[1]余 倩,郭金珍.儿童广泛性发育障碍影响因素及其与新生儿高胆红素血症相关性分析[J].陕西医学杂志,2021,50(9):1090-1093.[doi:DOI:10.3969/j.issn.1000-7377.2021.09.012]
　YU Qian,GUO Jinzhen.Influencing factors of children's pervasive developmental disorder and its correlation with neonatal hyperbilirubinemia[J].,2021,50(9):1090-1093.[doi:DOI:10.3969/j.issn.1000-7377.2021.09.012]
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儿童广泛性发育障碍影响因素及其与新生儿高胆红素血症相关性分析
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《陕西医学杂志》[ISSN:1000-7377/CN:61-1281/TN]

卷:
50
期数:
2021年9期
页码:
1090-1093
栏目:
临床研究
出版日期:
2021-09-05

文章信息/Info

Title:
Influencing factors of children's pervasive developmental disorder and its correlation with neonatal hyperbilirubinemia
作者:
余 倩; 郭金珍
(西北妇女儿童医院,陕西 西安 710061)
Author(s):
YU Qian; GUO Jinzhen
(Northwest Women's and Children's Hospital,Xi'an 710061,China)
关键词:
广泛性发育障碍;  高胆红素血症;  相关性;  儿童;  生育年龄;  影响因素
Keywords:
ervasive developmental disorder;  Hyperbilirubinemia;  Correlation;  Child;  Childbearing age;  Influencing factors
分类号:
R 749.94
DOI:
DOI:10.3969/j.issn.1000-7377.2021.09.012
文献标志码:
A
摘要:
目的:探究儿童广泛性发育障碍(PDD)影响因素,分析其与新生儿高胆红素血症的相关性。方法:选取87例PDD患儿作为PDD组。按照1:1病例对照研究要求,随机从本市幼儿园、小学中选取87例同年龄且性别匹配的健康儿童作为对照组。比较两组儿童孤独症评定量表(CARS)评分和孤独症行为评定量表(ABC)评分。采用Logistic回归分析PDD发生影响因素,并探究PDD发生与新生儿高胆红素血症的相关性。结果:PDD组儿童ABC、CARS评分高于对照组(均P<0.05)。Logistic回归分析显示,新生儿高胆红素血症、父亲生育年龄>35岁、父亲性格内向、有家族史、母亲生育年龄>35岁、主要看护人为(外)祖父母是影响PDD发生的独立危险因素(均P<0.05)。随着胆红素水平升高,PDD发生率亦呈上升趋势,两者具有相关性(P<0.05)。结论:新生儿高胆红素血症、父亲生育年龄>35岁、父亲性格内向、有家族史、母亲生育年龄>35岁、主要看护人为(外)祖父母是影响PDD发生的独立危险因素,且胆红素水平越高,出现PDD的可能性越大。
Abstract:
Objective:To explore the influencing factors of children's pervasive developmental disorder(PDD)and analyze its correlation with neonatal hyperbilirubinemia.Methods:87 children with PDD were selected as the PDD group.87 healthy children of the same age and sex-matched were selected as the control group.The CARS and ABC scores were compared between the two groups.Logistic regression was used to analyze the influencing factors of PDD,and to explore the correlation between PDD and neonatal hyperbilirubinemia.Results:The scores of ABC and CARS in the PDD group were significantly higher than those in the control group(all P<0.05).Logistic regression analysis showed that neonatal hyperbilirubinemia,father's childbearing age >35 years old,father's introverted personality,family history,mother's childbearing age >35 years old,and the main caregiver(external)being grandparents were independent risks for the occurrence of PDD(all P<0.05).As the level of bilirubin increased,the incidence of PDD also showed an upward trend,and the two were correlated(P<0.05).Conclusion:Neonatal hyperbilirubinemia,father's childbearing age >35 years old,father's introverted personality,family history,mother's childbearing age >35 years old,and the main caregiver(external)being grandparents are independent risks for the occurrence of PDD.The higher the bilirubin level,the greater the possibility of PDD.

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备注/Memo

备注/Memo:
基金项目:陕西省重点研发计划项目(2018SF-070)
更新日期/Last Update: 2021-09-06