[1]杨 翰,李爱芳,张永峰,等.结核性脑膜炎分子诊断研究进展[J].陕西医学杂志,2021,50(11):1457-1461.[doi:DOI:10.3969/j.issn.1000-7377.2021.11.034]
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结核性脑膜炎分子诊断研究进展
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《陕西医学杂志》[ISSN:1000-7377/CN:61-1281/TN]

卷:
50
期数:
2021年11期
页码:
1457-1461
栏目:
综 述
出版日期:
2021-11-05

文章信息/Info

作者:
杨 翰李爱芳张永峰党丽云任 斐杨元利
(西安市胸科医院,陕西 西安 710100)
关键词:
结核性脑膜炎 诊断 实时荧光定量聚合酶链式反应 杂交技术 基因测序技术 核酸质谱技术
分类号:
R 529.3
DOI:
DOI:10.3969/j.issn.1000-7377.2021.11.034
文献标志码:
A
摘要:
结核性脑膜炎具有较高的致残率和病死率。结核性脑膜炎的非病原学检测技术仅能做出辅助诊断,无法达到病原学金标准的水平。50%以上的患者很难使用常规方法在脑脊液中分离出结核分枝杆菌。基于基因检测技术的分子学方法对脑脊液中鉴别结核分枝杆菌及耐药分析快速检测已经成为一种重要手段,同时能够解决常规培养、药敏检测中阳性率不高及检测时间长的问题。现就结核性脑膜炎分子诊断研究进展综述如下。

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备注/Memo

备注/Memo:
基金项目:陕西省重点研发计划项目(2020SF-109)
更新日期/Last Update: 2021-11-05