[1]王 萍,王文娟,杜 翔.慢性肾脏病患者肾素-血管紧张素系统与血浆β-淀粉样蛋白相关性研究[J].陕西医学杂志,2022,51(5):574-577,590.[doi:DOI:10.3969/j.issn.1000-7377.2022.05.014]
　WANG Ping,WANG Wenjuan,DU Xiang.Correlation between renin-angiotensin system and plasma beta-amyloid peptide in patients with chronic kidney disease and its significance[J].,2022,51(5):574-577,590.[doi:DOI:10.3969/j.issn.1000-7377.2022.05.014]
点击复制

慢性肾脏病患者肾素-血管紧张素系统与血浆β-淀粉样蛋白相关性研究
分享到：

《陕西医学杂志》[ISSN:1000-7377/CN:61-1281/TN]

卷:
51
期数:
2022年5期
页码:
574-577,590
栏目:
临床研究
出版日期:
2022-05-05

文章信息/Info

Title:
Correlation between renin-angiotensin system and plasma beta-amyloid peptide in patients with chronic kidney disease and its significance
作者:
王 萍; 王文娟; 杜 翔
(咸阳市中心医院,陕西 咸阳 712000)
Author(s):
WANG Ping; WANG Wenjuan; DU Xiang
(Xianyang Central Hospital,Xianyang 712000,China)
关键词:
慢性肾脏病;  阿尔茨海默病;  肾素-血管紧张素系统;  血管紧张素Ⅱ;  β-淀粉样蛋白;  相关性
Keywords:
Chronic kidney disease;  Alzheimer's disease;  Renin-angiotensin system;  AngiotensinⅡ;  Beta-amyloid peptide;  Correlation
分类号:
R 692
DOI:
DOI:10.3969/j.issn.1000-7377.2022.05.014
文献标志码:
A
摘要:
目的:分析慢性肾脏病(CKD)患者肾素-血管紧张素系统(RAS)与血浆β-淀粉样蛋白(Aβ)的相关性,进而探究CKD与阿尔茨海默病(AD)的关系。方法:收集CKD患者33例(CKD组)、年龄及性别相当的健康体检者35例(对照组)为研究对象。记录所有研究对象一般临床资料(包括性别、年龄)、生活方式(包括饮酒、吸烟)、共病(包括高血压、糖尿病)以及实验室检查指标(包括肌酐、尿素氮、二氧化碳、尿酸、胱抑素C)。检测血浆肾素、血管紧张素Ⅱ、Aβ1-40、Aβ1-42水平并计算Aβ1-40/Aβ1-42。采用多重线性回归分析CKD患者各项指标与血浆Aβ的相关性。结果:两组年龄与性别,以及吸烟、饮酒、糖尿病情况,二氧化碳水平比较,差异无统计学意义(均P>0.05)。CKD组高血压患病数高于对照组(P<0.05)。CKD组肾素、血管紧张素Ⅱ、肌酐、尿素氮、尿酸、胱抑素C水平均高于对照组(均P<0.05)。CKD组Aβ1-40和Aβ1-42水平高于对照组,Aβ1-40/Aβ1-42低于对照组(均P<0.05)。CKD患者血管紧张素Ⅱ与Aβ1-40、Aβ1-40/A1-42呈负相关,与Aβ1-42呈正相关(均P<0.05); 胱抑素C与Aβ1-40、Aβ1-40/A1-42呈正相关(均P<0.05); 肌酐与Aβ1-40/Aβ1-42呈正相关性(P<0.05)。结论:CKD患者RAS与血浆Aβ存在相关性,而Aβ沉积为AD的主要病理学特征,故CKD与AD密切相关。
Abstract:
Objective:To study the correlation between renin-angiotensin system and plasma beta-amyloid peptide(Aβ)in patients with chronic kidney disease(CKD),and to explore the relationship between CKD and Alzheimer's disease(AD).Methods: 33 CKD patients(CKD group)and 35 healthy subjects of the same age and sex(control group)were collected as study subjects.General clinical data(including gender,age),lifestyle(including alcohol consumption,smoking),comorbidities(including hypertension,diabetes),and laboratory tests(including creatinine,urea nitrogen,carbon dioxide,uric acid,and cystatin C)were recorded for all subjects.Plasma levels of renin,angiotensin Ⅱ,Aβ1-40 and Aβ1-42 were measured and Aβ1-40/Aβ1-42 was calculated.Multiple linear regression was used to analyze the correlation between various indexes and plasma Aβ in CKD patients.Results:There was no significant difference between the two groups in terms of age,sex,smoking,alcohol consumption and diabetes mellitus(all P>0.05).The prevalence of hypertension in CKD group was higher than that in control group(P<0.05).The levels of renin,angiotensin Ⅱ,creatinine,urea nitrogen,uric acid and cystatin C in CKD group were higher than those in control group(all P<0.05).The levels of Aβ1-40 and Aβ1-42 in CKD group were higher than those in control group,and Aβ1-40/Aβ1-42 was lower than that in control group(all P<0.05).Angiotensin Ⅱ was negatively correlated with Aβ1-40 and Aβ1-40/A1-42 and positively correlated with Aβ1-42 in CKD patients(all P<0.05).Cystatin C was positively correlated with Aβ1-40 and Aβ1-40/A1-42(all P<0.05).Creatinine was positively correlated with Aβ1-40/Aβ1-42(P<0.05).Conclusion:There is a correlation between RAS and plasma Aβ in patients with CKD,and Aβ deposition is the main pathological feature of AD,so CKD is closely related to AD.

参考文献/References:

[1] Reitz C,Mayeux R.Alzheimer disease:Epidemiology,diagnostic criteria,risk factors and biomarkers[J].Biochem Pharmacol,2014,88(4):640-651.
[2] Deture MA,Dickson DW.The neuropathological diagnosis of Alzheimer's disease[J].Molecular Neurodegeneration,2019,14(1):32.
[3] Yuan J,Zhang Z,Wen H,et al.Incidence of dementia and subtypes:Acohort study in four regionsin China[J].Alzheimers Dement,2016,12(3):262-271.
[4] Yeh YC,Kuo YT,Huang MF,et al.Association of brain white matter lesions and atrophy with cognitive function in chronic kidney disease[J].International Journal of Geriatric Psychiatry,2019,12(34):1826-1832.
[5] Kanemaru K,Kanemaru A,Murayama S,et al.Association between renal functions and CSF biomarkers in Alzheimer's disease[J].Alzheimer's Dement,2016,12:60-65.
[6] Patel S,Rauf A,Khan H,et al.Renin-angiotensin-aldosterone(RAAS):The ubiquitous system for homeostasis and pathologies[J].Biomed Pharmacother,2017,94:317-325.
[7] Tian X,Guo X,Xia X,et al.The comparison of cognitive function and risk ofdementia in CKD patients under peritoneal dialysis and hemodialysis:A PRISMA-compliant systematic review and meta-analysis[J].Medicine,2019,98:190-198.
[8] 尚苏杭,曹红梅,屈秋民,等.70岁及以上人群收缩压与认知障碍的相关关系:一项以西安市鄠邑区农村人群为基础的横断面调查[J].西安交通大学学报:医学版,2020,41(6):956-960.
[9] Stanciu GD,Luca A,Rusu RN,et al.Alzheimer's diseasepharmacotherapy in relation to cholinergic system involvement[J].Biomolecules,2020,10:40.
[10] Abiodun OA,Ola MS.Role of brain renin angiotensin system in neurodegeneration:An update[J].Saudi J Biol Sci,2020,27:905-912.
[11] Nanjundaiah S,Chidambaram H,Chandrashekar M,et al.Role of microglia in regulating cholesterol and tau pathology in Alzheimer's disease[J].Cell Mol Neurobiol,2021,41(4):651-668.
[12] Saavedra JM.Beneficial effects of angiotensin Ⅱ receptor blockers in brain disorders[J].Pharmacol Res,2017,125:91-103.
[13] Nakagawa T,Hasegawa Y,Uekawa K,et al.Chronic kidney disease accelerates cognitive impairment in a mousemodel of Alzheimer's disease,through angiotensin Ⅱ[J].Experimental Gerontology,2017,87:108-112.
[14] Mathews PM,Levy E.Cystatin C in aging and in Alzheimer's disease[J].Ageing Res Rev,2016,324:38-50.
[15] 王立媛,王亿平,茅燕萍,等.中药优选方保留灌肠联合高位结肠透析对慢性肾衰湿热证患者 CysC、PTH水平及营养的影响[J].陕西中医,2020,41(7):917-919.
[16] 顾 雪,樊英华,张 莉,等.尿毒清保留灌肠对CKD 3～4期患者血清Cys-C清除的临床观察[J].陕西中医,2015,36(7):856-857.
[17] Duan J,Macellus KA,Qjn X,et al.Cystatin C promotes tau protein phosphorylation and causes microtubule instability by inhibiting intracellular tumover of GSK3β in neurons[J].Mol Cell Neurosci,2018,89:1-8.
[18] 郭晓聪,殷明刚,徐晓娅,等.不同病程阿尔茨海默病患者尿液中AD7C-NTP含量的研究[J].陕西医学杂志,2018,47(12):1606-1608.
[19] 刘 涛,黄志刚.阿尔茨海默病信号转导机制的研究进展[J].陕西医学杂志,2012,41(6):742-743.
[20] 张 赫,郑 焱.β淀粉样蛋白级联假说相关的阿尔茨海默病发病机制及防治策略研究进展[J].中国医学科学院学报,2019,41(5):702-708.

相似文献/References:

[1]张 泽,韩 锟,贾 宁△.荭草苷对APP/PS1转基因小鼠神经保护作用实验研究*[J].陕西医学杂志,2020,49(5):534.
　ZHANG Ze,HAN Kun,JIA Ning..Neuroprotective effect of orientin on APP/PS1 transgenic mice[J].,2020,49(5):534.
[2]杨 雄,高 伟,邱万胜,等.白蛋白球蛋白比值对慢性肾脏病患者预后判断的价值研究[J].陕西医学杂志,2020,49(6):728.[doi:DOI:10.3969/j.issn.10007377.2020.06.022]
[3]王 丰,李 莎,胡赛琴,等.基于弥散张量成像主观认知下降患者脑效应机制研究进展[J].陕西医学杂志,2022,51(1):117.[doi:DOI:10.3969/j.issn.1000-7377.2022.01.029]
　WANG Feng,LI Sha,HU Saiqin,et al.Research progress of brain effect mechanism in patients with subjective cognitive decline based on diffusion tensor imaging[J].,2022,51(5):117.[doi:DOI:10.3969/j.issn.1000-7377.2022.01.029]
[4]赵 洪,包金平,赵 璐,等.接触蛋白相关蛋白作用研究进展[J].陕西医学杂志,2023,52(9):1272.[doi:DOI:10.3969/j.issn.1000-7377.2023.09.037]
　ZHAO Hong,BAO Jinping,ZHAO Lu,et al.Research progress on role of contactin-associated protein[J].,2023,52(5):1272.[doi:DOI:10.3969/j.issn.1000-7377.2023.09.037]
[5]李梦梦,张淑英,赵艳杰.视黄醇结合蛋白、胱抑素C、胃泌素前体释放肽水平联合超微血流成像在慢性肾脏病诊断中的价值研究[J].陕西医学杂志,2024,(4):483.[doi:DOI:10.3969/j.issn.1000-7377.2024.04.010]
　LI Mengmeng,ZHANG Shuying,ZHAO Yanjie.Diagnostic value of RBP,CysC and proGRP in combination with superb micro-vascular imaging in chronic kidney disease[J].,2024,(5):483.[doi:DOI:10.3969/j.issn.1000-7377.2024.04.010]
[6]方修移,吴小冬,潘美娟,等.罗沙司他治疗慢性肾脏病合并肾性贫血临床价值研究[J].陕西医学杂志,2024,(5):666.[doi:DOI:10.3969/j.issn.1000-7377.2024.05.020]
　FANG Xiuyi,WU Xiaodong,PAN Meijuan,et al.Value of roxadustat in the treatment of chronic kidney disease complicated with renal anemia[J].,2024,(5):666.[doi:DOI:10.3969/j.issn.1000-7377.2024.05.020]

备注/Memo

备注/Memo:
基金项目:陕西省咸阳市重点研发计划项目(2020K02-91)
更新日期/Last Update: 2022-05-05