[1]黄 静,陈佳茹,喻 莹,等.抑癌基因BLU在肿瘤中的作用及分子机制研究进展[J].陕西医学杂志,2021,50(11):1462-封3.[doi:DOI:10.3969/j.issn.1000-7377.2021.11.035]
　HUANG Jing,CHEN Jiaru,YU Ying,et al.Role and molecular mechanism of tumor suppressor gene BLU in tumors[J].,2021,50(11):1462-封3.[doi:DOI:10.3969/j.issn.1000-7377.2021.11.035]
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抑癌基因BLU在肿瘤中的作用及分子机制研究进展
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《陕西医学杂志》[ISSN:1000-7377/CN:61-1281/TN]

卷:
50
期数:
2021年11期
页码:
1462-封3
栏目:
综 述
出版日期:
2021-11-05

文章信息/Info

Title:
Role and molecular mechanism of tumor suppressor gene BLU in tumors
作者:
黄 静1; 陈佳茹2; 喻 莹3; 张湘宁3; 余红兵1
(1.广东医科大学广东省医学分子诊断重点实验室,广东 东莞 523808; 2.广东医科大学药学院,广东 东莞 523808; 3.广东医科大学中美肿瘤所,广东 东莞 523808)
Author(s):
HUANG Jing; CHEN Jiaru; YU Ying; ZHANG Xiangning; YU Hongning
(Guangdong Provincial Key Laboratory of Medical Molecular Diagnosis,Guangdong Medical University,Dongguan 523808,China)
关键词:
BLU基因;  抑癌基因;  抑癌功能;  信号通路;  肿瘤;  研究进展
Keywords:
BLU gene;  Tumor suppressor gene;  Tumor suppressor function;  Signal pathway;  Tumor;  Research progress
分类号:
R 735
DOI:
DOI:10.3969/j.issn.1000-7377.2021.11.035
文献标志码:
A
摘要:
BLU是位于3号染色体p21.31 区域的一个重要的抑癌基因,BLU基因主要通过调节NF-κB信号、JNK信号和EPK-RAS-RAF-MEK(细胞外信号激酶)等信号通路来调控细胞周期、诱导细胞凋亡等发挥抑癌作用。BLU基因在许多实体肿瘤中表观遗传失活或者下调,可能原因是BLU启动子甲基化,去甲基化药物治疗后能够内源性恢复BLU基因的表达,恢复正常的抑癌作用。抑癌基因甲基化在肿瘤中经常发生,有望成为肿瘤诊断、预后的标志物和抗肿瘤的治疗靶点。现着重阐述BLU基因的结构、生物学作用、信号传导通路机制以及BLU基因与肿瘤相关性的研究进展。
Abstract:
BLU is an important tumor suppressor gene located in the p21.31 region of chromosome 3.It mainly regulates the cell cycle,induces cell apoptosis,exerts anti-cancer effect through signal pathways such as NF-κB signal,JNK signal and EPK-RAS-RAF-MEK(extracellular signal kinase).The BLU gene is epigenetically inactivated or down-regulated in many solid tumors.The possible cause is the methylation of the BLU promoter.After treatment with demethylation drugs,the BLU gene expression can be restored endogenously and normal tumor suppressor effects can be restored.Tumor suppressor gene methylation often occurs in tumors and is expected to become a marker for tumor diagnosis and prognosis and a target for anti-tumor therapy.This article focuses on the research progress of BLU gene structure,biological function,signal transduction pathway mechanism and the correlation between BLU gene and tumor.

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备注/Memo

备注/Memo:
基金项目:广东医科大学科研启动基金资助项目(4SG21231G,4SG18001Gc,4SG19003Gq)
更新日期/Last Update: 2021-11-05