[1]薛 涛,郑雪丽.颞侧球结膜眼红指数、眼部症状评分、视觉模拟量表评分在翼状胬肉切除联合自体结膜移植术后眼表炎症状态评价中的应用研究[J].陕西医学杂志,2021,50(6):709-712.[doi:DOI:10.3969/j.issn.1000-7377.2021.06.017]
　XUE Tao,ZHENG Xueli.Application of TCHI,OSS and VAS in evaluation of ocular surface inflammation after pterygium resection combined with conjunctival autograft[J].,2021,50(6):709-712.[doi:DOI:10.3969/j.issn.1000-7377.2021.06.017]
点击复制

颞侧球结膜眼红指数、眼部症状评分、视觉模拟量表评分在翼状胬肉切除联合自体结膜移植术后眼表炎症状态评价中的应用研究
分享到：

《陕西医学杂志》[ISSN:1000-7377/CN:61-1281/TN]

卷:
50
期数:
2021年6期
页码:
709-712
栏目:
临床研究
出版日期:
2021-06-05

文章信息/Info

Title:
Application of TCHI,OSS and VAS in evaluation of ocular surface inflammation after pterygium resection combined with conjunctival autograft
作者:
薛 涛1; 郑雪丽2
(1.咸阳市第一人民医院眼科,陕西 咸阳 712000; 2.咸阳市第一人民医院白内障中心,陕西 咸阳 712000)
Author(s):
XUE Tao; ZHENG Xueli
(Department of Ophthalmology,the First People's Hospital of Xianyang City,Xianyang 712000,China)
关键词:
颞侧球结膜眼红指数;  眼部症状评分;  视觉模拟量表;  翼状胬肉切除;  自体结膜移植术;  眼表炎症
Keywords:
Temporal Conjunctival Hyperemia Index;  Ocular Symptom Score;  Visual Analogue Scale;  Pterygium excision;  Conjunctival autograft;  Ocular surface inflammation
分类号:
R 779.6
DOI:
DOI:10.3969/j.issn.1000-7377.2021.06.017
文献标志码:
A
摘要:
目的:应用颞侧球结膜眼红指数(TCHI)、眼部症状评分(OSS)及视觉模拟量表(VAS)研究翼状胬肉切除联合自体结膜移植术后患者眼表炎症反应变化情况,并将上述指标应用于抗炎治疗效果评价中,判断其应用有效性。方法:以100例翼状胬肉患者为研究对象,均采取翼状胬肉切除联合自体结膜移植术治疗,术后对眼表炎症进行治疗。评估术前,术后1、3、7、10 d,术后1、2个月眼表炎症,应用眼表综合分析仪对TCHI做出评估,观察OSS、VAS评分等主观量化指标的动态变化,采用荧光素钠染色法对角膜上皮愈合情况进行观察,并测量最佳矫正视力(BCVA)。结果:患者术后2个月BCVA明显较术前低(P<0.05)。术后10 d患者角膜无荧光素染色出现,提示角膜上皮缺损愈合完全。术后1 d OSS评分及TCHI值高于术前(均P<0.05); 随着抗炎治疗的开展,患者术后7 d OSS评分及TCHI值均降至术前水平(均P>0.05); 患者术后1、2个月上述指标均较术前低(均P<0.05)。患者术后1 d VAS评分高于术前(P<0.05); 随着抗炎治疗的开展,患者术后7 d VAS评分降至术前水平(P>0.05); 术后2个月VAS评分较术前低(P<0.05)。结论:OSS、VAS评分及TCHI可对行翼状胬肉切除联合自体结膜移植术治疗患者的炎症状态做出有效评估,并可作为抗炎治疗有效性的评价指标。
Abstract:
Objective:To study the changes of ocular surface inflammation after pterygium excision combined with conjunctival autograft by TCHI,OSS and VAS,and to evaluate the efficacy of these indexes in anti-inflammatory treatment.Methods:100 patients with pterygium were taken as research objects.All patients were treated with pterygium resection combined with autologous conjunctival transplantation,and the ocular surface inflammation was treated after the operation.The ocular surface inflammation was evaluated before operation and 1 day,3 days,7 days,10 days,1 month and 2 months after operation.TCHI was evaluated by ocular surface analyzer.The dynamic changes of subjective quantitative indicators such as OSS and VAS were observed.The corneal epithelial healing was studied by fluorescein sodium staining,and BCVA was measured by fluorescein sodium staining.Results:BCVA at 2 months after operation was significantly lower than that before operation(P<0.05).There was no fluorescein staining in the cornea at 10th day after operation,which indicated that the corneal epithelial defect was completely healed.At 1st day after operation,the OSS score and TCHI were higher than those before operation(all P<0.05); with the development of anti-inflammatory treatment,the OSS score and TCHI at 7th day after operation decreased to the preoperative levels(all P>0.05); the above indexes at 1 and 2 months after operation were lower than those before operation(all P<0.05).At 1st day after operation,the VAS score was higher than that before operation(P<0.05); with the development of anti-inflammatory therapy,the VAS score of patients at 7th day after operation decreased to the preoperative level(P>0.05); the VAS score at 2 months after operation was lower than that before operation(P<0.05).Conclusion:OSS,VAS and TCHI can effectively evaluate the inflammatory status of patients undergoing pterygium resection and conjunctival autograft,and can be used as evaluation indicators for the effectiveness of anti-inflammatory treatment.

参考文献/References:

[1] 张明鸿,黄州基.退翳明目汤治疗翼状胬肉切除术后的疗效及对患者泪液功能的影响[J].陕西中医,2018,39(9):1269-1271.
[2] 吴雪梅,杨淑焕,韩志华,等.丝裂霉素C用于翼状胬肉切除结合膜缘干细胞移植术对术后复发率及眼表修复的影响[J].陕西医学杂志,2018,47(12):1541-1543.
[3] Yucekul B,Mocan MC,Kocabeyoglu S,et al.Evaluation of long-term silicone hydrogel use on ocular surface inflammation and tear function in patients with and without meibomian gland dysfunction[J].Eye Contact Lens,2018,45(1):61-66.
[4] 何星光,龚兰兰,余才翰.玻璃酸钠对白内障超声乳化联合IOL植入术后眼部炎症反应和干眼症的影响[J].国际眼科杂志,2018,18(4):697-701.
[5] 黄海香,袁 进,李赛群,等.基于眼表综合分析仪和视觉模拟评分的翼状胬肉术后眼表炎症指数转归[J].中华实验眼科杂志,2018,36(9):693-698.
[6] 彭亚力,熊 成,薛黎萍,等.翼状胬肉切除术后配戴角膜绷带镜对复发的影响[J].中国临床研究,2019,32(7):969-975.
[7] 张 磊.糖尿病视网膜病变患者激光治疗后疼痛反应研究[J].中国中医眼科杂志,2011,21(3):152-154.
[8] 陈佳佳,王文战,王 帅.玻璃体视网膜手术中绷带镜对糖尿病患者角膜的保护作用[J].中华眼外伤职业眼病杂志,2017,39(12):890-895.
[9] 施灵毅.新鲜羊膜球结膜下移植治疗翼状胬肉及对表皮生长因子的影响[J].中国药物与临床,2019,19(8):1337-1339.
[10] Siak JJK,Ng SL,Seet LF,et al.The nuclear-factor κB pathway is activated in pterygium[J].Invest Ophthalmol Vis Sci,2011,52(1):230.
[11] 杨 欣,成拾明,黄锦海,等.应用活体共焦显微镜观察翼状胬肉组织结构[J].中国实用眼科杂志,2011,29(4):368-371.
[12] 张晨晨,李艳霞,郑雅娟.溴芬酸钠滴眼液在眼科中的临床应用[J].国际眼科杂志,2019,19(10):1709-1712.
[13] 汪 波,杨燕宁,黄林英,等.双通道技术联合眼表综合分析仪评价重组人表皮生长因子衍生物滴眼液治疗中度干眼伴浅层点状角膜病变的效果[J].武汉大学学报:医学版,2017,38(4):622-628,663.
[14] Downie LE,Keller PR,Vingrys AJ.Assessing ocular bulbar redness:A comparison of methods[J].Ophthalmic Physiol Opt,2016,36(2):132-139.
[15] Kheirkhah A,Nazari R,Nikdel M,et al.Postoperative conjunctival inflammation after pterygium surgery with amniotic membrane transplantation versus conjunctival autograft[J].Am J Ophthalmol,2011,152(5):733-738.
[16] Kheirkhah A,Nazari R,Safi H,et al.Effects of intraoperative steroid injection on the outcome of pterygium surgery[J].Eye(Lond),2013,27(8):906-914.
[17] 朱利民,何彦津,林婷婷.眼眶急性炎症的病例分析及鉴别诊断[J].眼科新进展,2019,39(7):649-653.
[18] Ghanavati SZ,Shousha MA,Betancurt C,et al.Combined conjunctival autograft and overlay amniotic membrane transplantation; a novel surgical treatment for pterygium[J].J Ophthalmic Vis Res,2014,9(3):399-403.
[19] 梁庆丰,高 超,梁 红,等.活体共聚焦显微镜检查对翼状胬肉活动性评价的应用研究[J].中华眼科杂志,2016,52(10):755-763.
[20] 涂晶晶,费秋香.原发性翼状胬肉与微血管密度的关系研究[J].西南国防医药,2017,27(12):1310-1312.
[21] 陈实玉,姜 洋,余晨颖,等.0.1%溴芬酸钠水合物滴眼液与糖皮质激素在LASEK术后的疗效比较[J].中华眼科杂志,2015,51(1):45-49.

备注/Memo

备注/Memo:
基金项目:陕西省卫生健康委员会科研基金资助项目(2016E007)
更新日期/Last Update: 2021-06-07