[1]安 欣,曹 晋,王成凯.正常范围内游离甲状腺素水平与2型糖尿病患者颈动脉粥样硬化相关性探讨[J].陕西医学杂志,2021,50(8):958-961.[doi:DOI:10.3969/j.issn.1000-7377.2021.08.014]
　AN Xin,CAO Jin,WANG Chengkai.Relationship between free thyroxine in normal range and carotid atherosclerosis in patients with type 2 diabetes mellitus[J].,2021,50(8):958-961.[doi:DOI:10.3969/j.issn.1000-7377.2021.08.014]
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正常范围内游离甲状腺素水平与2型糖尿病患者颈动脉粥样硬化相关性探讨
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《陕西医学杂志》[ISSN:1000-7377/CN:61-1281/TN]

卷:
50
期数:
2021年8期
页码:
958-961
栏目:
临床研究
出版日期:
2021-08-05

文章信息/Info

Title:
Relationship between free thyroxine in normal range and carotid atherosclerosis in patients with type 2 diabetes mellitus
作者:
安 欣1; 曹 晋2; 王成凯3
(1.西安工会医院,陕西 西安710100; 2.空军第九八六医院,陕西 西安710054; 3.铜川市人民医院,陕西 铜川727100)
Author(s):
AN Xin; CAO Jin; WANG Chengkai
(Xi'an Trade Union Hospital,Xi'an 710100,China)
关键词:
甲状腺激素;  游离甲状腺素;  2型糖尿病;  颈动脉粥样硬化;  颈动脉内膜中层厚度;  相关性
Keywords:
Thyroid hormone;  Free thyroxine;  Type 2 diabetes mellitus;  Carotid atherosclerosis;  Carotid intima-media thickness;  Correlation
分类号:
R 587.1
DOI:
DOI:10.3969/j.issn.1000-7377.2021.08.014
文献标志码:
A
摘要:
目的:探讨正常范围内游离甲状腺素(FT4)与2型糖尿病患者颈动脉粥样硬化(CAS)的相关性。方法:收集2型糖尿病患者168例,依据颈动脉内膜中层厚度(cIMT)分为CAS组(cIMT≥1.0 mm,n=92例)和非CAS组(cIMT<1.0 mm,n=76例)。记录两组患者一般资料,采用Logistic回归分析各个指标与CAS的关系。结果:CAS组年龄、病程、甘油三酯(TG)、血肌酐、胰岛素抵抗指数(HOMA-IR)均大于或高于非CAS组,差异均有统计学意义(均P<0.05)。CAS组血清FT4水平 [(16.20±1.10)pmol/L]显著低于非CAS组[(17.65±1.23)pmol/L],差异有统计学意义(P<0.05)。Pearson相关性分析显示cIMI与年龄、病程、TG、血肌酐、HOMA-IR呈正相关(P<0.05),而与FT4呈负相关(P<0.05)。多因素Logistic回归分析显示低水平FT4是2型糖尿病患者颈动脉粥样硬化的独立危险因素(P<0.05)。结论:正常范围内的FT4水平降低与2型糖尿病患者颈动脉粥样硬化密切相关,可能是其发生的独立危险因素,临床应加强对血清FT4的监测,有助于识别糖尿病发生CAS的高危患者。
Abstract:
Objective:To investigate the relationship between free thyroxine(FT4)in normal range and carotid atherosclerosis(CAS)in patients with type 2 diabetes mellitus.Methods:According to the carotid intima-media thickness(cIMT),168 patients with type 2 diabetes were divided into CAS group(CIMT≥1.0 mm,n=92)and non-CAS group(CIMT<1.0 mm,n=76).The general clinical data of the two groups were recorded,and the relationship between each laboratory index and CAS was analyzed by Logistic regression.Results:The age,course of disease,triglyceride(TG),serum creatinine,HOMA-IR of CAS group were higher than those of non-CAS group(all P<0.05).The serum FT4 level in CAS Group was significantly lower than that in non-CAS Group(P<0.05).Pearson correlation analysis showed that CIMI was positively correlated with age,course of disease,TG,serum creatinine,HOMA-IR(all P<0.05),but negatively correlated with FT4(P<0.05).Multivariate Logistic regression analysis showed that low level of FT4 was an independent risk factor for CAS in patients with type 2 diabetes mellitus(P<0.05).Conclusion:Low level of FT4 in normal range is closely related to CAS in patients with type 2 diabetes mellitus,which may be an independent risk factor for CAS.Clinical detection of serum FT4 should be strengthened to identify high-risk patients with CAS in diabetes mellitus.

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备注/Memo

备注/Memo:
基金项目:国家重点研发计划精准医学研究重点专项(2016YFC0903100)
更新日期/Last Update: 2021-08-05