[1]叶骉飞,王童非,张双燕,等.pT1N0M0期乳腺癌患者术后10年后首次出现复发转移相关因素分析[J].陕西医学杂志,2021,50(11):1395-1399.[doi:DOI:10.3969/j.issn.1000-7377.2021.11.018]
 YE Biaofei,WANG Tongfei,ZHANG Shuangyan,et al.Related factors of first recurrence and metastasis of breast cancer patients with pT1N0M0 10 years after mastectomy[J].,2021,50(11):1395-1399.[doi:DOI:10.3969/j.issn.1000-7377.2021.11.018]
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pT1N0M0期乳腺癌患者术后10年后首次出现复发转移相关因素分析
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《陕西医学杂志》[ISSN:1000-7377/CN:61-1281/TN]

卷:
50
期数:
2021年11期
页码:
1395-1399
栏目:
临床研究
出版日期:
2021-11-05

文章信息/Info

Title:
Related factors of first recurrence and metastasis of breast cancer patients with pT1N0M0 10 years after mastectomy
作者:
叶骉飞1王童非1张双燕1李海涛1代 丽2
(1.西安市第三医院 西北大学附属医院,陕西 西安710016; 2.长安医院,陕西 西安710016)
Author(s):
YE BiaofeiWANG TongfeiZHANG ShuangyanLI HaitaoDAI Li
(Xi'an Third Hospital,Xi'an 710016,China)
关键词:
乳腺肿瘤 复发 转移 危险因素 肿瘤分期 分化程度
Keywords:
Breast neoplasms Recurrence Metastasis Risk factor Neoplasm staging Degree of differentiation
分类号:
R 737.9
DOI:
DOI:10.3969/j.issn.1000-7377.2021.11.018
文献标志码:
A
摘要:
目的:探讨pT1N0M0期乳腺癌患者手术后10年后首次出现复发转移的相关因素。方法:收集pT1N0M0期乳腺癌根治术后229例患者的临床病理资料,其中术后10年后首次出现复发转移的患者83例,采用Cox回归分析其复发转移的影响因素。结果:术后10年后首次出现复发转移的pT1N0M0期乳腺癌患者多见于>40岁、雌激素受体/孕激素受体(ER/PR)阳性、人表皮生长因子受体-2(HER2)阴性和Luminal分子亚型; 术后10年后首次出现复发转移的83例患者的中位无瘤生存期(DFS)为157个月,pT1a、pT1b和pT1c的中位DFS分别为:172、159、152个月,pT1a和pT1c比较有统计学差异(t=2.494,P=0.016); 在单因素分析中,年龄、T分期、分化程度、ER/PR状态、HER2状态、Ki-67指数、分子亚型与术后10年后首次出现复发转移患者的DFS相关; 多因素分析显示,年龄、T分期、ER/PR状态、分子亚型均是影响术后10年后首次出现复发转移患者的DFS独立因素(均P<0.05)。结论:pT1N0M0期乳腺癌患者预后相对较好,年轻、肿瘤直径在1~2 cm、激素受体阴性、HER2过表达和三阴性亚型患者复发转移较早,应成为术后10年重点关注对象。
Abstract:
Objective:To investigate the related factors of the first recurrence and metastasis of breast cancer patients with pT1N0M0 10 years after mastectomy.Methods:he clinicopathological data of 229 pT1N0M0 breast cancer patients who underwent mastectomy were collected.Among them,83 patients had the first recurrence and metastasis 10 years after mastectomy.Cox regression was used to analyze the influencing factors of their recurrence and metastasis.Results:pT1N0M0 breast cancer patients with the first recurrence and metastasis 10 years after mastectomy were mostly >40 years old,ER/PR positive,HER2 negative and Luminal subtypes.The median DFS of them was 157 months,among them,the median DFS of pT1a,pT1b and pT1c were 172,159 and 152 months,respectively,and there was significant difference between pT1a and pT1c(t=2.494,P=0.016).Univariate analysis showed that age,T stage,degree of differentiation,ER/PR status,HER2 status,Ki-67 index and molecular subtype were correlated with the DFS of patients with the first recurrence and metastasis 10 years after surgery.Multivariate analysis showed that age,T stage,ER/PR status,and molecular subtype were independent factors affecting the DFS of patients with the first recurrence and metastasis 10 years after surgery(all P<0.05).Conclusion:Patients with pT1N0M0 breast cancer have a good prognosis.Young,tumor diameter of 1-2 cm,hormone receptor-negative,HER2 overexpression and triple negative subtypes patients had earlier recurrence and metastasis,which shall be the focus of attention in the 10 years after mastectomy.

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备注/Memo

备注/Memo:
基金项目:陕西省重点研发计划项目(2019SF-051)
更新日期/Last Update: 2021-11-05