[1]梁朝鑫,周安远,王 伟,等.骨髓间充质干细胞治疗骨科疾病研究进展[J].陕西医学杂志,2022,51(1):121-124,封3.[doi:DOI:10.3969/j.issn.1000-7377.2022.01.030]
　LIANG Chaoxin,ZHOU Anyuan,WANG Wei,et al.Research progress of bone marrow mesenchymal stem cells in the treatment of orthopedic diseases[J].,2022,51(1):121-124,封3.[doi:DOI:10.3969/j.issn.1000-7377.2022.01.030]
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骨髓间充质干细胞治疗骨科疾病研究进展
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《陕西医学杂志》[ISSN:1000-7377/CN:61-1281/TN]

卷:
51
期数:
2022年1期
页码:
121-124,封3
栏目:
综 述
出版日期:
2022-01-05

文章信息/Info

Title:
Research progress of bone marrow mesenchymal stem cells in the treatment of orthopedic diseases
作者:
梁朝鑫1; 周安远2; 王 伟1; 周 游3; 戈 超3; 高莉鹏3; 李兴勇3; 张 琨3; 雷 云3; 杨 渊4
(1.广西中医药大学,广西 南宁530200; 2.广西医科大学,广西 南宁530021; 3.广西骨伤医院,广西 南宁530012; 4.广西医大开元埌东医院,广西 南宁530028)
Author(s):
LIANG Chaoxin; ZHOU Anyuan; WANG Wei; ZHOU You; GE Chao; GAO Lipeng; LI Xingyong; ZHANG Kun; LEI Yun; YANG Yuan
(Guangxi University of Chinese Medicine,Nanning 530200,China)
关键词:
骨髓间充质干细胞;  骨缺损;  股骨头坏死;  骨关节炎;  脊髓损伤;  软骨;  椎间盘;  进展
Keywords:
Bone marrow mesenchymal stem cells;  Bone defect;  Necrosis of femoral head;  Osteoarthritis;  Spinal cord injury;  Cartilage;  Intervertebral disc;  Progress
分类号:
R 681
DOI:
DOI:10.3969/j.issn.1000-7377.2022.01.030
文献标志码:
A
摘要:
骨髓间充质干细胞具有分化形成软骨细胞、成骨细胞、神经细胞等多向分化潜能,具有促进骨与软组织的修复且取材方便、易于培养的优势,目前已有大量研究显示,其在治疗骨科疾病领域得到了广泛的关注。近年来,骨髓间充质干细胞应用于骨科疾病治疗的基础和临床研究已成为热点,笔者就近年来骨髓间充质干细胞用于治疗骨科疾病的应用现状和疗效做一综述。
Abstract:
Bone marrow mesenchymal stem cells have the potential to differentiate into chondrocytes,osteoblasts and nerve cells,and have the advantages of facilitating bone and soft tissue repair,convenient selection and easy culture.At present,a large number of studies have shown that they have received extensive attention in the field of orthopedic diseases.In recent years,the application of bone marrow mesenchymal stem cells in the treatment of orthopedic diseases has become a focus of basic and clinical research.This paper reviews the application status and efficacy of bone marrow mesenchymal stem cells in the treatment of orthopedic diseases.

参考文献/References:

[1] Friedenstein AJ,Gorskaja JF,Kulagina NN.Fibroblast precursors in normal and irradiated mouse hematopoietic organs[J].Exp Hematol,1976,4(5):267-274.
[2] Hendijani F.Explant culture:An advantageous method for isolation of mesenchymal stem cells from human tissues[J].Cell Proliferation,2017,50(2):e12334.
[3] 蔡金宏,林春博,杨 渊.间充质干细胞分离方法的研究与进展[J].中国组织工程研究,2014,18(45):7375-7380.
[4] Rosca AM,Burlacu A.Isolation of a mouse bone marrow population enriched in stem and progenitor cells by centrifugation on a percoll gradient[J].Biotechnology & Applied Biochemistry,2010,55(4):199-208.
[5] 刘 伟,刘 萌,祝劲松,等.人骨髓间充质干细胞的体外培养、鉴定及成骨分化[J].中国组织工程研究,2012,16(14):2515-2519.
[6] Yagi K,Kojima M,Oyagi S,et al.Application of mesenchymal stem cells to liver regenerative medicine[J].Yakugaku Zasshi Journal of the Pharmaceutical Society of Japan,2008,128(1):3-9.
[7] Vawda R,Fehlings MG.Mesenchymal cells in the treatment of spinal cord injury:Current & future perspectives[J].Current Stem Cell Research & Therapy,2013,8(1):25-38.
[8] Andrzejewska A,Lukomska B,Janowski M.Concise review:Mesenchymal stem cells:From roots to boost[J].Stem Cells(Dayton,Ohio),2019,37(7):855-864.
[9] Watanabe Y,Harada N,Sato K,et al.Stem cell therapy:Is there a future for reconstruction of large bone defects?[J].Injury,2016,47:s47-s51.
[10] Gjerde C,Mustafa K,Hellem S,et al.Cell therapy induced regeneration of severely atrophied mandibular bone in a clinical trial[J].Stem Cell Research & Therapy,2018,9(1):213.
[11] Zhao X,Han XS,Zhou QZ,et al.Repair of bone defects with endothelial progenitor cells and bone marrow-derived mesenchymal stem cells with tissue-engineered bone in rabbits[J].Annals of Plastic Surgery,2020,85(4):430-436.
[12] Oryan A,Eslaminejad MB,Kamali A,et al.Mesenchymal stem cells seeded onto tissue-engineered osteoinductive scaffolds enhance the healing process of critical-sized radial bone defects in rat[J].Cell & Tissue Research,2018,374(1):1-19.
[13] Lawrence LM,Cottrill A,Valluri A,et al.Minimally manipulative method for the expansion of human bone marrow mesenchymal stem cells to treat osseous defects[J].International Journal of Molecular Sciences,2019,20(3):612.
[14] Ruan SQ,Deng J,Yan L,et al.Composite scaffolds loaded with bone mesenchymal stem cells promote the repair of radial bone defects in rabbit model[J].Biomedecine & Pharmacotherapie,2018,97:600-606.
[15] Xu H,Wang C,Liu C,et al.Cotransplantation of mesenchymal stem cells and endothelial progenitor cells for treating steroid-induced osteonecrosis of the femoral head[J].Stem Cells Transl Med,2021,10(5):781-796.
[16] Mardones R,Camacho D,Monsalvo F,et al.Treatment of osteonecrosis of the femoral head by core decompression and implantation of fully functional ex vivo-expanded bone marrow-derived mesenchymal stem cells:A proof-of-concept study[J].Stem Cells and Cloning:Advances and Applications,2019,12:11-16.
[17] Zhao D,Cui D,Wang B,et al.Treatment of early stage osteonecrosis of the femoral head with autologous implantation of bone marrow-derived and cultured mesenchymal stem cells[J].Bone,2012,50(1):325-330.
[18] Wang Z,Sun QM,Zhang FQ,et al.Core decompression combined with autologous bone marrow stem cells versus core decompression alone for patients with osteonecrosis of the femoral head:A meta-analysis[J].International Journal of Surgery(London,England),2019,69:23-31.
[19] Xu Y,Jiang Y,Xia CS,et al.Stem cell therapy for osteonecrosis of femoral head:Opportunities and challenges[J].Regenerative Therapy,2020,15:295-304.
[20] Doyle EC,Wragg NM,Wilson SL.Intraarticular injection of bone marrow-derived mesenchymal stem cells enhances regeneration in knee osteoarthritis[J].Knee Surgery Sports Traumatology Arthroscopy,2020,28(12):3827-3842.
[21] Lamo-Espinosa JM,Mora G,Blanco JF,et al.Intra-articular injection of two different doses of autologous bone marrow mesenchymal stem cells versus hyaluronic acid in the treatment of knee osteoarthritis:Long-term follow up of a multicenter randomized controlled clinical trial(phase Ⅰ/Ⅱ)[J].Journal of Translational Medicine,2018,16(1):213.
[22] Chahal J,Gómez-Aristizábal A,Shestopaloff K,et al.Bone marrow mesenchymal stromal cell treatment in patients with osteoarthritis results in overall improvement in pain and symptoms and reduces synovial inflammation[J].Stem Cells Transl Med,2019,8(8):746-757.
[23] Hernigou P,Bouthors C,Bastard C,et al.Subchondral bone or intra-articular injection of bone marrow concentrate mesenchymal stem cells in bilateral knee osteoarthritis:What better postpone knee arthroplasty at fifteen years? a randomized study[J].International Orthopaedics,2021; 45(2):391-399.
[24] Ackery A,Tator C,Krassioukov A.A global perspective on spinal cord injury epidemiology[J].Neurotrauma,2004,21(10):1355-1370.
[25] Huang XR,Xu H,Zhang Y,et al.Repair effect of bFGF combined with bone marrow mesenchymal stem cells on spinal cord injury in rats[J].Zhongguo Gu Shang,2019,32(7):653-657.
[26] Wang X,Ye L,Zhang K,et al.Upregulation of microRNA-200a in bone marrow mesenchymal stem cells enhances the repair of spinal cord injury in rats by reducing oxidative stress and regulating Keap1/Nrf2 pathway[J].Artificial Organs,2020,44(7):744-752.
[27] Gu J,Jin ZS,Wang CM,et al.Bone marrow mesenchymal stem cell-derived exosomes improves spinal cord function after injury in rats by activating autophagy[J].Drug Design,Development and Therapy,2020,29(14):1621-1631.
[28] Mo C,Ren L,Zhao Z,et al.Effects of bone marrow mesenchymal stem cells transplantation for treating rat spinal cord injury and cytokine expression at injury sites[J].Chinese Journal of Reparative & Reconstructive Surgery,2016,30(3):265.
[29] Wang L,Wang Q,Zhang XM.Progress on bone marrow mesenchymal stem cells transplantation for spinal cord injury[J].China journal of Orthopaedics and Traumatology,2014,27(5):437-440.
[30] 刘军政,张书艳,高建强,等.骨髓间充质干细胞对软骨诱导分化过程中microRNA调控机制[J].陕西医学杂志,2017,46(8):989-919.
[31] Zheng YH,Kai S,Kuang SJ,et al.New bone and cartilage tissues formed from human bone marrow mesenchymal stem cells derived from human condyle in vivo[J].Chinese Journal of Stomatology,2012,47(1):10.
[32] Araki S,Imai S,Ishigaki H,et al.Improved quality of cartilage repair by bone marrow mesenchymal stem cells for treatment of an osteochondral defect in a cynomolgus macaque model[J].Acta Orthopaedica,2015,86(1):119-126.
[33] Ishihara K,Nakayama K,Akieda S,et al.Simultaneous regeneration of full-thickness cartilage and subchondral bone defects in vivo using a three-dimensional scaffold-free autologous construct derived from high-density bone marrow-derived mesenchymal stem cells[J].Journal of Orthopaedic Surgery and Research,2014,14,(9):98.
[34] Windt D,Tommy S,Vonk,et al.Allogeneic mesenchymal stem cells stimulate cartilage regeneration and are safe for single-stage cartilage repair in humans upon mixture with recycled autologous chondrons[J].Stem Cells,2017,35(1):256-264.
[35] Yong SK,Chung PK,Dong SS,et al.Implantation of mesenchymal stem cells in combination with allogenic cartilage improves cartilage regeneration and clinical outcomes in patients with concomitant high tibial osteotomy[J].Knee Surg Sports Traumatol Arthrosc,2020,28(2):544-554.
[36] Orozco L,Soler R,Morera C,et al.Intervertebral disc repair by autologous mesenchymal bone marrow cells:A pilot study[J].Transplantation,2011,92(7):822-828.
[37] Liao Z,Luo R,Li G,et al.Exosomes from mesenchymal stem cells modulate endoplasmic reticulum stress to protect against nucleus pulposus cell death and ameliorate intervertebral disc degeneration in vivo[J].Theranostics,2019,9(14):4084-4100.
[38] Pettine KA,Murphy MB,Suzuki RK,et al.Percutaneous injection of autologous bone marrow concentrate cells significantly reduces lumbar discogenic pain through 12 months[J].Stem Cells,2015,33(1):146-156.
[39] Noriega DC,Ardura F,Hernandez R,et al.Intervertebral disc repair by allogeneic mesenchymal bone marrow cells:A randomized controlled trial[J].Transplantation,2017,101(8):1945-1951.

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备注/Memo

备注/Memo:
基金项目:广西壮族自治区自然科学基金资助项目(2020GXNSFAA159162)
更新日期/Last Update: 2022-01-09