018,47(5):571-573,576.
[4] 胡喜姣,李硕熙,刘进哲,等.针药联合治疗气滞血瘀型输卵管炎性不孕症临床研究[J].中医药信息,2018,35(1):101-103.
[5] 周巧云,黄晓武.宫腔镜代输卵管镜应用于评价输卵管积水黏膜状况[J].国际生殖健康/计划生育杂志,2017,36(3):195-198.
[6] 苏 红,吕开红,杨 勇.超声造影诊断输卵管源性不育症的临床应用价值[J].临床超声医学杂志,2017,19(10):679-681.
[7] 张 宇,薛勤梅.TGF-β1和CTGF与输卵管炎性阻塞性不孕输卵管纤维化相关性的研究进展[J].中国医药导报,2021,18(6):50-53.
[8] 刘 丽,程英龙,刘进哲,等.膈下逐瘀汤加减方对气滞血瘀型慢性输卵管炎大鼠中医证候、血液流变学及TNF-α、IFN-β表达的影响[J].现代中西医结合杂志,2020,29(11):1141-1144,1148.
[9] 梁群英,钟月英,毛云飞,等.阶段性健康教育联合心理干预对输卵管炎性不孕患者的影响[J].中国健康教育,2020,36(11):1045-1048.
[10] 胡喜姣,李硕熙,郑 跃,等.基于血流变及炎性因子探讨膈下逐瘀汤加减方对输卵管炎性不孕大鼠作用机制研究[J].世界中西医结合杂志,2018,13(4):4.
[11] 杜 涛,黄国权,汪健文.多层螺旋CT对输卵管炎的诊断价值[J].生物医学工程与临床,2019,23(6):674-677.
[12] 胡喜姣,林春盛,李硕熙,等.金黄色葡萄球菌致急性与慢性输卵管炎性不孕症大鼠模型的建立[J].中国比较医学杂志,2018,28(8):56-61.
[13] 郭春燕,张 琳.抗炎通管汤对慢性输卵管炎大鼠IL-1β表达的影响[J].甘肃科学学报,2018,30(3):52-55.
[14] 马瑞丽,王艳丽,毕寒晶,等.宫腹腔镜联合诊治女性复杂原因继发不孕的研究[J].河北医药,2018,30(3):52-55.
[15] 钟慧虹,马 娴,沈关桢.中药多途径方案辅助宫腔镜腹腔镜手术治疗输卵管阻塞性不孕临床分析[J].中国药物与临床,2018,18(4):573-575.
[16] 陈 航,黄晓武.宫腔镜代输卵管镜对输卵管远端黏膜评价的研究[J].国际生殖健康/计划生育杂志,2018,37(5):372-376,400.
[17] 杨秀霞.育龄期女性人工流产术后继发性不孕的危险因素分析[J].中国妇幼保健,2020,35(15):2856-2858.
[18] 贾 静,郭运年.宫腔内注射治疗结核性输卵管炎39例的疗效分析[J].山西妇幼卫生,1995,6(3):46-47.
[19] 冯 征,骆周展,唐梦瑶.经腹部超声和经阴道超声在妇产科急腹症诊断中的价值[J].解放军预防医学杂志,2019,37(4):112-113.
[20] 李天刚,王 刚,祁平安,等.实时三维输卵管超声造影在评价输卵管妊娠治疗后通畅性中的作用[J].临床超声医学杂志,2018,20(8):543-546.
[21] 蒙金华,赵 丹,彭远兰,等.血清β-HCG、P、CA125检测对输卵管妊娠的诊断价值[J].医学临床研究,2019,36(6):1218-1220.

相似文献/References:

[1]陈 爽.不同彩色多普勒超声检查方式在异位妊娠早期诊断中的应用研究[J].陕西医学杂志,2020,49(2):154.
　CHEN Shuang..Application of different color Doppler ultrasonography in early diagnosis of ectopic pregnancy[J].,2020,49(5):154.

备注/Memo

备注/Memo:
基金项目:陕西省重点研发计划项目(2020SF-105)
更新日期/Last Update: 2022-05-05