[1]冯雪燕,邱洪涛,王剑鹰,等.Bakri球囊联合马来酸麦角新碱对产后出血患者应激反应及凝血功能的影响[J].陕西医学杂志,2022,51(5):591-594.[doi:DOI:10.3969/j.issn.1000-7377.2022.05.018]
　FENG Xueyan,QIU Hongtao,WANG Jianying,et al.Effect of Bakri balloon combined with ergometrine maleate on stress response and coagulation function in patients with postpartum hemorrhage[J].,2022,51(5):591-594.[doi:DOI:10.3969/j.issn.1000-7377.2022.05.018]
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Bakri球囊联合马来酸麦角新碱对产后出血患者应激反应及凝血功能的影响
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《陕西医学杂志》[ISSN:1000-7377/CN:61-1281/TN]

卷:
51
期数:
2022年5期
页码:
591-594
栏目:
药物与临床
出版日期:
2022-05-05

文章信息/Info

Title:
Effect of Bakri balloon combined with ergometrine maleate on stress response and coagulation function in patients with postpartum hemorrhage
作者:
冯雪燕; 邱洪涛; 王剑鹰; 刘 晶; 薛轶乔; 赵 平; 刘朝阳; 刘英洁
(西北妇女儿童医院,陕西 西安 710061)
Author(s):
FENG Xueyan; QIU Hongtao; WANG Jianying; LIU Jing; XUE Yiqiao; ZHAO Ping; LIU Zhaoyang; LIU Yingjie
(Northwest Women's and Children's Hospital,Xi'an 710061,China)
关键词:
产后出血;  治疗;  Bakri球囊;  马来酸麦角新碱;  应激反应;  凝血功能
Keywords:
Postpartum hemorrhage;  Treatment;  Bakri balloon;  Ergometrine maleate;  Stress reaction;  Coagulation function
分类号:
R 714.46
DOI:
DOI:10.3969/j.issn.1000-7377.2022.05.018
文献标志码:
A
摘要:
目的:分析Bakri子宫填塞球囊导管(Bakri球囊)联合马来酸麦角新碱对产后出血患者应激反应及凝血功能的影响。方法:选取82例产后出血患者,分为研究组和对照组各41例。对照组患者注射马来酸麦角新碱,研究组注射马来酸麦角新碱并将Bakri球囊末端塞入阴道或在剖宫产术中子宫切口位置。对比两组产妇出血情况; 对比两组产妇一氧化氮(NO)、一氧化氮合酶(NOS)指标水平; 对比两组产妇肾素、肾上腺素、血管紧张素Ⅱ、去甲肾上腺素水平; 对比两组产妇凝血酶原时间(PT)、活化部分凝血活酶时间(APTT)、D-二聚体(D-D)、纤维蛋白原(Fbg)水平; 对比两组产妇临床疗效。结果:两组产后2 h出血量对比差异无统计学意义(P>0.05),2～24 h研究组出血量明显少于对照组(P<0.05); 两组治疗前NO、NOS比较差异无统计学意义(均P>0.05),治疗后NO、NOS水平下降,且研究组低于对照组(P<0.05); 研究组产妇肾素、血管紧张素Ⅱ、去甲肾上腺素、肾上腺素水平明显低于对照组(均P<0.05); 两组治疗前PT、APTT、D-D、Fbg水平对比差异无统计学意义(均P>0.05),治疗后PT、APTT、D-D水平下降,Fbg水平上升,且研究组变化幅度较大(均P<0.05); 治疗后研究组临床疗效明显高于对照组(P<0.05)。结论:Bakri球囊联合马来酸麦角新碱治疗减少了产后出血量,降低了血清生化指标、应激指标、PT、APTT、D-D升高了Fbg,临床疗效显著。
Abstract:
Objective:To analyze the effect of Bakri uterine tamponade balloon catheter(Bakri balloon)combined with ergonovine maleate on the stress response and coagulation function of patients with postpartum hemorrhage.Methods: Eighty-two patients with ostpartum hemorrhage were selected and divided into study group and control group,41 patients in each.Patients in control group were injected with ergonovine maleate,while patients in study group were injected with ergonovine maleate and the end of Bakri balloon was inserted into the vagina or treated by uterine incision during cesarean section.The levels of nitric oxide(NO),nitric oxide synthase(NOS),renin,epinephrine,angiotensin Ⅱ and norepinephrine,prothrombin time(PT),activated partial thromboplastin time(APTT),D-dimer(D-D),fibrinogen(Fbg)and clinical effects were compared between two groups.Results:There was no statistical difference in the blood loss level between the two groups at 2 hours postpartum(P>0.05).The blood loss in study group from 2 to 24 hours was significantly less than that in control group(P<0.05).There was no significant difference in NO and NOS between the two groups before treatment(all P>0.05),but the levels of NO and NOS decreased after treatment,and the study group was lower than the control group(all P<0.05).The levels of renin,angiotensin Ⅱ,norepinephrine and epinephrine in study group were significantly lower than those in control group(all P<0.05).There was no significant difference in the levels of PT,APTT,D-D and Fbg between the two groups before treatment(all P>0.05).After treatment,the levels of PT,APTT and D-D decreased,while Fbg increased,and the change of the study group was larger(all P<0.05).The clinical efficacy of the study group was significantly higher than that of the control group(P<0.05).Conclusion:The combination of Bakri balloon and ergonovine maleate can reduce the amount of postpartum hemorrhage,reduce serum biochemical indexes,stress indexes,PT,APTT,D-D and increase Fbg.

参考文献/References:

[1] 陈阳阳,高 慧.产后出血液体复苏的研究进展[J].实用妇产科杂志,2021,37(1):28-31.
[2] Birch S,Lu C.Ergometrine-induced atrial fibrillation at caesarean section[J].BMJ Case Rep,2019,12(2):226747.
[3] Said AA,Faraag E,Mohammed M,et al.The safety and effectiveness of Bakri balloon in the management of postpartum hemorrhage:A systematic review[J].J Matern Fetal Neonatal Med,2021,34(2):300-307.
[4] Crawford RA,Pavitt GD.Translational regulation in response to stress in saccharomyces cerevisiae[J].Yeast,2019,36(1):5-21.
[5] Jin X,Duan Y,Bao T,et al.The values of coagulation function in COVID-19 patients[J].PLoS One,2020,15(10):241329.
[6] 中华医学会妇产科学分会产科学组.产后出血预防与处理指南(2014)[J].中国实用乡村医生杂志,2015,23(10):8-11.
[7] Higgins N,Patel SK,Toledo P.Postpartum hemorrhage revisited:New challenges and solutions[J].Curr Opin Anaesthesiol,2019,32(3):278-284.
[8] 刘小艳,常 青,陈 丹,等.大量产后出血的危险因素分析[J].重庆医学,2021,50(3):428-431.
[9] 王 静,陈 阳.马来酸麦角新碱辅助治疗剖宫产产后出血的疗效及安全性[J].贵州医药,2021,45(9):1423-1424.
[10] 罗沛芬,陈小兰,黄 文.Bakri球囊填塞治疗剖宫产产后出血效果及对凝血功能影响[J].中国计划生育学杂志,2021,29(8):1736-1740.
[11] 齐 辉.临床护理路径在妊高征产妇产后出血护理中的应用及对出血量的影响[J].国际护理学杂志,2021,40(18):3421-3424.
[12] 马 丽,陈 雄,陈琪珍,等.NO、NOS、BNP水平变化与剖宫产后出血的关系研究[J].浙江医学,2021,43(23):2543-2546.
[13] 何佳佳,漆洪波,邓 娜,等.产后出血的危险因素及血清AT-Ⅲ、BNP、NO对其预测价值探讨[J].中国性科学,2020,29(3):85-89.
[14] 马春莲,乔发敏.改良B-Lynch缝合联合缩宫素治疗产后出血的疗效及对产妇血清NO、NOS、BNP的影响[J].湖南师范大学学报:医学版,2020,17(3):153-156.
[15] 包春燕,卢白玉,徐 郁,等.卡前列素氨丁三醇联合卡贝缩宫素对剖宫产后出血患者NO、NOS、FIB、D-dimer及泌乳功能的影响[J].中国妇幼保健,2019,34(8):1764-1767.
[16] 关文洁,聂岸柳,苏湘芬,等.新冠肺炎流行期急诊护士心理应激反应及相关因素[J].中国心理卫生杂志,2021,35(1):73-78.
[17] 靳健美,肖 琳,胡又丹.子宫动脉栓塞术治疗前置胎盘剖宫产产后出血对患者应激反应及性激素的影响[J].中国计划生育学杂志,2021,29(8):1741-1744,1748.
[18] 张 明,王 瑾,王 睿,等.替加环素致凝血功能障碍文献分析[J].中国新药杂志,2021,30(3):285-288.
[19] 李晓莹,赵玉虹,郝一文.不同凝血指标在胃癌患者凝血功能中的应用评价[J].中国医科大学学报,2021,50(7):602-607.
[20] 谢 晖,沈 瀚.慢性肾脏病患者凝血功能变化及高凝状态影响因素分析[J].检验医学,2021,36(5):500-503.

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备注/Memo

备注/Memo:
基金项目:陕西省重点研发计划项目(2018SF-064)
更新日期/Last Update: 2022-05-05