[1]吴 蕾,方 圆,吴 朔,等.某三甲医院住院肺炎患者下呼吸道病原体流行病学特征分析[J].陕西医学杂志,2021,50(10):1299-1302.[doi:DOI:10.3969/j.issn.1000-7377.2021.10.032]
　WU Lei,FANG Yuan,WU Shuo,et al.Epidemiological characteristics of pathogens in the lower respiratory tract of hospitalized patients with pneumonia in a tertiary A hospital[J].,2021,50(10):1299-1302.[doi:DOI:10.3969/j.issn.1000-7377.2021.10.032]
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某三甲医院住院肺炎患者下呼吸道病原体流行病学特征分析
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《陕西医学杂志》[ISSN:1000-7377/CN:61-1281/TN]

卷:
50
期数:
2021年10期
页码:
1299-1302
栏目:
调查研究
出版日期:
2021-10-05

文章信息/Info

Title:
Epidemiological characteristics of pathogens in the lower respiratory tract of hospitalized patients with pneumonia in a tertiary A hospital
作者:
吴 蕾; 方 圆; 吴 朔; 巨 清; 吕 行; 郭晓雅; 屈朔瑶; 张 芳; 陈 佩; 赵 峰
(空军军医大学西京医院呼吸与危重症医学科,陕西 西安 710032 )
Author(s):
WU Lei; FANG Yuan; WU Shuo; JU Qing; LYU Xing; GUO Xiaoya; QU Shuoyao; ZHANG Fang; CHEN Pei; ZHAO Feng
(Department of Respiratory and Critical Care Medicine, Xijing Hospital of Air Force Medical University,Xi'an 710032,China)
关键词:
支气管肺泡灌洗液;  诱导痰;  人冠状病毒;  肺炎克雷伯杆菌;  肺炎支原体
Keywords:
Bronchoalveolar lavage fluid;  Induced sputum;  Human coronavirus;  Klebsiella pneumoniae;  Mycoplasma pneumoniae
分类号:
R 56
DOI:
DOI:10.3969/j.issn.1000-7377.2021.10.032
文献标志码:
A
摘要:
目的:分析住院肺炎患者下呼吸道病原体流行病学特征。方法:采集2018年53例肺炎患者的支气管肺泡灌洗液及诱导痰标本,用Bio-Rad荧光定量PCR 检测病原体。结果:病原体检出率54.72%,病毒检出率33.96%,其中人冠状病毒和人鼻病毒检出率分别为18.87%和15.09%,高于其他病毒; 细菌检出率26.42%,其中肺炎克雷伯杆菌检出率11.32%,高于其他细菌; 肺炎支原体检出率15.09%; 混合病原体检出率24.53%,其中合并肺炎支原体混合感染占46.15%,细菌合并病毒混合感染占30.77%。各年龄段、各季节病原体阳性率比较,差异无统计学意义(均P>0.05)。结论:住院肺炎患者单一病原体感染比例较高,人冠状病毒、人鼻病毒及肺炎支原体、肺炎克雷伯杆菌是主要的感染源,混合感染多以肺炎支原体为主。
Abstract:
Objective:To analyze the epidemiological characteristics of lower respiratory tract pathogens in hospitalized patients with pneumonia.Methods:Bronchoalveolar lavage fluid and induced sputum samples from 53 patients with pneumonia were collected,and the pathogens were detected by Bio-Rad fluorescence quantitative PCR.Results:The detection rates of pathogens and viruses were 54.72% and 33.96%,respectively.The detection rates of human coronavirus and human rhinovirus were 18.87% and 15.09%,respectively,which were higher than other viruses.The detection rate of bacteria was 26.42%,and the detection rate of klebsiella pneumoniae was 11.32%,which was higher than other bacteria.The detection rate of mycoplasma pneumoniae was 15.09%.The detection rate of mixed pathogen was 24.53%,of which the mixed infection with mycoplasma pneumoniae accounted for 46.15%,and the mixed infection with bacteria and viruses accounted for 30.77%.There was no significant difference in the positive rate of pathogens among different ages and seasons.Conclusion:The infection rate of single pathogen in hospitalized patients with pneumonia is high,human coronavirus,human rhinovirus,mycoplasma pneumoniae,klebsiella pneumoniae are the main infectious agents,and mycoplasma pneumoniae is the main mixed infection.

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备注/Memo

备注/Memo:
基金项目:国家科技重大专项计划项目(2017ZX10103004)
更新日期/Last Update: 2021-10-08